Diagnostic accuracy of c-reactive protein in immunocompromised patients with sepsis in intensive care units

Manu S Menon; Simbita Marwah; Mihir Mehta; Arya D Dipak

doi:10.5455/njppp.2015.5.2011201410

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Original Research
Online Published: 02 Jul 2015

Natl J Physiol Pharm Pharmacol. 2015; 5(3): 166-169

doi: 10.5455/njppp.2015.5.2011201410

Diagnostic accuracy of c-reactive protein in immunocompromised patients with sepsis in intensive care units

Manu S Menon, Simbita Marwah, Mihir Mehta, Arya D Dipak.

Cited By:5

Abstract
Background: It is very crucial to recognize infection in immunocompromised patients. The purpose of this study was to explore the diagnostic accuracy of C-reactive protein (CRP) in critically ill immunocompromised patients with sepsis.

Aims and Objective: To find out the diagnostic utility of CRP in immunocompromised patients with sepsis.

Materials and Methods: This was a cross-sectional study, which included immunocompromised patients with suspected sepsis. Patients were classified into two diagnostic groups: those with nonbacterial sepsis and those with bacterial sepsis, and the values of CRP were estimated.

Results: Of 94 patients (63 men and 31 women) with a median age of 56 years (95% CI 53.959.3), 74 (78.5%) had immunosuppression with nonbacterial sepsis and 20 (21.4%) had immunosuppression with bacterial sepsis. CRP concentrations were higher in the group with bacterial sepsis [30.94 ng/ml (95% CI 25.1336.74)] than those with nonbacterial sepsis [7.46 ng/ml (95% CI 7.057.87), P < 0.0001]. CRP concentrations that were >6 mg/L had 93.33% sensitivity but only 63.20% specificity for diagnosing sepsis. The accuracy of diagnosis was 87.23%. The area under the receiver-operating characteristic curve was 0.82 (0.720.92).

Conclusion: Despite limited specificity in critically ill immunocompromised patients, CRP concentrations may help to rule out bacterial infection.

Key words: C-reactive protein; Immune deficiency; Bacterial sepsis; Non-bacterial sepsis

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How to Cite this Article

Pubmed Style

Menon MS, Marwah S, Mehta M, Dipak AD. Diagnostic accuracy of c-reactive protein in immunocompromised patients with sepsis in intensive care units. Natl J Physiol Pharm Pharmacol. 2015; 5(3): 166-169. doi:10.5455/njppp.2015.5.2011201410

Web Style

Menon MS, Marwah S, Mehta M, Dipak AD. Diagnostic accuracy of c-reactive protein in immunocompromised patients with sepsis in intensive care units. https://www.njppp.com/?mno=173258 [Access: May 05, 2025]. doi:10.5455/njppp.2015.5.2011201410

AMA (American Medical Association) Style

Menon MS, Marwah S, Mehta M, Dipak AD. Diagnostic accuracy of c-reactive protein in immunocompromised patients with sepsis in intensive care units. Natl J Physiol Pharm Pharmacol. 2015; 5(3): 166-169. doi:10.5455/njppp.2015.5.2011201410

Vancouver/ICMJE Style

Menon MS, Marwah S, Mehta M, Dipak AD. Diagnostic accuracy of c-reactive protein in immunocompromised patients with sepsis in intensive care units. Natl J Physiol Pharm Pharmacol. (2015), [cited May 05, 2025]; 5(3): 166-169. doi:10.5455/njppp.2015.5.2011201410

Harvard Style

Menon, M. S., Marwah, . S., Mehta, . M. & Dipak, . A. D. (2015) Diagnostic accuracy of c-reactive protein in immunocompromised patients with sepsis in intensive care units. Natl J Physiol Pharm Pharmacol, 5 (3), 166-169. doi:10.5455/njppp.2015.5.2011201410

Turabian Style

Menon, Manu S, Simbita Marwah, Mihir Mehta, and Arya D Dipak. 2015. Diagnostic accuracy of c-reactive protein in immunocompromised patients with sepsis in intensive care units. National Journal of Physiology, Pharmacy and Pharmacology, 5 (3), 166-169. doi:10.5455/njppp.2015.5.2011201410

Chicago Style

Menon, Manu S, Simbita Marwah, Mihir Mehta, and Arya D Dipak. "Diagnostic accuracy of c-reactive protein in immunocompromised patients with sepsis in intensive care units." National Journal of Physiology, Pharmacy and Pharmacology 5 (2015), 166-169. doi:10.5455/njppp.2015.5.2011201410

MLA (The Modern Language Association) Style

Menon, Manu S, Simbita Marwah, Mihir Mehta, and Arya D Dipak. "Diagnostic accuracy of c-reactive protein in immunocompromised patients with sepsis in intensive care units." National Journal of Physiology, Pharmacy and Pharmacology 5.3 (2015), 166-169. Print. doi:10.5455/njppp.2015.5.2011201410

APA (American Psychological Association) Style

Menon, M. S., Marwah, . S., Mehta, . M. & Dipak, . A. D. (2015) Diagnostic accuracy of c-reactive protein in immunocompromised patients with sepsis in intensive care units. National Journal of Physiology, Pharmacy and Pharmacology, 5 (3), 166-169. doi:10.5455/njppp.2015.5.2011201410

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