A comparative study of cardiac autonomic functions in normotensive individuals with and without family history of hypertension

Sandra Christina George; Ahammed Naseem V. H.; Ajay Kumar Saran; Nayana M. Nair

doi:10.5455/NJPPP.2025.v15.i1.3

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Online Published: 05 Jan 2025

Natl J Physiol Pharm Pharmacol. 2025; 15(1): 15-19

doi: 10.5455/NJPPP.2025.v15.i1.3

A comparative study of cardiac autonomic functions in normotensive individuals with and without family history of hypertension

Sandra Christina George, Ahammed Naseem V. H., Ajay Kumar Saran, Nayana M. Nair.

Abstract
Background:
Since genetic heredity accounts for 30% of blood pressure variance, it is seen that the possibility of early-onset hypertension linked to autonomic dysfunction is increased by parental history of hypertension. Hence, in offspring of hypertensive parents, recording blood pressure alone is insufficient and requires an assessment of cardiac autonomic functions.

Aim:
To analyze the cardiovascular autonomic functions of normotensive individuals with a family history of hypertension and compare it with that of age and gender-matched controls.

Methods:
Comparative cross-sectional study conducted in Government Medical College, Kozhikode among 158 subjects (79 normotensives with family history of hypertension and 79 age and sex-matched controls) of age group 18-30 years by simple random sampling. Ewing’s battery of cardiovascular autonomic function tests performed and assessed using 16 channel PHYSIOLAB with PHYSIOPAC software. SPSS 25 software for Windows with Unpaired T-Test was used for statistical analysis.

Results:
Significant increase in sympathetic response was observed in the study group, as compared to controls, presumably due to inherited vascular reactivity. Since autonomic responsiveness to stress serves as a predictor of neurogenic hypertension, the tilt towards sympathetic overactivity may indicate autonomic imbalance preceding the onset of hypertension.

Conclusion:
Increase in sympathetic activity observed in the study group emphasize the effect of genetic influence on hypertension. Early detection, especially in offspring of hypertensive parents, by employing cardiovascular autonomic function tests, helps in implementation of preventive measures that halt the progression of disease

Key words: Cardiovascular autonomic function tests, Family history of hypertension, Ewing’s battery

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Pubmed Style

George SC, H. ANV, Saran AK, Nair NM. A comparative study of cardiac autonomic functions in normotensive individuals with and without family history of hypertension. Natl J Physiol Pharm Pharmacol. 2025; 15(1): 15-19. doi:10.5455/NJPPP.2025.v15.i1.3

Web Style

George SC, H. ANV, Saran AK, Nair NM. A comparative study of cardiac autonomic functions in normotensive individuals with and without family history of hypertension. https://www.njppp.com/?mno=155978 [Access: February 12, 2025]. doi:10.5455/NJPPP.2025.v15.i1.3

AMA (American Medical Association) Style

George SC, H. ANV, Saran AK, Nair NM. A comparative study of cardiac autonomic functions in normotensive individuals with and without family history of hypertension. Natl J Physiol Pharm Pharmacol. 2025; 15(1): 15-19. doi:10.5455/NJPPP.2025.v15.i1.3

Vancouver/ICMJE Style

George SC, H. ANV, Saran AK, Nair NM. A comparative study of cardiac autonomic functions in normotensive individuals with and without family history of hypertension. Natl J Physiol Pharm Pharmacol. (2025), [cited February 12, 2025]; 15(1): 15-19. doi:10.5455/NJPPP.2025.v15.i1.3

Harvard Style

George, S. C., H., . A. N. V., Saran, . A. K. & Nair, . N. M. (2025) A comparative study of cardiac autonomic functions in normotensive individuals with and without family history of hypertension. Natl J Physiol Pharm Pharmacol, 15 (1), 15-19. doi:10.5455/NJPPP.2025.v15.i1.3

Turabian Style

George, Sandra Christina, Ahammed Naseem V. H., Ajay Kumar Saran, and Nayana M. Nair. 2025. A comparative study of cardiac autonomic functions in normotensive individuals with and without family history of hypertension. National Journal of Physiology, Pharmacy and Pharmacology, 15 (1), 15-19. doi:10.5455/NJPPP.2025.v15.i1.3

Chicago Style

George, Sandra Christina, Ahammed Naseem V. H., Ajay Kumar Saran, and Nayana M. Nair. "A comparative study of cardiac autonomic functions in normotensive individuals with and without family history of hypertension." National Journal of Physiology, Pharmacy and Pharmacology 15 (2025), 15-19. doi:10.5455/NJPPP.2025.v15.i1.3

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

George, S. C., H., . A. N. V., Saran, . A. K. & Nair, . N. M. (2025) A comparative study of cardiac autonomic functions in normotensive individuals with and without family history of hypertension. National Journal of Physiology, Pharmacy and Pharmacology, 15 (1), 15-19. doi:10.5455/NJPPP.2025.v15.i1.3

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