E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Exercise causes oxygen desaturation and hypercapnia in stable chronic obstructive pulmonary disease patients

Swapna Kanyadari, Shaktiprasad Hiremath, Khararashah Kammar.

Abstract
Background: Assessment of severity of chronic obstructive pulmonary disease (COPD) is the cornerstone of therapy. Spirometric measurements have traditionally remained as the popular diagnostic tool of choice. Oxygenation and carbon dioxide removal cannot be assessed by Spirometry alone, especially during exercise. Therefore, we studied whether desaturation and hypercapnea occur in response to exercise in COPD patients.

Aims and Objectives: To know whether bicycle pedaling as an exercise can unravel the gas exchange abnormalities and airflow limitation that might be precipitated by physical activity. This is done by estimating the changes in Oxygen saturation by pulse oximetry, and by estimating the changes in Blood CO2 levels by capnography.

Materials and Methods: Thirty stable COPD patients and controls were included for the study. Here we measured the change in oxygen saturation from rest to submaximal exercise (done using bicycle ergometry). Concomitantly, we measured the change in carbon dioxide levels of expired air from rest to submaximal exercise.

Results: We found that COPD patients experience oxygen desaturation. ΔSaO2 (difference between resting and exercise SaO2) was only 1% in controls whereas 8.86% in COPD. Hypercapnia occurred in response to a submaximal exercise in COPD patients (End tidal carbon dioxide of 48.87 mmHg). We also found that they become tachypneic and show greater degree of exhaustion.

Conclusion: Our study points out that exercise-induced desaturation and hypercapnia are a definite occurrence in COPD patients. It is a marker of progressive disease. It can be used as a form of stress test for the pulmonary system.

Key words: Chronic Obstructive Pulmonary Disease; Exercise Induced Desaturation; Exercise Induced Hypercapnia; Tachypnea


 
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How to Cite this Article
Pubmed Style

Kanyadari S, Hiremath S, Kammar K. Exercise causes oxygen desaturation and hypercapnia in stable chronic obstructive pulmonary disease patients. Natl J Physiol Pharm Pharmacol. 2022; 12(9): 1371-1374. doi:10.5455/njppp.2022.12.01018202215012022


Web Style

Kanyadari S, Hiremath S, Kammar K. Exercise causes oxygen desaturation and hypercapnia in stable chronic obstructive pulmonary disease patients. https://www.njppp.com/?mno=139495 [Access: November 24, 2022]. doi:10.5455/njppp.2022.12.01018202215012022


AMA (American Medical Association) Style

Kanyadari S, Hiremath S, Kammar K. Exercise causes oxygen desaturation and hypercapnia in stable chronic obstructive pulmonary disease patients. Natl J Physiol Pharm Pharmacol. 2022; 12(9): 1371-1374. doi:10.5455/njppp.2022.12.01018202215012022



Vancouver/ICMJE Style

Kanyadari S, Hiremath S, Kammar K. Exercise causes oxygen desaturation and hypercapnia in stable chronic obstructive pulmonary disease patients. Natl J Physiol Pharm Pharmacol. (2022), [cited November 24, 2022]; 12(9): 1371-1374. doi:10.5455/njppp.2022.12.01018202215012022



Harvard Style

Kanyadari, S., Hiremath, . S. & Kammar, . K. (2022) Exercise causes oxygen desaturation and hypercapnia in stable chronic obstructive pulmonary disease patients. Natl J Physiol Pharm Pharmacol, 12 (9), 1371-1374. doi:10.5455/njppp.2022.12.01018202215012022



Turabian Style

Kanyadari, Swapna, Shaktiprasad Hiremath, and Khararashah Kammar. 2022. Exercise causes oxygen desaturation and hypercapnia in stable chronic obstructive pulmonary disease patients. National Journal of Physiology, Pharmacy and Pharmacology, 12 (9), 1371-1374. doi:10.5455/njppp.2022.12.01018202215012022



Chicago Style

Kanyadari, Swapna, Shaktiprasad Hiremath, and Khararashah Kammar. "Exercise causes oxygen desaturation and hypercapnia in stable chronic obstructive pulmonary disease patients." National Journal of Physiology, Pharmacy and Pharmacology 12 (2022), 1371-1374. doi:10.5455/njppp.2022.12.01018202215012022



MLA (The Modern Language Association) Style

Kanyadari, Swapna, Shaktiprasad Hiremath, and Khararashah Kammar. "Exercise causes oxygen desaturation and hypercapnia in stable chronic obstructive pulmonary disease patients." National Journal of Physiology, Pharmacy and Pharmacology 12.9 (2022), 1371-1374. Print. doi:10.5455/njppp.2022.12.01018202215012022



APA (American Psychological Association) Style

Kanyadari, S., Hiremath, . S. & Kammar, . K. (2022) Exercise causes oxygen desaturation and hypercapnia in stable chronic obstructive pulmonary disease patients. National Journal of Physiology, Pharmacy and Pharmacology, 12 (9), 1371-1374. doi:10.5455/njppp.2022.12.01018202215012022