E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Assessment of adverse drug events of atypical antipsychotics in cases with schizophrenia

Tame Kena, Hage Nobin, Jyothinath Kothapalli.

Abstract
Background: Atypical antipsychotics are the drug of choice to manage schizophrenia in general clinical practice. Antipsychotics cause various side effects, including metabolic syndrome, extrapyramidal symptoms, hyperlipidemia, weight gain, and hypotension in patients treated for schizophrenia.

Aims and Objectives: The aim of the study was to assess the side effects due to antipsychotic drugs and their effect on the outcome in schizophrenia cases.

Materials and Methods: A total of 200 cases with the diagnosis of schizophrenia were recruited. Cases were divided into five groups based on administered drugs (Asenapine, Iloperidone, Olanzapine, Aripiprazole, and Ziprasidone). Treatment procedure and side effect profile were documented. Drug side effects were assessed by a standard antipsychotic side-effects evaluation questionnaire. Cases were followed up for the status of side effects at the end of 1st month, 3rd month, 6th month, 9th month, and 12th month.

Results: The rates of weight gain were 20%, 30%, 50%, 25%, and 15% and menstrual complications were seen at 2.5%, 7.5%, 7.5%, 7.5%, and 1% in all five groups, respectively. Lactation disturbance was observed in 5%, 5%, 12.5%, and 5% iloperidone, olanzapine, aripiprazole, and ziprasidone, respectively. The extrapyramidal symptoms were higher in the iloperidone group compared to the asenapine, olanzapine, aripiprazole, and ziprasidone drug groups.

Conclusion: Atypical antipsychotic drug consumption leads to considerable weight gain and few metabolic abnormalities. Clinicians should estimate the adverse events associated with atypical antipsychotics and compare the benefits of antipsychotics versus the quality of life of cases.

Key words: Schizophrenia; Antipsychotic Drugs; Extrapyramidal Symptoms; Metabolic Syndromes


 
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How to Cite this Article
Pubmed Style

Kena T, Nobin H, Kothapalli J. Assessment of adverse drug events of atypical antipsychotics in cases with schizophrenia. Natl J Physiol Pharm Pharmacol. 2023; 13(1): 77-81. doi:10.5455/njppp.2023.13.05249202231052022


Web Style

Kena T, Nobin H, Kothapalli J. Assessment of adverse drug events of atypical antipsychotics in cases with schizophrenia. https://www.njppp.com/?mno=50900 [Access: February 01, 2023]. doi:10.5455/njppp.2023.13.05249202231052022


AMA (American Medical Association) Style

Kena T, Nobin H, Kothapalli J. Assessment of adverse drug events of atypical antipsychotics in cases with schizophrenia. Natl J Physiol Pharm Pharmacol. 2023; 13(1): 77-81. doi:10.5455/njppp.2023.13.05249202231052022



Vancouver/ICMJE Style

Kena T, Nobin H, Kothapalli J. Assessment of adverse drug events of atypical antipsychotics in cases with schizophrenia. Natl J Physiol Pharm Pharmacol. (2023), [cited February 01, 2023]; 13(1): 77-81. doi:10.5455/njppp.2023.13.05249202231052022



Harvard Style

Kena, T., Nobin, . H. & Kothapalli, . J. (2023) Assessment of adverse drug events of atypical antipsychotics in cases with schizophrenia. Natl J Physiol Pharm Pharmacol, 13 (1), 77-81. doi:10.5455/njppp.2023.13.05249202231052022



Turabian Style

Kena, Tame, Hage Nobin, and Jyothinath Kothapalli. 2023. Assessment of adverse drug events of atypical antipsychotics in cases with schizophrenia. National Journal of Physiology, Pharmacy and Pharmacology, 13 (1), 77-81. doi:10.5455/njppp.2023.13.05249202231052022



Chicago Style

Kena, Tame, Hage Nobin, and Jyothinath Kothapalli. "Assessment of adverse drug events of atypical antipsychotics in cases with schizophrenia." National Journal of Physiology, Pharmacy and Pharmacology 13 (2023), 77-81. doi:10.5455/njppp.2023.13.05249202231052022



MLA (The Modern Language Association) Style

Kena, Tame, Hage Nobin, and Jyothinath Kothapalli. "Assessment of adverse drug events of atypical antipsychotics in cases with schizophrenia." National Journal of Physiology, Pharmacy and Pharmacology 13.1 (2023), 77-81. Print. doi:10.5455/njppp.2023.13.05249202231052022



APA (American Psychological Association) Style

Kena, T., Nobin, . H. & Kothapalli, . J. (2023) Assessment of adverse drug events of atypical antipsychotics in cases with schizophrenia. National Journal of Physiology, Pharmacy and Pharmacology, 13 (1), 77-81. doi:10.5455/njppp.2023.13.05249202231052022