E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


The pattern of adverse effects related to antimicrobial therapy in a tertiary care hospital

Reema T, Anuradha M, Ancy George, Sruthi N.

Abstract
Background: Antimicrobial drugs are life-saving drugs but they come with their own share of adverse drug reactions (ADRs). Institutional drug policy helps in the rational use of the antimicrobial for the given clinical condition. This helps in controlling the development of resistance as well as minimizing adverse events.

Aims and Objectives: This study aims to share the pattern of adverse reactions seen to the commonly prescribed antimicrobials.

Materials and Methods: This is a retrospective, observational study. The data of patients, admitted to a tertiary care center in North Kerala who reported adverse effects related to antimicrobial treatment, were obtained from the case files from the medical record library. ADRs with antimicrobials reported during the period from November 2018 to November 2019 were obtained and the data were expressed as percentages in Microsoft excel. Causality assessment was done using the world health organization casualty scale.

Results: 92 case reports were analyzed. Among the different antimicrobials used, Ciprofloxacin was the most commonly prescribed antimicrobial (18.5%) followed by ceftriaxone (12%). 13 different patterns of ADRs were obtained following the use of these drugs, among which allergic reactions to drugs were the most common (71.7%) with a causality assessment showing it to be the probable cause.

Conclusion: The monitoring of ADRs to antimicrobials is the need of the hour. This study helped in determining the different patterns of ADRs with antimicrobials. Active surveillance and complete reporting help in identifying these and reporting and managing them to prevent such occurrences in the future.

Key words: Antimicrobial Drugs; Adverse Drug Reactions; Allergic Reactions


 
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How to Cite this Article
Pubmed Style

T R, M A, George A, N S. The pattern of adverse effects related to antimicrobial therapy in a tertiary care hospital. Natl J Physiol Pharm Pharmacol. 2022; 12(7): 1065-1068. doi:10.5455/njppp.2022.12.05241202203062022


Web Style

T R, M A, George A, N S. The pattern of adverse effects related to antimicrobial therapy in a tertiary care hospital. https://www.njppp.com/?mno=47247 [Access: December 01, 2022]. doi:10.5455/njppp.2022.12.05241202203062022


AMA (American Medical Association) Style

T R, M A, George A, N S. The pattern of adverse effects related to antimicrobial therapy in a tertiary care hospital. Natl J Physiol Pharm Pharmacol. 2022; 12(7): 1065-1068. doi:10.5455/njppp.2022.12.05241202203062022



Vancouver/ICMJE Style

T R, M A, George A, N S. The pattern of adverse effects related to antimicrobial therapy in a tertiary care hospital. Natl J Physiol Pharm Pharmacol. (2022), [cited December 01, 2022]; 12(7): 1065-1068. doi:10.5455/njppp.2022.12.05241202203062022



Harvard Style

T, R., M, . A., George, . A. & N, . S. (2022) The pattern of adverse effects related to antimicrobial therapy in a tertiary care hospital. Natl J Physiol Pharm Pharmacol, 12 (7), 1065-1068. doi:10.5455/njppp.2022.12.05241202203062022



Turabian Style

T, Reema, Anuradha M, Ancy George, and Sruthi N. 2022. The pattern of adverse effects related to antimicrobial therapy in a tertiary care hospital. National Journal of Physiology, Pharmacy and Pharmacology, 12 (7), 1065-1068. doi:10.5455/njppp.2022.12.05241202203062022



Chicago Style

T, Reema, Anuradha M, Ancy George, and Sruthi N. "The pattern of adverse effects related to antimicrobial therapy in a tertiary care hospital." National Journal of Physiology, Pharmacy and Pharmacology 12 (2022), 1065-1068. doi:10.5455/njppp.2022.12.05241202203062022



MLA (The Modern Language Association) Style

T, Reema, Anuradha M, Ancy George, and Sruthi N. "The pattern of adverse effects related to antimicrobial therapy in a tertiary care hospital." National Journal of Physiology, Pharmacy and Pharmacology 12.7 (2022), 1065-1068. Print. doi:10.5455/njppp.2022.12.05241202203062022



APA (American Psychological Association) Style

T, R., M, . A., George, . A. & N, . S. (2022) The pattern of adverse effects related to antimicrobial therapy in a tertiary care hospital. National Journal of Physiology, Pharmacy and Pharmacology, 12 (7), 1065-1068. doi:10.5455/njppp.2022.12.05241202203062022