E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research


Adverse drug reaction profile of taxanes: A prospective observational study among patients in a tertiary care hospital

Reeza Azeez, Kizhakkan Aboobakker Haseena, Shehna A. Khader, Mangattuvalappil Balakrishnan.


Abstract
Background:
Taxanes are a relatively newer class of anticancer drugs that are being extensively used in the management of various gynecological malignancies, breast cancer, lung cancer and head and neck cancers in India as well as across the world. Despite its widespread use, not many studies have been conducted to evaluate the various adverse drug reactions encountered with Taxanes in actual practice.

Aim:
To study the adverse drug reaction profile of Taxanes and to compare the adverse drug reactions of Paclitaxel and Docetaxel.

Methods:
A prospective observational study of the patients being treated with taxanes for breast, lung, head & neck and gynecological malignancies in the Radiotherapy OPD. Details regarding the ADR was collected via questionnaire filled by direct interview with the patients.

Results:
Neutropenia was the most frequent adverse drug reaction observed with Taxanes (both Paclitaxel and Docetaxel) based therapy accounting for 57% of all ADRs. Glove and stocking peripheral neuropathy was observed the most with Paclitaxel based chemotherapy (70%) while neutropenia was the most frequent ADR associated with Docetaxel based therapy (57%).

Conclusion:
Neutropenia was the most common ADR observed with taxanes altogether and also with Docetaxel based chemotherapy while peripheral neuropathy was the most frequent with Paclitaxel based regimen.

Key words: Cancer, Taxanes, Paclitaxel, Docetaxel, ADRs


 
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How to Cite this Article
Pubmed Style

Azeez R, Haseena KA, Khader SA, Balakrishnan M. Adverse drug reaction profile of taxanes: A prospective observational study among patients in a tertiary care hospital. Natl J Physiol Pharm Pharmacol. 2025; 15(1): 8-14. doi:10.5455/NJPPP.2025.v15.i1.2


Web Style

Azeez R, Haseena KA, Khader SA, Balakrishnan M. Adverse drug reaction profile of taxanes: A prospective observational study among patients in a tertiary care hospital. https://www.njppp.com/?mno=147804 [Access: February 12, 2025]. doi:10.5455/NJPPP.2025.v15.i1.2


AMA (American Medical Association) Style

Azeez R, Haseena KA, Khader SA, Balakrishnan M. Adverse drug reaction profile of taxanes: A prospective observational study among patients in a tertiary care hospital. Natl J Physiol Pharm Pharmacol. 2025; 15(1): 8-14. doi:10.5455/NJPPP.2025.v15.i1.2



Vancouver/ICMJE Style

Azeez R, Haseena KA, Khader SA, Balakrishnan M. Adverse drug reaction profile of taxanes: A prospective observational study among patients in a tertiary care hospital. Natl J Physiol Pharm Pharmacol. (2025), [cited February 12, 2025]; 15(1): 8-14. doi:10.5455/NJPPP.2025.v15.i1.2



Harvard Style

Azeez, R., Haseena, . K. A., Khader, . S. A. & Balakrishnan, . M. (2025) Adverse drug reaction profile of taxanes: A prospective observational study among patients in a tertiary care hospital. Natl J Physiol Pharm Pharmacol, 15 (1), 8-14. doi:10.5455/NJPPP.2025.v15.i1.2



Turabian Style

Azeez, Reeza, Kizhakkan Aboobakker Haseena, Shehna A. Khader, and Mangattuvalappil Balakrishnan. 2025. Adverse drug reaction profile of taxanes: A prospective observational study among patients in a tertiary care hospital. National Journal of Physiology, Pharmacy and Pharmacology, 15 (1), 8-14. doi:10.5455/NJPPP.2025.v15.i1.2



Chicago Style

Azeez, Reeza, Kizhakkan Aboobakker Haseena, Shehna A. Khader, and Mangattuvalappil Balakrishnan. "Adverse drug reaction profile of taxanes: A prospective observational study among patients in a tertiary care hospital." National Journal of Physiology, Pharmacy and Pharmacology 15 (2025), 8-14. doi:10.5455/NJPPP.2025.v15.i1.2



MLA (The Modern Language Association) Style

Azeez, Reeza, Kizhakkan Aboobakker Haseena, Shehna A. Khader, and Mangattuvalappil Balakrishnan. "Adverse drug reaction profile of taxanes: A prospective observational study among patients in a tertiary care hospital." National Journal of Physiology, Pharmacy and Pharmacology 15.1 (2025), 8-14. Print. doi:10.5455/NJPPP.2025.v15.i1.2



APA (American Psychological Association) Style

Azeez, R., Haseena, . K. A., Khader, . S. A. & Balakrishnan, . M. (2025) Adverse drug reaction profile of taxanes: A prospective observational study among patients in a tertiary care hospital. National Journal of Physiology, Pharmacy and Pharmacology, 15 (1), 8-14. doi:10.5455/NJPPP.2025.v15.i1.2