Current theories of pathophysiology and potential therapeutic targets of COVID-19: What we know so far

Megha Agrawal; Gyan Vardhan; Vikas Kumar; Puneet Dhamija

doi:10.5455/njppp.2022.12.05135202223052022

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30 / 05 / 2022

Natl J Physiol Pharm Pharmacol. 2022; 12(7): 907-915

doi: 10.5455/njppp.2022.12.05135202223052022

Current theories of pathophysiology and potential therapeutic targets of COVID-19: What we know so far

Megha Agrawal, Gyan Vardhan, Vikas Kumar, Puneet Dhamija.

Abstract
In 2019, a new variant of coronavirus emerged that put the whole world on a standstill due to its unprecedented spread and morbidity. Since then, scientists have been working on several theories to explain the origin and pathogenesis of the virus. Over this period of time, it has been observed clinically that individual variation exists in the way this virus infects people, its symptomatology and sequelae. The pathophysiology is still unclear. This review was taken up to consolidate all the available information until date about current theories of etiopathogenesis with an understanding of potential therapeutic targets on the mechanisms. This review also highlights the gray areas that need to be addressed in the future. Research papers published up to December 7, 2020 were included based on a search on PubMed, Google Scholar, etc., to get the latest relevant literature on this topic. Coronavirus expresses differently in different individuals, affecting different organ systems, and having variable severity. However, the underlying pathogenic mechanisms are not completely understood. Due to the lack of definite curative therapy, it is essential to explore the basic pathophysiology so as to develop more effective and target-based therapies in the future.

Key words: COVID-19; Current Theories; Pathophysiology; Potential Targets; Etiopathogenesis; Unprecedented Spread

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Pubmed Style

Agrawal M, Vardhan G, Kumar V, Dhamija P. Current theories of pathophysiology and potential therapeutic targets of COVID-19: What we know so far. Natl J Physiol Pharm Pharmacol. 2022; 12(7): 907-915. doi:10.5455/njppp.2022.12.05135202223052022

Web Style

Agrawal M, Vardhan G, Kumar V, Dhamija P. Current theories of pathophysiology and potential therapeutic targets of COVID-19: What we know so far. https://www.njppp.com/?mno=78340 [Access: March 15, 2024]. doi:10.5455/njppp.2022.12.05135202223052022

AMA (American Medical Association) Style

Agrawal M, Vardhan G, Kumar V, Dhamija P. Current theories of pathophysiology and potential therapeutic targets of COVID-19: What we know so far. Natl J Physiol Pharm Pharmacol. 2022; 12(7): 907-915. doi:10.5455/njppp.2022.12.05135202223052022

Vancouver/ICMJE Style

Agrawal M, Vardhan G, Kumar V, Dhamija P. Current theories of pathophysiology and potential therapeutic targets of COVID-19: What we know so far. Natl J Physiol Pharm Pharmacol. (2022), [cited March 15, 2024]; 12(7): 907-915. doi:10.5455/njppp.2022.12.05135202223052022

Harvard Style

Agrawal, M., Vardhan, . G., Kumar, . V. & Dhamija, . P. (2022) Current theories of pathophysiology and potential therapeutic targets of COVID-19: What we know so far. Natl J Physiol Pharm Pharmacol, 12 (7), 907-915. doi:10.5455/njppp.2022.12.05135202223052022

Turabian Style

Agrawal, Megha, Gyan Vardhan, Vikas Kumar, and Puneet Dhamija. 2022. Current theories of pathophysiology and potential therapeutic targets of COVID-19: What we know so far. National Journal of Physiology, Pharmacy and Pharmacology, 12 (7), 907-915. doi:10.5455/njppp.2022.12.05135202223052022

Chicago Style

Agrawal, Megha, Gyan Vardhan, Vikas Kumar, and Puneet Dhamija. "Current theories of pathophysiology and potential therapeutic targets of COVID-19: What we know so far." National Journal of Physiology, Pharmacy and Pharmacology 12 (2022), 907-915. doi:10.5455/njppp.2022.12.05135202223052022

MLA (The Modern Language Association) Style

Agrawal, Megha, Gyan Vardhan, Vikas Kumar, and Puneet Dhamija. "Current theories of pathophysiology and potential therapeutic targets of COVID-19: What we know so far." National Journal of Physiology, Pharmacy and Pharmacology 12.7 (2022), 907-915. Print. doi:10.5455/njppp.2022.12.05135202223052022

APA (American Psychological Association) Style

Agrawal, M., Vardhan, . G., Kumar, . V. & Dhamija, . P. (2022) Current theories of pathophysiology and potential therapeutic targets of COVID-19: What we know so far. National Journal of Physiology, Pharmacy and Pharmacology, 12 (7), 907-915. doi:10.5455/njppp.2022.12.05135202223052022

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