E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Comparative study of anti-nociceptive effect of venlafaxine with tramadol by tail-flick test in animal model of mice

Sandeep Bandapati, Karuna Sree Podila, Venkata Rao Yadala.

Abstract
Background: Pain management is ever challenging task to the treating physicians. Always there is search for new medication for pain management. In this context, use of antidepressants in pain management had shown promising results. Venlafaxine is a newer antidepressant drug belonging to selective norepinephrine reuptake inhibitor class, this study was planned to evaluate the venlafaxine antinociceptive effect.

Aims and Objectives: This study aims to evaluate the venlafaxine antinociceptive activity and to compare the venlafaxine antinociceptive effect with tramadol by tail-flick test in an animal model in albino mice.

Materials and Methods: Albino mice of either sex were randomly selected with reaction time of <6 s by tail-flick method using analgesiometer which were included in the study. Number of groups were seven, with 6 mice in each, based on the drug received, that is, venlafaxine 15 mg/kg, 30 mg/kg, 60 mg/kg, 10 mg/kg, and 20 mg/kg of tramadol, control group (distilled water), and combination group venlafaxine (15 mg/kg) + tramadol (10 mg/kg). Tail withdrawal latency period was calculated for each animal in group at 0, 15, 30, 60, and 90 min after administration of drug. Results were analyzed.

Results: At doses of 30 mg/kg and 60 mg/kg of venlafaxine, 20 mg/kg of tramadol, and combination group, had shown significant (P < 0.001) increase in tail-flick latency when compared to control group (normal saline). Venlafaxine 60 mg/kg but less potent (P = 0.86) to tramadol 20 mg/kg.

Conclusion: Venlafaxine was having anti-nociceptive effect at doses of 30 mg/kg and 60 mg/kg and was less potent than tramadol.

Key words: Venlafaxine; Tail-Flick Test; Analgesic; Chronic Pain


 
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How to Cite this Article
Pubmed Style

Bandapati S, Podila KS, Yadala VR. Comparative study of anti-nociceptive effect of venlafaxine with tramadol by tail-flick test in animal model of mice. Natl J Physiol Pharm Pharmacol. 2021; 11(6): 633-637. doi:10.5455/njppp.2021.11.11307202001022021


Web Style

Bandapati S, Podila KS, Yadala VR. Comparative study of anti-nociceptive effect of venlafaxine with tramadol by tail-flick test in animal model of mice. http://www.njppp.com/?mno=27495 [Access: June 01, 2021]. doi:10.5455/njppp.2021.11.11307202001022021


AMA (American Medical Association) Style

Bandapati S, Podila KS, Yadala VR. Comparative study of anti-nociceptive effect of venlafaxine with tramadol by tail-flick test in animal model of mice. Natl J Physiol Pharm Pharmacol. 2021; 11(6): 633-637. doi:10.5455/njppp.2021.11.11307202001022021



Vancouver/ICMJE Style

Bandapati S, Podila KS, Yadala VR. Comparative study of anti-nociceptive effect of venlafaxine with tramadol by tail-flick test in animal model of mice. Natl J Physiol Pharm Pharmacol. (2021), [cited June 01, 2021]; 11(6): 633-637. doi:10.5455/njppp.2021.11.11307202001022021



Harvard Style

Bandapati, S., Podila, . K. S. & Yadala, . V. R. (2021) Comparative study of anti-nociceptive effect of venlafaxine with tramadol by tail-flick test in animal model of mice. Natl J Physiol Pharm Pharmacol, 11 (6), 633-637. doi:10.5455/njppp.2021.11.11307202001022021



Turabian Style

Bandapati, Sandeep, Karuna Sree Podila, and Venkata Rao Yadala. 2021. Comparative study of anti-nociceptive effect of venlafaxine with tramadol by tail-flick test in animal model of mice. National Journal of Physiology, Pharmacy and Pharmacology, 11 (6), 633-637. doi:10.5455/njppp.2021.11.11307202001022021



Chicago Style

Bandapati, Sandeep, Karuna Sree Podila, and Venkata Rao Yadala. "Comparative study of anti-nociceptive effect of venlafaxine with tramadol by tail-flick test in animal model of mice." National Journal of Physiology, Pharmacy and Pharmacology 11 (2021), 633-637. doi:10.5455/njppp.2021.11.11307202001022021



MLA (The Modern Language Association) Style

Bandapati, Sandeep, Karuna Sree Podila, and Venkata Rao Yadala. "Comparative study of anti-nociceptive effect of venlafaxine with tramadol by tail-flick test in animal model of mice." National Journal of Physiology, Pharmacy and Pharmacology 11.6 (2021), 633-637. Print. doi:10.5455/njppp.2021.11.11307202001022021



APA (American Psychological Association) Style

Bandapati, S., Podila, . K. S. & Yadala, . V. R. (2021) Comparative study of anti-nociceptive effect of venlafaxine with tramadol by tail-flick test in animal model of mice. National Journal of Physiology, Pharmacy and Pharmacology, 11 (6), 633-637. doi:10.5455/njppp.2021.11.11307202001022021