E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


A study to monitor adverse drug reactions in patients of chronic obstructive pulmonary disease, asthma and bronchiectasis

Pawan Maurya, Florance Joy, J L Marko.

Abstract
Background: These Diseases are chronic and often have complex pathologies which lead to polypharmacy and causes unwanted adverse drug reaction (ADRs). We conducted this study at Respiratory Medicine Department of Gandhi Medical College and associated Hamidia Hospitals, Bhopal.

Aim and Objective: The objectives of the study were (i) to monitor and assess ADRs in patients of chronic obstructive pulmonary disease (COPD), Asthma, Bronchiectasis; and (ii) to assess causality of the ADR using WHO-UMC causality assessment system and Naranjo’s ADR probability scale.

Materials and Methods: The present study indicates the pattern and spectrum of ADRs due to drugs used in the treatment of COPD, Asthma, Bronchiectasis. 159 patients from Respiratory Medicine, Gandhi Medical College receiving chemotherapy were enrolled in study after written informed consent of patients. Approval was obtained from institutional ethics committee. It was cross-sectional, observational study. Prescriptions were analyzed for number of drugs prescribed using a predesigned format. Any ADR observed by patient or treating physician was noted and causality was assessed by Naranjo’s algorithm and WHO-UMC scale.

Results: In our study, most important causative drug was Budesonide (12.3%). Causality assessment of ADR by Naranjo’s algorithm showed 22% probable and 78% possible reactions. According to WHO-UMC scale, 81% reactions are possible, 17% are probable, and 2% are unlikely.

Conclusion: To minimize this high incidence of ADRs dose individualization and therapeutic monitoring of medicine is important. In clinical practice, special precautions while prescribing these drugs with well-known potential for causing ADRs, early detection and appropriate intervention are required. This may greatly contribute to reduce the incidence, frequency, severity, morbidity, and possible mortality.

Key words: Obstructive Pulmonary Diseases; Adverse Drug Reaction; Polypharmacy; Budesonide; Prescription Pattern


 
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How to Cite this Article
Pubmed Style

Maurya P, Joy F, Marko JL. A study to monitor adverse drug reactions in patients of chronic obstructive pulmonary disease, asthma and bronchiectasis. Natl J Physiol Pharm Pharmacol. 2022; 12(7): 997-1002. doi:10.5455/njppp.2022.12.05201202217052022


Web Style

Maurya P, Joy F, Marko JL. A study to monitor adverse drug reactions in patients of chronic obstructive pulmonary disease, asthma and bronchiectasis. https://www.njppp.com/?mno=34191 [Access: March 05, 2023]. doi:10.5455/njppp.2022.12.05201202217052022


AMA (American Medical Association) Style

Maurya P, Joy F, Marko JL. A study to monitor adverse drug reactions in patients of chronic obstructive pulmonary disease, asthma and bronchiectasis. Natl J Physiol Pharm Pharmacol. 2022; 12(7): 997-1002. doi:10.5455/njppp.2022.12.05201202217052022



Vancouver/ICMJE Style

Maurya P, Joy F, Marko JL. A study to monitor adverse drug reactions in patients of chronic obstructive pulmonary disease, asthma and bronchiectasis. Natl J Physiol Pharm Pharmacol. (2022), [cited March 05, 2023]; 12(7): 997-1002. doi:10.5455/njppp.2022.12.05201202217052022



Harvard Style

Maurya, P., Joy, . F. & Marko, . J. L. (2022) A study to monitor adverse drug reactions in patients of chronic obstructive pulmonary disease, asthma and bronchiectasis. Natl J Physiol Pharm Pharmacol, 12 (7), 997-1002. doi:10.5455/njppp.2022.12.05201202217052022



Turabian Style

Maurya, Pawan, Florance Joy, and J L Marko. 2022. A study to monitor adverse drug reactions in patients of chronic obstructive pulmonary disease, asthma and bronchiectasis. National Journal of Physiology, Pharmacy and Pharmacology, 12 (7), 997-1002. doi:10.5455/njppp.2022.12.05201202217052022



Chicago Style

Maurya, Pawan, Florance Joy, and J L Marko. "A study to monitor adverse drug reactions in patients of chronic obstructive pulmonary disease, asthma and bronchiectasis." National Journal of Physiology, Pharmacy and Pharmacology 12 (2022), 997-1002. doi:10.5455/njppp.2022.12.05201202217052022



MLA (The Modern Language Association) Style

Maurya, Pawan, Florance Joy, and J L Marko. "A study to monitor adverse drug reactions in patients of chronic obstructive pulmonary disease, asthma and bronchiectasis." National Journal of Physiology, Pharmacy and Pharmacology 12.7 (2022), 997-1002. Print. doi:10.5455/njppp.2022.12.05201202217052022



APA (American Psychological Association) Style

Maurya, P., Joy, . F. & Marko, . J. L. (2022) A study to monitor adverse drug reactions in patients of chronic obstructive pulmonary disease, asthma and bronchiectasis. National Journal of Physiology, Pharmacy and Pharmacology, 12 (7), 997-1002. doi:10.5455/njppp.2022.12.05201202217052022