E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Prescription pattern and rationality of fixed dose combinations in a tertiary care hospital – Record-based cross-sectional study

Lima Koruthara Mohanan, Preetha Jose, Firoz Thaha, Gopesh Valoth.

Abstract
Background: Fixed dose combinations (FDCs) are combinations of two or more active drugs in a single pharmaceutical formulation. The rationality of FDC is a controversial and challenging issue in today’s practice of medicine.

Aims and Objectives: The aim of the study was to assess the prescription pattern and rationality of FDCs in a tertiary care hospital.

Materials and Methods: This is a record-based cross-sectional study conducted in the Department of Pharmacology, Government Medical College, Thrissur. The data were collected from the case records of 183 patients admitted under various departments during the month of January 2019. The FDCs prescribed were listed and the prescription pattern was assessed. All the FDCs were evaluated for rationality with the help of a comprehensive seven-point criteria by Panda et al. The data were analyzed using Epi info 7. Descriptive statistics were used to analyze the data.

Results: Out of 183 case records, 39.3% contained at least one FDC, 13.1% contained two FDCs, and 4.4% contained three FDCs. The different drug classes prescribed as FDCs include anti-infective drugs 45%, vitamins and minerals 33%, analgesics 9%, and miscellaneous drug combinations 13%. The most prescribed anti-infective drug FDC is amoxicillin with clavulanic acid combination (56%). In our study, 92.5% of the antibacterial FDCs prescribed were rational and 7.5% irrational. According to the World Health Organization rationality criteria, 62% of the FDCs prescribed were rational and 38% were irrational.

Conclusion: The present study showed the increased use of FDCs in tertiary care teaching hospital and most of the FDCs prescribed were rational (62%).

Key words: Fixed Dose Combination; Rationality; World Health Organization Essential Medicine List


 
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How to Cite this Article
Pubmed Style

Mohanan LK, Jose P, Thaha F, Valoth G. Prescription pattern and rationality of fixed dose combinations in a tertiary care hospital – Record-based cross-sectional study. Natl J Physiol Pharm Pharmacol. 2022; 12(7): 1058-1064. doi:10.5455/njppp.2022.12.05211202227052022


Web Style

Mohanan LK, Jose P, Thaha F, Valoth G. Prescription pattern and rationality of fixed dose combinations in a tertiary care hospital – Record-based cross-sectional study. https://www.njppp.com/?mno=22348 [Access: December 02, 2022]. doi:10.5455/njppp.2022.12.05211202227052022


AMA (American Medical Association) Style

Mohanan LK, Jose P, Thaha F, Valoth G. Prescription pattern and rationality of fixed dose combinations in a tertiary care hospital – Record-based cross-sectional study. Natl J Physiol Pharm Pharmacol. 2022; 12(7): 1058-1064. doi:10.5455/njppp.2022.12.05211202227052022



Vancouver/ICMJE Style

Mohanan LK, Jose P, Thaha F, Valoth G. Prescription pattern and rationality of fixed dose combinations in a tertiary care hospital – Record-based cross-sectional study. Natl J Physiol Pharm Pharmacol. (2022), [cited December 02, 2022]; 12(7): 1058-1064. doi:10.5455/njppp.2022.12.05211202227052022



Harvard Style

Mohanan, L. K., Jose, . P., Thaha, . F. & Valoth, . G. (2022) Prescription pattern and rationality of fixed dose combinations in a tertiary care hospital – Record-based cross-sectional study. Natl J Physiol Pharm Pharmacol, 12 (7), 1058-1064. doi:10.5455/njppp.2022.12.05211202227052022



Turabian Style

Mohanan, Lima Koruthara, Preetha Jose, Firoz Thaha, and Gopesh Valoth. 2022. Prescription pattern and rationality of fixed dose combinations in a tertiary care hospital – Record-based cross-sectional study. National Journal of Physiology, Pharmacy and Pharmacology, 12 (7), 1058-1064. doi:10.5455/njppp.2022.12.05211202227052022



Chicago Style

Mohanan, Lima Koruthara, Preetha Jose, Firoz Thaha, and Gopesh Valoth. "Prescription pattern and rationality of fixed dose combinations in a tertiary care hospital – Record-based cross-sectional study." National Journal of Physiology, Pharmacy and Pharmacology 12 (2022), 1058-1064. doi:10.5455/njppp.2022.12.05211202227052022



MLA (The Modern Language Association) Style

Mohanan, Lima Koruthara, Preetha Jose, Firoz Thaha, and Gopesh Valoth. "Prescription pattern and rationality of fixed dose combinations in a tertiary care hospital – Record-based cross-sectional study." National Journal of Physiology, Pharmacy and Pharmacology 12.7 (2022), 1058-1064. Print. doi:10.5455/njppp.2022.12.05211202227052022



APA (American Psychological Association) Style

Mohanan, L. K., Jose, . P., Thaha, . F. & Valoth, . G. (2022) Prescription pattern and rationality of fixed dose combinations in a tertiary care hospital – Record-based cross-sectional study. National Journal of Physiology, Pharmacy and Pharmacology, 12 (7), 1058-1064. doi:10.5455/njppp.2022.12.05211202227052022