Lower esophageal sphincter pressures in gastroesophageal reflux disease: Where do they stand?

Madhu Bhatt; Bikalp Thapa

doi:10.5455/njppp.2015.5.0312201411

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Original Research
Online Published: 02 Jul 2015

Natl J Physiol Pharm Pharmacol. 2015; 5(3): 170-173

doi: 10.5455/njppp.2015.5.0312201411

Lower esophageal sphincter pressures in gastroesophageal reflux disease: Where do they stand?

Madhu Bhatt, Bikalp Thapa.

Cited By:3

Abstract
Background: Esophageal manometry is mandatory for localization of lower esophageal sphincter (LES) in patients undergoing ambulatory esophageal pH-metry for proper positioning of the pH-sensing catheter. Manometry not only gives the location of LES but also provides its tone in terms of basal lower esophageal sphincter pressure (BLESP) in mm Hg.

Aims and Objectives: To study the LES pressures in cases of gastroesophageal reflux disease and to evaluate its significance by determining correlation between LES pressures and DeMeester score.

Materials and Methods: In the study, 54 subjects with clinical diagnosis of gastroesophageal reflux participated. Manometry was performed using pneumohydraulic water perfused system, followed by a 24-h ambulatory esophageal pH-metry. The data were subjected to statistical analysis using SPSS software, version 22.

Results: The mean BLESP was 13.68 ± 3.93 mm Hg, and DeMeester score was 16.94 ± 9.57. A significant negative correlation with a Pearsons correlation coefficient (r) of -0.632 (p < 0.001) was seen between BLESP and DeMeester score.

Conclusion: High DeMeester score as in cases of gastroesophageal reflux is found to be significantly negatively correlated with low values of BLESP.

Key words: Basal Lower Esophageal Sphincter Pressure; Esophageal pH-metry; DeMeester Score; Gastroesophageal Reflux; Correlation

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Pubmed Style

Bhatt M, Thapa B. Lower esophageal sphincter pressures in gastroesophageal reflux disease: Where do they stand?. Natl J Physiol Pharm Pharmacol. 2015; 5(3): 170-173. doi:10.5455/njppp.2015.5.0312201411

Web Style

Bhatt M, Thapa B. Lower esophageal sphincter pressures in gastroesophageal reflux disease: Where do they stand?. https://www.njppp.com/?mno=175918 [Access: November 01, 2025]. doi:10.5455/njppp.2015.5.0312201411

AMA (American Medical Association) Style

Bhatt M, Thapa B. Lower esophageal sphincter pressures in gastroesophageal reflux disease: Where do they stand?. Natl J Physiol Pharm Pharmacol. 2015; 5(3): 170-173. doi:10.5455/njppp.2015.5.0312201411

Vancouver/ICMJE Style

Bhatt M, Thapa B. Lower esophageal sphincter pressures in gastroesophageal reflux disease: Where do they stand?. Natl J Physiol Pharm Pharmacol. (2015), [cited November 01, 2025]; 5(3): 170-173. doi:10.5455/njppp.2015.5.0312201411

Harvard Style

Bhatt, M. & Thapa, . B. (2015) Lower esophageal sphincter pressures in gastroesophageal reflux disease: Where do they stand?. Natl J Physiol Pharm Pharmacol, 5 (3), 170-173. doi:10.5455/njppp.2015.5.0312201411

Turabian Style

Bhatt, Madhu, and Bikalp Thapa. 2015. Lower esophageal sphincter pressures in gastroesophageal reflux disease: Where do they stand?. National Journal of Physiology, Pharmacy and Pharmacology, 5 (3), 170-173. doi:10.5455/njppp.2015.5.0312201411

Chicago Style

Bhatt, Madhu, and Bikalp Thapa. "Lower esophageal sphincter pressures in gastroesophageal reflux disease: Where do they stand?." National Journal of Physiology, Pharmacy and Pharmacology 5 (2015), 170-173. doi:10.5455/njppp.2015.5.0312201411

MLA (The Modern Language Association) Style

Bhatt, Madhu, and Bikalp Thapa. "Lower esophageal sphincter pressures in gastroesophageal reflux disease: Where do they stand?." National Journal of Physiology, Pharmacy and Pharmacology 5.3 (2015), 170-173. Print. doi:10.5455/njppp.2015.5.0312201411

APA (American Psychological Association) Style

Bhatt, M. & Thapa, . B. (2015) Lower esophageal sphincter pressures in gastroesophageal reflux disease: Where do they stand?. National Journal of Physiology, Pharmacy and Pharmacology, 5 (3), 170-173. doi:10.5455/njppp.2015.5.0312201411

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