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Original Research 


Synthesis and evaluation of antifungal activity studies of novel 2-(2-pyridyl)-2H-pyrazole-3-carboxamide derivatives

Kunjumon Dayana, Raja Mohamed Kamil, Megaravalli R Manasa, Santhosh M Mathew, Sarah Chatterjee.

Abstract
Background: Invasive fungal infections have negative impact on the health of immunocompromised individuals. With the development of fungal resistance to currently available antifungal drugs, there is a need to develop novel compounds with antifungal activity.

Aims and Objectives: The objectives of the study are as follows: (1) To synthesize novel 2-(2-pyridyl)-2H-pyrazole-3-carboxamide derivatives and (2) to evaluate the antifungal activity of novel 2-(2-pyridyl)-2H-pyrazole-3-carboxamide derivatives.

Materials and Methods: Novel 2-(2-pyridyl)-2H-pyrazole-3-carboxamide derivatives were prepared by multi step synthesis and characterized by LC-MS, 1HNMR and 13C NMR. The antifungal activity of these derivatives was assessed using Fusarium oxysporum, Aspergillus flavus, and Candida albicans by disc diffusion method.

Results: We have synthesized fourteen derivatives of 2-(2-pyridyl)-2H-pyrazole-3-carboxamide. Most of the compounds possess good antifungal activity against F. oxysporum and C. albicans strains.

Conclusion: We synthesized a series of novel 2-(2-pyridyl)-2H-pyrazole-3-carboxamide derivatives having good antifungal activity against F. oxysporus and C. albicans using a simple and low cost procedure.

Key words: Pyrazole; 2-(2-pyridyl)-2H-pyrazole-3-carboxamide; Synthesis; Antifungal activity


 
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How to Cite this Article
Pubmed Style

Dayana K, Kamil RM, Manasa MR, Mathew SM, Chatterjee S. Synthesis and evaluation of antifungal activity studies of novel 2-(2-pyridyl)-2H-pyrazole-3-carboxamide derivatives. Natl J Physiol Pharm Pharmacol. 2022; 12(8): 1278-1281. doi:10.5455/njppp.2022.12.07330202206072022

Web Style

Dayana K, Kamil RM, Manasa MR, Mathew SM, Chatterjee S. Synthesis and evaluation of antifungal activity studies of novel 2-(2-pyridyl)-2H-pyrazole-3-carboxamide derivatives. https://www.njppp.com/?mno=75186 [Access: September 03, 2023]. doi:10.5455/njppp.2022.12.07330202206072022

AMA (American Medical Association) Style

Dayana K, Kamil RM, Manasa MR, Mathew SM, Chatterjee S. Synthesis and evaluation of antifungal activity studies of novel 2-(2-pyridyl)-2H-pyrazole-3-carboxamide derivatives. Natl J Physiol Pharm Pharmacol. 2022; 12(8): 1278-1281. doi:10.5455/njppp.2022.12.07330202206072022


Vancouver/ICMJE Style

Dayana K, Kamil RM, Manasa MR, Mathew SM, Chatterjee S. Synthesis and evaluation of antifungal activity studies of novel 2-(2-pyridyl)-2H-pyrazole-3-carboxamide derivatives. Natl J Physiol Pharm Pharmacol. (2022), [cited September 03, 2023]; 12(8): 1278-1281. doi:10.5455/njppp.2022.12.07330202206072022


Harvard Style

Dayana, K., Kamil, . R. M., Manasa, . M. R., Mathew, . S. M. & Chatterjee, . S. (2022) Synthesis and evaluation of antifungal activity studies of novel 2-(2-pyridyl)-2H-pyrazole-3-carboxamide derivatives. Natl J Physiol Pharm Pharmacol, 12 (8), 1278-1281. doi:10.5455/njppp.2022.12.07330202206072022


Turabian Style

Dayana, Kunjumon, Raja Mohamed Kamil, Megaravalli R Manasa, Santhosh M Mathew, and Sarah Chatterjee. 2022. Synthesis and evaluation of antifungal activity studies of novel 2-(2-pyridyl)-2H-pyrazole-3-carboxamide derivatives. National Journal of Physiology, Pharmacy and Pharmacology, 12 (8), 1278-1281. doi:10.5455/njppp.2022.12.07330202206072022


Chicago Style

Dayana, Kunjumon, Raja Mohamed Kamil, Megaravalli R Manasa, Santhosh M Mathew, and Sarah Chatterjee. "Synthesis and evaluation of antifungal activity studies of novel 2-(2-pyridyl)-2H-pyrazole-3-carboxamide derivatives." National Journal of Physiology, Pharmacy and Pharmacology 12 (2022), 1278-1281. doi:10.5455/njppp.2022.12.07330202206072022


MLA (The Modern Language Association) Style

Dayana, Kunjumon, Raja Mohamed Kamil, Megaravalli R Manasa, Santhosh M Mathew, and Sarah Chatterjee. "Synthesis and evaluation of antifungal activity studies of novel 2-(2-pyridyl)-2H-pyrazole-3-carboxamide derivatives." National Journal of Physiology, Pharmacy and Pharmacology 12.8 (2022), 1278-1281. Print. doi:10.5455/njppp.2022.12.07330202206072022


APA (American Psychological Association) Style

Dayana, K., Kamil, . R. M., Manasa, . M. R., Mathew, . S. M. & Chatterjee, . S. (2022) Synthesis and evaluation of antifungal activity studies of novel 2-(2-pyridyl)-2H-pyrazole-3-carboxamide derivatives. National Journal of Physiology, Pharmacy and Pharmacology, 12 (8), 1278-1281. doi:10.5455/njppp.2022.12.07330202206072022


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