Attenuation of hemodynamic responses to laryngoscopy and intubation by pre-operative oral melatonin

Manjunatha K R; Muralidhara Danappa Patel; Ramesh Kumar N; Bharathi K S

doi:10.5455/njppp.2023.13.01031202315032023

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Original Research
Online Published: 23 Mar 2023

Natl J Physiol Pharm Pharmacol. 2023; 13(4): 876-879

doi: 10.5455/njppp.2023.13.01031202315032023

Attenuation of hemodynamic responses to laryngoscopy and intubation by pre-operative oral melatonin

Manjunatha K R, Muralidhara Danappa Patel, Ramesh Kumar N, Bharathi K S.

Abstract
Background: Laryngoscopy and endotracheal intubation are usually associated with tachycardia and hypertension. Pre-administration of melatonin has anxiolytic and sedative property which can reduce the tachycardia and hypertension during the surgical procedures.

Aims and Objectives: The present study aimed to evaluate the melatonin effect on hemodynamic changes during laryngoscopy and intubation.

Materials and Methods: This prospective study was done in the department of anesthesia, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bengaluru, Karnataka. Total 80 patients were included in the study based on the inclusion and exclusion criteria. Patients were divided into two groups. Group-A treated with placebo and Group-B treated with melatonin (6 mg) and demographic, clinical, and hemodynamic parameters were recorded. The data were analyzed with unpaired t-test with the use SPSS (20.0) version software.

Results: Comparison of number and percentage of age, gender, and blood groups between the Group-I and Group-II not showed any significant difference. Group-I and Group-II mean age, height, and weight not showed any significant difference. Mean heart rate, systolic blood pressure, diastolic blood pressure, and mean arterial pressure were compared between the Group-I and Group-II at basal, during, after 1, 3, 5, and 10 min showed significant difference.

Conclusion: Pre-administration melatonin showed significant reduction of hemodynamic changes compared to placebo group.

Key words: Hemodynamic Responses; Laryngoscopy; Intubation; Pre-operative; Melatonin

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Pubmed Style

R MK, Patel MD, N RK, S BK. Attenuation of hemodynamic responses to laryngoscopy and intubation by pre-operative oral melatonin. Natl J Physiol Pharm Pharmacol. 2023; 13(4): 876-879. doi:10.5455/njppp.2023.13.01031202315032023

Web Style

R MK, Patel MD, N RK, S BK. Attenuation of hemodynamic responses to laryngoscopy and intubation by pre-operative oral melatonin. https://www.njppp.com/?mno=136751 [Access: March 08, 2025]. doi:10.5455/njppp.2023.13.01031202315032023

AMA (American Medical Association) Style

R MK, Patel MD, N RK, S BK. Attenuation of hemodynamic responses to laryngoscopy and intubation by pre-operative oral melatonin. Natl J Physiol Pharm Pharmacol. 2023; 13(4): 876-879. doi:10.5455/njppp.2023.13.01031202315032023

Vancouver/ICMJE Style

R MK, Patel MD, N RK, S BK. Attenuation of hemodynamic responses to laryngoscopy and intubation by pre-operative oral melatonin. Natl J Physiol Pharm Pharmacol. (2023), [cited March 08, 2025]; 13(4): 876-879. doi:10.5455/njppp.2023.13.01031202315032023

Harvard Style

R, M. K., Patel, . M. D., N, . R. K. & S, . B. K. (2023) Attenuation of hemodynamic responses to laryngoscopy and intubation by pre-operative oral melatonin. Natl J Physiol Pharm Pharmacol, 13 (4), 876-879. doi:10.5455/njppp.2023.13.01031202315032023

Turabian Style

R, Manjunatha K, Muralidhara Danappa Patel, Ramesh Kumar N, and Bharathi K S. 2023. Attenuation of hemodynamic responses to laryngoscopy and intubation by pre-operative oral melatonin. National Journal of Physiology, Pharmacy and Pharmacology, 13 (4), 876-879. doi:10.5455/njppp.2023.13.01031202315032023

Chicago Style

R, Manjunatha K, Muralidhara Danappa Patel, Ramesh Kumar N, and Bharathi K S. "Attenuation of hemodynamic responses to laryngoscopy and intubation by pre-operative oral melatonin." National Journal of Physiology, Pharmacy and Pharmacology 13 (2023), 876-879. doi:10.5455/njppp.2023.13.01031202315032023

MLA (The Modern Language Association) Style

R, Manjunatha K, Muralidhara Danappa Patel, Ramesh Kumar N, and Bharathi K S. "Attenuation of hemodynamic responses to laryngoscopy and intubation by pre-operative oral melatonin." National Journal of Physiology, Pharmacy and Pharmacology 13.4 (2023), 876-879. Print. doi:10.5455/njppp.2023.13.01031202315032023

APA (American Psychological Association) Style

R, M. K., Patel, . M. D., N, . R. K. & S, . B. K. (2023) Attenuation of hemodynamic responses to laryngoscopy and intubation by pre-operative oral melatonin. National Journal of Physiology, Pharmacy and Pharmacology, 13 (4), 876-879. doi:10.5455/njppp.2023.13.01031202315032023

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