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Original Research 


A cross-sectional study to know the prevalence of thyroid dysfunction in systemic lupus erythematosus

Rakesh Anand, Partha Mandal, Narendra Nath Hait, Brahmarshi Das.

Abstract
Background: Systemic lupus erythematosus (SLE) is a persistent autoimmune disease, the pathogenesis of which remains elusive. Autoimmune factors may be a cause of SLE and thyroid dysfunction. Many studies have revealed that the prevalence of thyroid disorder is higher in SLE patients than in the general population. SLE is a multisystem and hypothyroidism is an organ specific autoimmune disorder and can occur successively or simultaneously.

Aims and Objectives: The aim of the study was to study the prevalence of thyroid disorder in patients with SLE.

Materials and Methods: Patients admitted with definite clinical features of SLE and Antinuclear Antibodies positive, in medicine ward and healthy blood donors are taken as control. Sample was tested by fully automated analyzer.

Results: Subclinical hypothyroidism was found in 24% of study group and 8% of control group which is statistically significant. Central and secondary hyperthyroidism was found in 10% of study group and 12% of control group but it was statistically insignificant. Several studies have documented an association between SLE and other autoimmune diseases such as Sjogren’s syndrome, autoimmune hemolytic anemia, and antiphospholipid syndrome. Subclinical hypothyroidism was higher than another thyroid dysfunction such as primary, central, and subclinical hypothyroidism was found to be higher in frequency, probably depicting the slow destructive process which is pathognomic of autoimmune thyroiditis.

Conclusion: Subclinical hypothyroidism was more prevalent in SLE than that of overt hypothyroidism as compared with general population.

Key words: Systemic Lupus Erythematosus; Hypothyroidism; Autoimmunity


 
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How to Cite this Article
Pubmed Style

Anand R, Mandal P, Hait NN, Das B. A cross-sectional study to know the prevalence of thyroid dysfunction in systemic lupus erythematosus. Natl J Physiol Pharm Pharmacol. 2023; 13(2): 384-387. doi:10.5455/njppp.2023.13.12604202230122022

Web Style

Anand R, Mandal P, Hait NN, Das B. A cross-sectional study to know the prevalence of thyroid dysfunction in systemic lupus erythematosus. https://www.njppp.com/?mno=117661 [Access: September 03, 2023]. doi:10.5455/njppp.2023.13.12604202230122022

AMA (American Medical Association) Style

Anand R, Mandal P, Hait NN, Das B. A cross-sectional study to know the prevalence of thyroid dysfunction in systemic lupus erythematosus. Natl J Physiol Pharm Pharmacol. 2023; 13(2): 384-387. doi:10.5455/njppp.2023.13.12604202230122022


Vancouver/ICMJE Style

Anand R, Mandal P, Hait NN, Das B. A cross-sectional study to know the prevalence of thyroid dysfunction in systemic lupus erythematosus. Natl J Physiol Pharm Pharmacol. (2023), [cited September 03, 2023]; 13(2): 384-387. doi:10.5455/njppp.2023.13.12604202230122022


Harvard Style

Anand, R., Mandal, . P., Hait, . N. N. & Das, . B. (2023) A cross-sectional study to know the prevalence of thyroid dysfunction in systemic lupus erythematosus. Natl J Physiol Pharm Pharmacol, 13 (2), 384-387. doi:10.5455/njppp.2023.13.12604202230122022


Turabian Style

Anand, Rakesh, Partha Mandal, Narendra Nath Hait, and Brahmarshi Das. 2023. A cross-sectional study to know the prevalence of thyroid dysfunction in systemic lupus erythematosus. National Journal of Physiology, Pharmacy and Pharmacology, 13 (2), 384-387. doi:10.5455/njppp.2023.13.12604202230122022


Chicago Style

Anand, Rakesh, Partha Mandal, Narendra Nath Hait, and Brahmarshi Das. "A cross-sectional study to know the prevalence of thyroid dysfunction in systemic lupus erythematosus." National Journal of Physiology, Pharmacy and Pharmacology 13 (2023), 384-387. doi:10.5455/njppp.2023.13.12604202230122022


MLA (The Modern Language Association) Style

Anand, Rakesh, Partha Mandal, Narendra Nath Hait, and Brahmarshi Das. "A cross-sectional study to know the prevalence of thyroid dysfunction in systemic lupus erythematosus." National Journal of Physiology, Pharmacy and Pharmacology 13.2 (2023), 384-387. Print. doi:10.5455/njppp.2023.13.12604202230122022


APA (American Psychological Association) Style

Anand, R., Mandal, . P., Hait, . N. N. & Das, . B. (2023) A cross-sectional study to know the prevalence of thyroid dysfunction in systemic lupus erythematosus. National Journal of Physiology, Pharmacy and Pharmacology, 13 (2), 384-387. doi:10.5455/njppp.2023.13.12604202230122022


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