E-ISSN 2231-3206 | ISSN 2320-4672
 

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Drug utilization study in patients affected with COVID-19 in a dedicated COVID hospital

Ashwin Balasubramanian, Prakash Narayan Khandelwal, Harshit Tushar Zaveri, Miti Gandhi, Ipseeta Ray, Dattatray Bhusare.

Abstract
Background: There exists a treatment dilemma regarding the optimal and effective use of therapeutic drugs (hydroxychloroquine/chloroquine/azithromycin) for COVID-19. Furthermore, with changing guidelines, the data on drug utilization patterns across India are limited. Hence, this study was conducted to assess the prescription pattern and drug utilization trends in COVID-19 patients with the aim to study the drug utilization pattern in patients affected with COVID-19 in a dedicated COVID-19 hospital.

Aims and Objectives: The objectives of the study are as follows: (1) To study drug utilization patterns according to the severity of the disease. (2) To study the prevalence of adverse drug reactions (ADRs).

Materials and Methods: Data were collected retrospectively from 100 medical records of patients ≥18 years irrespective of sex admitted in the COVID ward and ICU of a dedicated COVID hospital from May to August 2020. Pregnant and lactating women were excluded from the study. ADRs reported were also analyzed.

Results: About 71% were mild in this study, 18% were moderate, and 11% were severe COVID-19 patients. Overall, the most common drugs prescribed were multivitamins, followed by pantoprazole, paracetamol, and azithromycin. Hydroxychloroquine was prescribed in 22%, favipiravir in 7%, and remdesivir in 3% of cases. The majority of moderate COVID patients received injectables piperacillin-tazobactam, methylprednisolone, and enoxaparin. The mean number of medications, duration of admission, and number of days on oxygen were higher and significant in moderate compared to mild and severe COVID patients. Overall, ADRs were encountered in 9% of cases.

Conclusion: The prescribed pattern of drugs was by the national standard guidelines. Multivitamins, followed by pantoprazole, paracetamol, and azithromycin dominated the prescription pattern. Polypharmacy was encountered, which needs to be addressed for the rational use of drugs.

Key words: COVID-19; SARS-CoV2; Coronavirus; Drug utilization


 
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How to Cite this Article
Pubmed Style

Balasubramanian A, Khandelwal PN, Zaveri HT, Gandhi M, Ray I, Bhusare D. Drug utilization study in patients affected with COVID-19 in a dedicated COVID hospital. Natl J Physiol Pharm Pharmacol. 2023; 13(1): 58-62. doi:10.5455/njppp.2023.13.05243202226052022


Web Style

Balasubramanian A, Khandelwal PN, Zaveri HT, Gandhi M, Ray I, Bhusare D. Drug utilization study in patients affected with COVID-19 in a dedicated COVID hospital. https://www.njppp.com/?mno=45248 [Access: February 01, 2023]. doi:10.5455/njppp.2023.13.05243202226052022


AMA (American Medical Association) Style

Balasubramanian A, Khandelwal PN, Zaveri HT, Gandhi M, Ray I, Bhusare D. Drug utilization study in patients affected with COVID-19 in a dedicated COVID hospital. Natl J Physiol Pharm Pharmacol. 2023; 13(1): 58-62. doi:10.5455/njppp.2023.13.05243202226052022



Vancouver/ICMJE Style

Balasubramanian A, Khandelwal PN, Zaveri HT, Gandhi M, Ray I, Bhusare D. Drug utilization study in patients affected with COVID-19 in a dedicated COVID hospital. Natl J Physiol Pharm Pharmacol. (2023), [cited February 01, 2023]; 13(1): 58-62. doi:10.5455/njppp.2023.13.05243202226052022



Harvard Style

Balasubramanian, A., Khandelwal, . P. N., Zaveri, . H. T., Gandhi, . M., Ray, . I. & Bhusare, . D. (2023) Drug utilization study in patients affected with COVID-19 in a dedicated COVID hospital. Natl J Physiol Pharm Pharmacol, 13 (1), 58-62. doi:10.5455/njppp.2023.13.05243202226052022



Turabian Style

Balasubramanian, Ashwin, Prakash Narayan Khandelwal, Harshit Tushar Zaveri, Miti Gandhi, Ipseeta Ray, and Dattatray Bhusare. 2023. Drug utilization study in patients affected with COVID-19 in a dedicated COVID hospital. National Journal of Physiology, Pharmacy and Pharmacology, 13 (1), 58-62. doi:10.5455/njppp.2023.13.05243202226052022



Chicago Style

Balasubramanian, Ashwin, Prakash Narayan Khandelwal, Harshit Tushar Zaveri, Miti Gandhi, Ipseeta Ray, and Dattatray Bhusare. "Drug utilization study in patients affected with COVID-19 in a dedicated COVID hospital." National Journal of Physiology, Pharmacy and Pharmacology 13 (2023), 58-62. doi:10.5455/njppp.2023.13.05243202226052022



MLA (The Modern Language Association) Style

Balasubramanian, Ashwin, Prakash Narayan Khandelwal, Harshit Tushar Zaveri, Miti Gandhi, Ipseeta Ray, and Dattatray Bhusare. "Drug utilization study in patients affected with COVID-19 in a dedicated COVID hospital." National Journal of Physiology, Pharmacy and Pharmacology 13.1 (2023), 58-62. Print. doi:10.5455/njppp.2023.13.05243202226052022



APA (American Psychological Association) Style

Balasubramanian, A., Khandelwal, . P. N., Zaveri, . H. T., Gandhi, . M., Ray, . I. & Bhusare, . D. (2023) Drug utilization study in patients affected with COVID-19 in a dedicated COVID hospital. National Journal of Physiology, Pharmacy and Pharmacology, 13 (1), 58-62. doi:10.5455/njppp.2023.13.05243202226052022