Establishment of an age-specific reference range for serum total prostate-specific antigen levels among the Indian Bengali male population in a tertiary care hospital

Abhisek Das Choudhury; Pradipta Ghosh; Papia Sen; Amrita Mukherjee

doi:10.5455/NJPPP.2025.v15.i2.8

2025, Vol: 15, Issue: 2

15 / 2Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Required files to be uploaded

NJPPP Manuscript Submission Form

« Previous Article

Original Research

Natl J Physiol Pharm Pharmacol. 2025; 15(2): 162-166

doi: 10.5455/NJPPP.2025.v15.i2.8

Establishment of an age-specific reference range for serum total prostate-specific antigen levels among the Indian Bengali male population in a tertiary care hospital

Abhisek Das Choudhury, Pradipta Ghosh, Papia Sen, Amrita Mukherjee.

Abstract
Background:
Globally, prostate cancer is the most prevalent malignant tumor associated with mortality in men. The most widely used tumor marker for prostate cancer diagnosis is the prostate-specific antigen (PSA). It is already known that racial and geographic factors influence blood PSA levels in various parts of the world. The main flaw of the currently utilized threshold of 4.0 ng/ml is that it underestimates the risk of cancer in younger men and causes unnecessary biopsies in older men. To the best of our knowledge, no reports have offered an age-specific reference range for serum total PSA levels in the male Bengali population of India.

Aim:
Establishment of an age-specific reference range for serum total PSA levels among the Indian Bengali male population in a Tertiary Care Hospital.

Methods: A cross-sectional study was undertaken by R. G. Kar Medical College, including 822 healthy Indian Bengali males aged 30 years and above. The study population was divided into four age groups. After recording the general and clinical findings, serum total PSA was estimated using chemiluminescence immunoassay.

Results:
In the age group (30–39) years the reference range is 0.02–1.9 ng/ml. In the 40–49 years age group and in the 50–59 years age group the reference ranges are 0.03–2.1 ng/ml and 0.03–2.8 ng/ml, respectively. The reference range obtained in the age group of >60 years was 0.14–3.8 ng/ml. Serum total PSA levels showed an increasing trend with increased age.

Conclusion:
Age-specific reference range of serum total PSA showing a positive correlation with age was established among the Indian Bengali male population.

Key words: Serum total PSA, Reference intervals, Age-specific PSA

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by Abhisek Das Choudhury Articles by Pradipta Ghosh Articles by Papia Sen Articles by Amrita Mukherjee
	on Google
	on Google Scholar

How to Cite this Article

Pubmed Style

Choudhury AD, Ghosh P, Sen P, Mukherjee A. Establishment of an age-specific reference range for serum total prostate-specific antigen levels among the Indian Bengali male population in a tertiary care hospital. Natl J Physiol Pharm Pharmacol. 2025; 15(2): 162-166. doi:10.5455/NJPPP.2025.v15.i2.8

Web Style

Choudhury AD, Ghosh P, Sen P, Mukherjee A. Establishment of an age-specific reference range for serum total prostate-specific antigen levels among the Indian Bengali male population in a tertiary care hospital. https://www.njppp.com/?mno=216791 [Access: March 08, 2025]. doi:10.5455/NJPPP.2025.v15.i2.8

AMA (American Medical Association) Style

Choudhury AD, Ghosh P, Sen P, Mukherjee A. Establishment of an age-specific reference range for serum total prostate-specific antigen levels among the Indian Bengali male population in a tertiary care hospital. Natl J Physiol Pharm Pharmacol. 2025; 15(2): 162-166. doi:10.5455/NJPPP.2025.v15.i2.8

Vancouver/ICMJE Style

Choudhury AD, Ghosh P, Sen P, Mukherjee A. Establishment of an age-specific reference range for serum total prostate-specific antigen levels among the Indian Bengali male population in a tertiary care hospital. Natl J Physiol Pharm Pharmacol. (2025), [cited March 08, 2025]; 15(2): 162-166. doi:10.5455/NJPPP.2025.v15.i2.8

Harvard Style

Choudhury, A. D., Ghosh, . P., Sen, . P. & Mukherjee, . A. (2025) Establishment of an age-specific reference range for serum total prostate-specific antigen levels among the Indian Bengali male population in a tertiary care hospital. Natl J Physiol Pharm Pharmacol, 15 (2), 162-166. doi:10.5455/NJPPP.2025.v15.i2.8

Turabian Style

Choudhury, Abhisek Das, Pradipta Ghosh, Papia Sen, and Amrita Mukherjee. 2025. Establishment of an age-specific reference range for serum total prostate-specific antigen levels among the Indian Bengali male population in a tertiary care hospital. National Journal of Physiology, Pharmacy and Pharmacology, 15 (2), 162-166. doi:10.5455/NJPPP.2025.v15.i2.8

Chicago Style

Choudhury, Abhisek Das, Pradipta Ghosh, Papia Sen, and Amrita Mukherjee. "Establishment of an age-specific reference range for serum total prostate-specific antigen levels among the Indian Bengali male population in a tertiary care hospital." National Journal of Physiology, Pharmacy and Pharmacology 15 (2025), 162-166. doi:10.5455/NJPPP.2025.v15.i2.8

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Choudhury, A. D., Ghosh, . P., Sen, . P. & Mukherjee, . A. (2025) Establishment of an age-specific reference range for serum total prostate-specific antigen levels among the Indian Bengali male population in a tertiary care hospital. National Journal of Physiology, Pharmacy and Pharmacology, 15 (2), 162-166. doi:10.5455/NJPPP.2025.v15.i2.8

About National Journal of Physiology, Pharmacy and Pharmacology

Contact Information

How to cite this article