A glimpse into the pathophysiology, mechanisms, and management of neuropathic pain

Mohammad M Zarshenas; Mahmoodreza Moein; Soliman Mohammadi Samani; Peyman Petramfar

doi:10.5455/njppp.2015.5.2812201418

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Online Published: 02 Jul 2015

Natl J Physiol Pharm Pharmacol. 2015; 5(3): 160-165

doi: 10.5455/njppp.2015.5.2812201418

A glimpse into the pathophysiology, mechanisms, and management of neuropathic pain

Mohammad M Zarshenas, Mahmoodreza Moein, Soliman Mohammadi Samani, Peyman Petramfar.

Abstract
One of the most frequent problems in medical care is the management of patient presenting with chronic pain. Neuropathic pain is related to the injury or disorders affecting peripheral and central nervous systems and is resistant to over-the-counter analgesics and conventional treatment methods. The estimated prevalence for patients presenting classical symptoms of neuropathic pain is eventually reported to be 6%8%. Several mechanisms have been considered and proposed for this disorder. The involvement of small and large sensory fibers as well as motor fibers is a reason for the presence of neuropathic pain. In addition to the lifestyle modification, a number of different therapeutic approaches and treatment protocols have been applied to control the neuropathic pain. However, management is still unsatisfactory. Comorbidities such as depression, anxiety, and sleep disorders are associated with this disorder and should be previously considered and eliminated. Analgesics, tricyclic antidepressants, anticonvulsant, serotonin norepinephrine reuptake inhibitors, and local anesthetic agent as well as opioid analgesics and herbal medicaments such as capsaicin are known treatment lines for the management of neuropathic pain. Regarding the unsuccessfulness of single therapy, poly-pharmacy or combination therapy of two or more agents with synergistic mechanisms and different modes of action seems necessary.

Key words: Neuropathy, Neuropathic Pain, Chronic Pain

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Pubmed Style

Zarshenas MM, Moein M, Samani SM, Petramfar P. A glimpse into the pathophysiology, mechanisms, and management of neuropathic pain. Natl J Physiol Pharm Pharmacol. 2015; 5(3): 160-165. doi:10.5455/njppp.2015.5.2812201418

Web Style

Zarshenas MM, Moein M, Samani SM, Petramfar P. A glimpse into the pathophysiology, mechanisms, and management of neuropathic pain. https://www.njppp.com/?mno=176260 [Access: November 01, 2025]. doi:10.5455/njppp.2015.5.2812201418

AMA (American Medical Association) Style

Zarshenas MM, Moein M, Samani SM, Petramfar P. A glimpse into the pathophysiology, mechanisms, and management of neuropathic pain. Natl J Physiol Pharm Pharmacol. 2015; 5(3): 160-165. doi:10.5455/njppp.2015.5.2812201418

Vancouver/ICMJE Style

Zarshenas MM, Moein M, Samani SM, Petramfar P. A glimpse into the pathophysiology, mechanisms, and management of neuropathic pain. Natl J Physiol Pharm Pharmacol. (2015), [cited November 01, 2025]; 5(3): 160-165. doi:10.5455/njppp.2015.5.2812201418

Harvard Style

Zarshenas, M. M., Moein, . M., Samani, . S. M. & Petramfar, . P. (2015) A glimpse into the pathophysiology, mechanisms, and management of neuropathic pain. Natl J Physiol Pharm Pharmacol, 5 (3), 160-165. doi:10.5455/njppp.2015.5.2812201418

Turabian Style

Zarshenas, Mohammad M, Mahmoodreza Moein, Soliman Mohammadi Samani, and Peyman Petramfar. 2015. A glimpse into the pathophysiology, mechanisms, and management of neuropathic pain. National Journal of Physiology, Pharmacy and Pharmacology, 5 (3), 160-165. doi:10.5455/njppp.2015.5.2812201418

Chicago Style

Zarshenas, Mohammad M, Mahmoodreza Moein, Soliman Mohammadi Samani, and Peyman Petramfar. "A glimpse into the pathophysiology, mechanisms, and management of neuropathic pain." National Journal of Physiology, Pharmacy and Pharmacology 5 (2015), 160-165. doi:10.5455/njppp.2015.5.2812201418

MLA (The Modern Language Association) Style

Zarshenas, Mohammad M, Mahmoodreza Moein, Soliman Mohammadi Samani, and Peyman Petramfar. "A glimpse into the pathophysiology, mechanisms, and management of neuropathic pain." National Journal of Physiology, Pharmacy and Pharmacology 5.3 (2015), 160-165. Print. doi:10.5455/njppp.2015.5.2812201418

APA (American Psychological Association) Style

Zarshenas, M. M., Moein, . M., Samani, . S. M. & Petramfar, . P. (2015) A glimpse into the pathophysiology, mechanisms, and management of neuropathic pain. National Journal of Physiology, Pharmacy and Pharmacology, 5 (3), 160-165. doi:10.5455/njppp.2015.5.2812201418

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