Evaluation of anti-diabetic and anti-inflammatory activities of Fenugreek (Trigonella foenum-graecum) seed extracts on Albino Wistar Rats

Venkatnarayana Narapogu; Swathi C; Madhukar Rao Polsani; John Premendran

doi:10.5455/njppp.2021.11.07221202114092021

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Natl J Physiol Pharm Pharmacol. 2021; 11(11): 1277-1282

doi: 10.5455/njppp.2021.11.07221202114092021

Evaluation of anti-diabetic and anti-inflammatory activities of Fenugreek (Trigonella foenum-graecum) seed extracts on Albino Wistar Rats

Venkatnarayana Narapogu, Swathi C, Madhukar Rao Polsani, John Premendran.

Abstract
Background: Fenugreek (Trigonella Foenum-Graecum) is a compound used since ancient times in Indian folk medicine for several medicinal properties. It has been known to produce hypoglycemic and antioxidant actions.

Aim and Objective: This
study aimed to determine ethanolic extracts out of fenugreek seeds for the anti-diabetic including anti-inflammatory effects on Wister rats.

Materials and Methods: Inbred Albino male and female Wistar rats were used for the study. The powdered seeds were extracted with 90% ethanol by Soxhelation (100 g) for 34 days. The diabetes was assessed after 72 h of alloxan-induced to rats by determining the blood sugar level. Rat Paw volume was measured to the ankle joint in drug-treated and untreated groups at 0 min, 30 min, 60 min, and 120 mins using carrageenan challenge measured mercury plethysmograph.

Results: Fenugreek at 200 mg/kg dose and 400 mg/kg decreased blood glucose which was dose-dependent. The reductions in blood glucose levels (BGLs) were significant post 14th day in both groups. The antiinflammatory activity Fenugreek 200 mg/kg did not significantly reduce paw volume. Fenugreek at the dose of 400 mg/kg demonstrated inhibition of paw volume to 39.076% at the end of 2 h which was lesser than standard drug Aspirin.

Conclusion: T. foenum-graecum decreased blood glucose towards the end of 21 days reduced the BGLs like the standard drug Gliclazide. The anti-inflammatory actions of the extracts were not found to be significant at the dose of 200 mg/kg and moderate anti-inflammatory actions at the dose of 400 mg/kg compared to standard drug Aspirin.

Key words: Fenugreek; Trigonella foenum-graecum; Anti-diabetic; Anti-inflammatory; Ethanolic extracts

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Pubmed Style

Narapogu V, C S, Polsani MR, Premendran J. Evaluation of anti-diabetic and anti-inflammatory activities of Fenugreek (Trigonella foenum-graecum) seed extracts on Albino Wistar Rats. Natl J Physiol Pharm Pharmacol. 2021; 11(11): 1277-1282. doi:10.5455/njppp.2021.11.07221202114092021

Web Style

Narapogu V, C S, Polsani MR, Premendran J. Evaluation of anti-diabetic and anti-inflammatory activities of Fenugreek (Trigonella foenum-graecum) seed extracts on Albino Wistar Rats. https://www.njppp.com/?mno=92395 [Access: March 14, 2024]. doi:10.5455/njppp.2021.11.07221202114092021

AMA (American Medical Association) Style

Narapogu V, C S, Polsani MR, Premendran J. Evaluation of anti-diabetic and anti-inflammatory activities of Fenugreek (Trigonella foenum-graecum) seed extracts on Albino Wistar Rats. Natl J Physiol Pharm Pharmacol. 2021; 11(11): 1277-1282. doi:10.5455/njppp.2021.11.07221202114092021

Vancouver/ICMJE Style

Narapogu V, C S, Polsani MR, Premendran J. Evaluation of anti-diabetic and anti-inflammatory activities of Fenugreek (Trigonella foenum-graecum) seed extracts on Albino Wistar Rats. Natl J Physiol Pharm Pharmacol. (2021), [cited March 14, 2024]; 11(11): 1277-1282. doi:10.5455/njppp.2021.11.07221202114092021

Harvard Style

Narapogu, V., C, . S., Polsani, . M. R. & Premendran, . J. (2021) Evaluation of anti-diabetic and anti-inflammatory activities of Fenugreek (Trigonella foenum-graecum) seed extracts on Albino Wistar Rats. Natl J Physiol Pharm Pharmacol, 11 (11), 1277-1282. doi:10.5455/njppp.2021.11.07221202114092021

Turabian Style

Narapogu, Venkatnarayana, Swathi C, Madhukar Rao Polsani, and John Premendran. 2021. Evaluation of anti-diabetic and anti-inflammatory activities of Fenugreek (Trigonella foenum-graecum) seed extracts on Albino Wistar Rats. National Journal of Physiology, Pharmacy and Pharmacology, 11 (11), 1277-1282. doi:10.5455/njppp.2021.11.07221202114092021

Chicago Style

Narapogu, Venkatnarayana, Swathi C, Madhukar Rao Polsani, and John Premendran. "Evaluation of anti-diabetic and anti-inflammatory activities of Fenugreek (Trigonella foenum-graecum) seed extracts on Albino Wistar Rats." National Journal of Physiology, Pharmacy and Pharmacology 11 (2021), 1277-1282. doi:10.5455/njppp.2021.11.07221202114092021

MLA (The Modern Language Association) Style

Narapogu, Venkatnarayana, Swathi C, Madhukar Rao Polsani, and John Premendran. "Evaluation of anti-diabetic and anti-inflammatory activities of Fenugreek (Trigonella foenum-graecum) seed extracts on Albino Wistar Rats." National Journal of Physiology, Pharmacy and Pharmacology 11.11 (2021), 1277-1282. Print. doi:10.5455/njppp.2021.11.07221202114092021

APA (American Psychological Association) Style

Narapogu, V., C, . S., Polsani, . M. R. & Premendran, . J. (2021) Evaluation of anti-diabetic and anti-inflammatory activities of Fenugreek (Trigonella foenum-graecum) seed extracts on Albino Wistar Rats. National Journal of Physiology, Pharmacy and Pharmacology, 11 (11), 1277-1282. doi:10.5455/njppp.2021.11.07221202114092021

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