E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Synthesis and evaluation of antifungal activity studies of novel 2-(2-pyridyl)-2H-pyrazole-3-carboxamide derivatives

Kunjumon Dayana, Raja Mohamed Kamil, Megaravalli R Manasa, Santhosh M Mathew, Sarah Chatterjee.

Abstract
Background: Invasive fungal infections have negative impact on the health of immunocompromised individuals. With the development of fungal resistance to currently available antifungal drugs, there is a need to develop novel compounds with antifungal activity.

Aims and Objectives: The objectives of the study are as follows: (1) To synthesize novel 2-(2-pyridyl)-2H-pyrazole-3-carboxamide derivatives and (2) to evaluate the antifungal activity of novel 2-(2-pyridyl)-2H-pyrazole-3-carboxamide derivatives.

Materials and Methods: Novel 2-(2-pyridyl)-2H-pyrazole-3-carboxamide derivatives were prepared by multi step synthesis and characterized by LC-MS, 1HNMR and 13C NMR. The antifungal activity of these derivatives was assessed using Fusarium oxysporum, Aspergillus flavus, and Candida albicans by disc diffusion method.

Results: We have synthesized fourteen derivatives of 2-(2-pyridyl)-2H-pyrazole-3-carboxamide. Most of the compounds possess good antifungal activity against F. oxysporum and C. albicans strains.

Conclusion: We synthesized a series of novel 2-(2-pyridyl)-2H-pyrazole-3-carboxamide derivatives having good antifungal activity against F. oxysporus and C. albicans using a simple and low cost procedure.

Key words: Pyrazole; 2-(2-pyridyl)-2H-pyrazole-3-carboxamide; Synthesis; Antifungal activity


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Kunjumon Dayana
Articles by Raja Mohamed Kamil
Articles by Megaravalli R Manasa
Articles by Santhosh M Mathew
Articles by Sarah Chatterjee
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Dayana K, Kamil RM, Manasa MR, Mathew SM, Chatterjee S. Synthesis and evaluation of antifungal activity studies of novel 2-(2-pyridyl)-2H-pyrazole-3-carboxamide derivatives. Natl J Physiol Pharm Pharmacol. 2022; 12(8): 1278-1281. doi:10.5455/njppp.2022.12.07330202206072022


Web Style

Dayana K, Kamil RM, Manasa MR, Mathew SM, Chatterjee S. Synthesis and evaluation of antifungal activity studies of novel 2-(2-pyridyl)-2H-pyrazole-3-carboxamide derivatives. https://www.njppp.com/?mno=75186 [Access: December 01, 2022]. doi:10.5455/njppp.2022.12.07330202206072022


AMA (American Medical Association) Style

Dayana K, Kamil RM, Manasa MR, Mathew SM, Chatterjee S. Synthesis and evaluation of antifungal activity studies of novel 2-(2-pyridyl)-2H-pyrazole-3-carboxamide derivatives. Natl J Physiol Pharm Pharmacol. 2022; 12(8): 1278-1281. doi:10.5455/njppp.2022.12.07330202206072022



Vancouver/ICMJE Style

Dayana K, Kamil RM, Manasa MR, Mathew SM, Chatterjee S. Synthesis and evaluation of antifungal activity studies of novel 2-(2-pyridyl)-2H-pyrazole-3-carboxamide derivatives. Natl J Physiol Pharm Pharmacol. (2022), [cited December 01, 2022]; 12(8): 1278-1281. doi:10.5455/njppp.2022.12.07330202206072022



Harvard Style

Dayana, K., Kamil, . R. M., Manasa, . M. R., Mathew, . S. M. & Chatterjee, . S. (2022) Synthesis and evaluation of antifungal activity studies of novel 2-(2-pyridyl)-2H-pyrazole-3-carboxamide derivatives. Natl J Physiol Pharm Pharmacol, 12 (8), 1278-1281. doi:10.5455/njppp.2022.12.07330202206072022



Turabian Style

Dayana, Kunjumon, Raja Mohamed Kamil, Megaravalli R Manasa, Santhosh M Mathew, and Sarah Chatterjee. 2022. Synthesis and evaluation of antifungal activity studies of novel 2-(2-pyridyl)-2H-pyrazole-3-carboxamide derivatives. National Journal of Physiology, Pharmacy and Pharmacology, 12 (8), 1278-1281. doi:10.5455/njppp.2022.12.07330202206072022



Chicago Style

Dayana, Kunjumon, Raja Mohamed Kamil, Megaravalli R Manasa, Santhosh M Mathew, and Sarah Chatterjee. "Synthesis and evaluation of antifungal activity studies of novel 2-(2-pyridyl)-2H-pyrazole-3-carboxamide derivatives." National Journal of Physiology, Pharmacy and Pharmacology 12 (2022), 1278-1281. doi:10.5455/njppp.2022.12.07330202206072022



MLA (The Modern Language Association) Style

Dayana, Kunjumon, Raja Mohamed Kamil, Megaravalli R Manasa, Santhosh M Mathew, and Sarah Chatterjee. "Synthesis and evaluation of antifungal activity studies of novel 2-(2-pyridyl)-2H-pyrazole-3-carboxamide derivatives." National Journal of Physiology, Pharmacy and Pharmacology 12.8 (2022), 1278-1281. Print. doi:10.5455/njppp.2022.12.07330202206072022



APA (American Psychological Association) Style

Dayana, K., Kamil, . R. M., Manasa, . M. R., Mathew, . S. M. & Chatterjee, . S. (2022) Synthesis and evaluation of antifungal activity studies of novel 2-(2-pyridyl)-2H-pyrazole-3-carboxamide derivatives. National Journal of Physiology, Pharmacy and Pharmacology, 12 (8), 1278-1281. doi:10.5455/njppp.2022.12.07330202206072022