Comparison of calculated low-density lipoprotein-cholesterol by Friedwald’s equation and direct low-density lipoprotein-cholesterol by homogenous assay

Anuj Satishkumar Modi; Heratkumar Dineshchandra Soni; Sandipkumar Rajeshbhai Patel

doi:10.5455/njppp.2022.12.03151202207042022

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Original Research
Online Published: 16 Apr 2022

Natl J Physiol Pharm Pharmacol. 2022; 12(12): 2026-2028

doi: 10.5455/njppp.2022.12.03151202207042022

Comparison of calculated low-density lipoprotein-cholesterol by Friedwald’s equation and direct low-density lipoprotein-cholesterol by homogenous assay

Anuj Satishkumar Modi, Heratkumar Dineshchandra Soni, Sandipkumar Rajeshbhai Patel.

Abstract
Background: LDL cholesterol is a known atherogenic factor and basis for risk classification of coronary heart disease. Reference method for measurement is beta-quantitation which is laborious and time consuming. The other method for measurement is direct homogenous assay which is costly so most laboratories use Friedwald’s formula for LDL measurement.

Aim and Objectives: The aim of the study was to compare between calculated LDL by Friedwald’s formula and direct LDL by homogenous assay in fasting lipid profile samples.

Material and Methods: We have taken data of 208 fasting lipid profile from past records after obtaining Institutional Ethics Committee permission. Patients with TG > 400 mg/dl were excluded from the study.

Results: In our study, Pearson’s coefficient is 0.97 when TG < 200 mg/dl and Pearson’s coefficient is 0.95 when TG > 200 mg/dl. There is a less difference in patient’s risk classification by calculated LDL and direct LDL when TG < 200 mg/dl.

Conclusion: Friedwald’s formula is a cost-effective method for measurement of LDL in comparison to homogenous assays. We can use calculated LDL when TG < 200 mg/dl without any risk of patient’s misclassification.

Key words: LDL-cholesterol; Friedwald’s Formula; Homogenous Assay

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Pubmed Style

Modi AS, Soni HD, Patel SR. Comparison of calculated low-density lipoprotein-cholesterol by Friedwald’s equation and direct low-density lipoprotein-cholesterol by homogenous assay. Natl J Physiol Pharm Pharmacol. 2022; 12(12): 2026-2028. doi:10.5455/njppp.2022.12.03151202207042022

Web Style

Modi AS, Soni HD, Patel SR. Comparison of calculated low-density lipoprotein-cholesterol by Friedwald’s equation and direct low-density lipoprotein-cholesterol by homogenous assay. https://www.njppp.com/?mno=5516 [Access: May 07, 2025]. doi:10.5455/njppp.2022.12.03151202207042022

AMA (American Medical Association) Style

Modi AS, Soni HD, Patel SR. Comparison of calculated low-density lipoprotein-cholesterol by Friedwald’s equation and direct low-density lipoprotein-cholesterol by homogenous assay. Natl J Physiol Pharm Pharmacol. 2022; 12(12): 2026-2028. doi:10.5455/njppp.2022.12.03151202207042022

Vancouver/ICMJE Style

Modi AS, Soni HD, Patel SR. Comparison of calculated low-density lipoprotein-cholesterol by Friedwald’s equation and direct low-density lipoprotein-cholesterol by homogenous assay. Natl J Physiol Pharm Pharmacol. (2022), [cited May 07, 2025]; 12(12): 2026-2028. doi:10.5455/njppp.2022.12.03151202207042022

Harvard Style

Modi, A. S., Soni, . H. D. & Patel, . S. R. (2022) Comparison of calculated low-density lipoprotein-cholesterol by Friedwald’s equation and direct low-density lipoprotein-cholesterol by homogenous assay. Natl J Physiol Pharm Pharmacol, 12 (12), 2026-2028. doi:10.5455/njppp.2022.12.03151202207042022

Turabian Style

Modi, Anuj Satishkumar, Heratkumar Dineshchandra Soni, and Sandipkumar Rajeshbhai Patel. 2022. Comparison of calculated low-density lipoprotein-cholesterol by Friedwald’s equation and direct low-density lipoprotein-cholesterol by homogenous assay. National Journal of Physiology, Pharmacy and Pharmacology, 12 (12), 2026-2028. doi:10.5455/njppp.2022.12.03151202207042022

Chicago Style

Modi, Anuj Satishkumar, Heratkumar Dineshchandra Soni, and Sandipkumar Rajeshbhai Patel. "Comparison of calculated low-density lipoprotein-cholesterol by Friedwald’s equation and direct low-density lipoprotein-cholesterol by homogenous assay." National Journal of Physiology, Pharmacy and Pharmacology 12 (2022), 2026-2028. doi:10.5455/njppp.2022.12.03151202207042022

MLA (The Modern Language Association) Style

Modi, Anuj Satishkumar, Heratkumar Dineshchandra Soni, and Sandipkumar Rajeshbhai Patel. "Comparison of calculated low-density lipoprotein-cholesterol by Friedwald’s equation and direct low-density lipoprotein-cholesterol by homogenous assay." National Journal of Physiology, Pharmacy and Pharmacology 12.12 (2022), 2026-2028. Print. doi:10.5455/njppp.2022.12.03151202207042022

APA (American Psychological Association) Style

Modi, A. S., Soni, . H. D. & Patel, . S. R. (2022) Comparison of calculated low-density lipoprotein-cholesterol by Friedwald’s equation and direct low-density lipoprotein-cholesterol by homogenous assay. National Journal of Physiology, Pharmacy and Pharmacology, 12 (12), 2026-2028. doi:10.5455/njppp.2022.12.03151202207042022

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