Polydipsia: Comparative action of two antipsychotics  Pimozide and ziprasidone

Rakesh Ranjan Pathak; Seema Rawat; Shambhu Sharan Prasad

doi:10.5455/njppp.2017.7.0102202022017

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Original Research
Online Published: 15 Feb 2017

Natl J Physiol Pharm Pharmacol. 2017; 7(6): 582-590

doi: 10.5455/njppp.2017.7.0102202022017

Polydipsia: Comparative action of two antipsychotics Pimozide and ziprasidone

Rakesh Ranjan Pathak, Seema Rawat, Shambhu Sharan Prasad.

Abstract
Background: Primary polydipsia occurs without any central (vasopressin) deficit and/or peripheral (nephrogenic) organic impairment-associated with schizophrenia/obsessive compulsive disorder. In absence of associated symptoms/signs, it is idiopathic (might be preclinical/prodromic). Antipsychotics are tried with some claim but none is satisfactory.

Aims and Objective: Unlike ziprasidone, pimozide misses D1/muscarinic/adrenergic/histaminic actions - the experiment assessed its physiological manifestation and clinical potentials against polydipsia.

Materials and Methods: Three batches of 21 Wistar male albino rats into two successive phases (viz. Normal and, after a washout period for 30 days, schedule-induced polydipsia) were divided into 3 groups (minimal, half maximal, and maximal dose). These 3 groups were divided into 3 subgroups of control, drug 1 and drug 2-each of 7 rats. Rat doses were analogous to permitted human doses.

Result: Daily water intake lowering effect was evident only in polydipsic rats. Half-maximal dose of ziprasidone equated to maximal dose of pimozide.

Conclusion: Ziprasidone (half maximal dose) can avoid the adverse drug reactions (ADRs) of pimozide (maximal dose) in humans polydipsia - though ADR manifestations may be wide-spread (more receptors involved).

Key words: Polydipsia; Schizophrenia; Pimozide; Risperidone; Body Weight

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Pubmed Style

Pathak RR, Rawat S, Prasad SS. Polydipsia: Comparative action of two antipsychotics Pimozide and ziprasidone. Natl J Physiol Pharm Pharmacol. 2017; 7(6): 582-590. doi:10.5455/njppp.2017.7.0102202022017

Web Style

Pathak RR, Rawat S, Prasad SS. Polydipsia: Comparative action of two antipsychotics Pimozide and ziprasidone. https://www.njppp.com/?mno=257323 [Access: November 01, 2025]. doi:10.5455/njppp.2017.7.0102202022017

AMA (American Medical Association) Style

Pathak RR, Rawat S, Prasad SS. Polydipsia: Comparative action of two antipsychotics Pimozide and ziprasidone. Natl J Physiol Pharm Pharmacol. 2017; 7(6): 582-590. doi:10.5455/njppp.2017.7.0102202022017

Vancouver/ICMJE Style

Pathak RR, Rawat S, Prasad SS. Polydipsia: Comparative action of two antipsychotics Pimozide and ziprasidone. Natl J Physiol Pharm Pharmacol. (2017), [cited November 01, 2025]; 7(6): 582-590. doi:10.5455/njppp.2017.7.0102202022017

Harvard Style

Pathak, R. R., Rawat, . S. & Prasad, . S. S. (2017) Polydipsia: Comparative action of two antipsychotics Pimozide and ziprasidone. Natl J Physiol Pharm Pharmacol, 7 (6), 582-590. doi:10.5455/njppp.2017.7.0102202022017

Turabian Style

Pathak, Rakesh Ranjan, Seema Rawat, and Shambhu Sharan Prasad. 2017. Polydipsia: Comparative action of two antipsychotics Pimozide and ziprasidone. National Journal of Physiology, Pharmacy and Pharmacology, 7 (6), 582-590. doi:10.5455/njppp.2017.7.0102202022017

Chicago Style

Pathak, Rakesh Ranjan, Seema Rawat, and Shambhu Sharan Prasad. "Polydipsia: Comparative action of two antipsychotics Pimozide and ziprasidone." National Journal of Physiology, Pharmacy and Pharmacology 7 (2017), 582-590. doi:10.5455/njppp.2017.7.0102202022017

MLA (The Modern Language Association) Style

Pathak, Rakesh Ranjan, Seema Rawat, and Shambhu Sharan Prasad. "Polydipsia: Comparative action of two antipsychotics Pimozide and ziprasidone." National Journal of Physiology, Pharmacy and Pharmacology 7.6 (2017), 582-590. Print. doi:10.5455/njppp.2017.7.0102202022017

APA (American Psychological Association) Style

Pathak, R. R., Rawat, . S. & Prasad, . S. S. (2017) Polydipsia: Comparative action of two antipsychotics Pimozide and ziprasidone. National Journal of Physiology, Pharmacy and Pharmacology, 7 (6), 582-590. doi:10.5455/njppp.2017.7.0102202022017

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