E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research


Effectiveness and safety of carboxymethyl cellulose eye drops in dry eye disease: A real-world study

Aditi Agashe, Janarthanan R., Ajitkumar Gondane, Dattatray Pawar, Akhilesh Sharma.


Abstract
Background:
Dry Eye Disease (DED) is a prevalent multifactorial disorder that affects individuals worldwide and is characterized by insufficient tear production or excessive tear evaporation. Carboxymethylcellulose (CMC) eye drops are widely used for managing DED because of their bio-adhesive properties, which enhance tear retention. However, real-world data on its effectiveness and safety are lacking. Hence

Aim:
To evaluate clinical effectiveness and safety in diverse real-world clinical settings.

Methods:
This multicenter, retrospective, real-world study assessed the medical records of adult patients with DED treated with CMC Eye Drops. The severity of symptoms such as pain, dryness, irritation, poor vision, and sensitivity to light was assessed using a Likert scale at baseline and follow-up visits. Tear break-up time (TBUT) and adverse events were recorded during follow-up. Data was analyzed using descriptive statistics.

Results:
A total of 1853 patients (mean age [±SD]), 43.78 ± 10.66 years; males, 63%) were included in the analysis. The duration of illness noted varied from 0.5 ─ 100 weeks. CMC 0.5% or 1% eye drops were prescribed at a frequency of twice, three times, or four times daily depending on the disease severity. The majority of patients were followed up after 1 month, with an average follow-up duration of 47.30 days. From baseline to follow-up assessment visit, the severity of pain, dryness, irritation, poor vision, and sensitivity to light were reduced by 80%, 68%, 77%, 72%, and 78%, respectively. TBUT was documented at the follow-up visit in 772 patients; of these, 99% patients had a normal TBUT (≥10 seconds) and no patient had an abnormal TBUT (<5 sec). No adverse events were reported during the study period.

Conclusion:
CMC eye drops significantly reduced DED symptoms and showed a favorable safety profile, with no adverse events and normal tear break-up times in most patients.

Key words: Tear Break-Up Time (TBUT), Retrospective study, CMC, DED


 
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How to Cite this Article
Pubmed Style

Agashe A, R. J, Gondane A, Pawar D, Sharma A. Effectiveness and safety of carboxymethyl cellulose eye drops in dry eye disease: A real-world study. Natl J Physiol Pharm Pharmacol. 2025; 15(1): 114-118. doi:10.5455/NJPPP.2025.v15.i1.20


Web Style

Agashe A, R. J, Gondane A, Pawar D, Sharma A. Effectiveness and safety of carboxymethyl cellulose eye drops in dry eye disease: A real-world study. https://www.njppp.com/?mno=227813 [Access: February 12, 2025]. doi:10.5455/NJPPP.2025.v15.i1.20


AMA (American Medical Association) Style

Agashe A, R. J, Gondane A, Pawar D, Sharma A. Effectiveness and safety of carboxymethyl cellulose eye drops in dry eye disease: A real-world study. Natl J Physiol Pharm Pharmacol. 2025; 15(1): 114-118. doi:10.5455/NJPPP.2025.v15.i1.20



Vancouver/ICMJE Style

Agashe A, R. J, Gondane A, Pawar D, Sharma A. Effectiveness and safety of carboxymethyl cellulose eye drops in dry eye disease: A real-world study. Natl J Physiol Pharm Pharmacol. (2025), [cited February 12, 2025]; 15(1): 114-118. doi:10.5455/NJPPP.2025.v15.i1.20



Harvard Style

Agashe, A., R., . J., Gondane, . A., Pawar, . D. & Sharma, . A. (2025) Effectiveness and safety of carboxymethyl cellulose eye drops in dry eye disease: A real-world study. Natl J Physiol Pharm Pharmacol, 15 (1), 114-118. doi:10.5455/NJPPP.2025.v15.i1.20



Turabian Style

Agashe, Aditi, Janarthanan R., Ajitkumar Gondane, Dattatray Pawar, and Akhilesh Sharma. 2025. Effectiveness and safety of carboxymethyl cellulose eye drops in dry eye disease: A real-world study. National Journal of Physiology, Pharmacy and Pharmacology, 15 (1), 114-118. doi:10.5455/NJPPP.2025.v15.i1.20



Chicago Style

Agashe, Aditi, Janarthanan R., Ajitkumar Gondane, Dattatray Pawar, and Akhilesh Sharma. "Effectiveness and safety of carboxymethyl cellulose eye drops in dry eye disease: A real-world study." National Journal of Physiology, Pharmacy and Pharmacology 15 (2025), 114-118. doi:10.5455/NJPPP.2025.v15.i1.20



MLA (The Modern Language Association) Style

Agashe, Aditi, Janarthanan R., Ajitkumar Gondane, Dattatray Pawar, and Akhilesh Sharma. "Effectiveness and safety of carboxymethyl cellulose eye drops in dry eye disease: A real-world study." National Journal of Physiology, Pharmacy and Pharmacology 15.1 (2025), 114-118. Print. doi:10.5455/NJPPP.2025.v15.i1.20



APA (American Psychological Association) Style

Agashe, A., R., . J., Gondane, . A., Pawar, . D. & Sharma, . A. (2025) Effectiveness and safety of carboxymethyl cellulose eye drops in dry eye disease: A real-world study. National Journal of Physiology, Pharmacy and Pharmacology, 15 (1), 114-118. doi:10.5455/NJPPP.2025.v15.i1.20