Comparative analysis of sympathetic nervous system activity in pre‑menopausal and post-menopausal women

Sheveta Dureja; Vikram Bhandari; Kailash Chander Manchanda; Ram Sarup Sharma; Mridu Gupta; Rachna Bachhel

doi:10.5455/njppp.2017.7.0514611052017

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Online Published: 19 May 2017

Natl J Physiol Pharm Pharmacol. 2017; 7(9): 968-971

doi: 10.5455/njppp.2017.7.0514611052017

Comparative analysis of sympathetic nervous system activity in pre‑menopausal and post-menopausal women

Sheveta Dureja, Vikram Bhandari, Kailash Chander Manchanda, Ram Sarup Sharma, Mridu Gupta, Rachna Bachhel.

Cited By:3

Abstract
Background: Post-menopausal women suffer from various complications like autonomic dysfunction which predisposes them to cardiovascular morbidity. Decline in estrogen levels after menopause is associated with increased cardiovascular risks. Timely evaluation of such derangements and active intervention can play an important role in the prevention of cardiovascular morbidity.

Aims and Objective: The aim is to compare the sympathetic autonomic nervous system activity in pre-menopausal and age-matched post-menopausal women.

Materials and Methods: This study was conducted on two groups of 40 women each. Group I included pre-menopausal women and Group II included post-menopausal women. Sympathetic nervous system assessment was done using cold pressor test (CPT), handgrip test (HGT), and blood pressure (BP) response to standing. Statistical analysis was performed using Students t-test.

Results: Evaluation of sympathetic functions between the two groups showed that the mean rise in systolic BP (SBP) in response to CPT was lower in Group I than in Group II (P < 0.01). Mean rise in the diastolic BP (DBP) in response to HGT was also lower in Group I as compared to Group II (P < 0.01). Fall in SBP on standing in Group I was more than in Group II (P < 0.01).

Conclusion: Sympathetic nervous system evaluation showed sympathetic hyperactivity in the post-menopausal group as compared to the premenopausal group.

Key words: Menopause; Sympathetic; Cardiovascular; Estrogen

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Pubmed Style

Dureja S, Bhandari V, Manchanda KC, Sharma RS, Gupta M, Bachhel R. Comparative analysis of sympathetic nervous system activity in pre‑menopausal and post-menopausal women. Natl J Physiol Pharm Pharmacol. 2017; 7(9): 968-971. doi:10.5455/njppp.2017.7.0514611052017

Web Style

Dureja S, Bhandari V, Manchanda KC, Sharma RS, Gupta M, Bachhel R. Comparative analysis of sympathetic nervous system activity in pre‑menopausal and post-menopausal women. https://www.njppp.com/?mno=265610 [Access: November 01, 2025]. doi:10.5455/njppp.2017.7.0514611052017

AMA (American Medical Association) Style

Dureja S, Bhandari V, Manchanda KC, Sharma RS, Gupta M, Bachhel R. Comparative analysis of sympathetic nervous system activity in pre‑menopausal and post-menopausal women. Natl J Physiol Pharm Pharmacol. 2017; 7(9): 968-971. doi:10.5455/njppp.2017.7.0514611052017

Vancouver/ICMJE Style

Dureja S, Bhandari V, Manchanda KC, Sharma RS, Gupta M, Bachhel R. Comparative analysis of sympathetic nervous system activity in pre‑menopausal and post-menopausal women. Natl J Physiol Pharm Pharmacol. (2017), [cited November 01, 2025]; 7(9): 968-971. doi:10.5455/njppp.2017.7.0514611052017

Harvard Style

Dureja, S., Bhandari, . V., Manchanda, . K. C., Sharma, . R. S., Gupta, . M. & Bachhel, . R. (2017) Comparative analysis of sympathetic nervous system activity in pre‑menopausal and post-menopausal women. Natl J Physiol Pharm Pharmacol, 7 (9), 968-971. doi:10.5455/njppp.2017.7.0514611052017

Turabian Style

Dureja, Sheveta, Vikram Bhandari, Kailash Chander Manchanda, Ram Sarup Sharma, Mridu Gupta, and Rachna Bachhel. 2017. Comparative analysis of sympathetic nervous system activity in pre‑menopausal and post-menopausal women. National Journal of Physiology, Pharmacy and Pharmacology, 7 (9), 968-971. doi:10.5455/njppp.2017.7.0514611052017

Chicago Style

Dureja, Sheveta, Vikram Bhandari, Kailash Chander Manchanda, Ram Sarup Sharma, Mridu Gupta, and Rachna Bachhel. "Comparative analysis of sympathetic nervous system activity in pre‑menopausal and post-menopausal women." National Journal of Physiology, Pharmacy and Pharmacology 7 (2017), 968-971. doi:10.5455/njppp.2017.7.0514611052017

MLA (The Modern Language Association) Style

Dureja, Sheveta, Vikram Bhandari, Kailash Chander Manchanda, Ram Sarup Sharma, Mridu Gupta, and Rachna Bachhel. "Comparative analysis of sympathetic nervous system activity in pre‑menopausal and post-menopausal women." National Journal of Physiology, Pharmacy and Pharmacology 7.9 (2017), 968-971. Print. doi:10.5455/njppp.2017.7.0514611052017

APA (American Psychological Association) Style

Dureja, S., Bhandari, . V., Manchanda, . K. C., Sharma, . R. S., Gupta, . M. & Bachhel, . R. (2017) Comparative analysis of sympathetic nervous system activity in pre‑menopausal and post-menopausal women. National Journal of Physiology, Pharmacy and Pharmacology, 7 (9), 968-971. doi:10.5455/njppp.2017.7.0514611052017

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