Abstract
Background: Lysine is a basic amino acid which is not integrated inside the body. It is integrated in higher plants through biochemical pathways. Numerous clinical studies have revealed that amino acids assume a significant part in rushing the way toward wound recuperating by improving the nearby blood supply as growth factors.

Aim and Objectives: This investigation intended to evaluate the wound healing potential, efficacy, and tolerability of lysine cream (15%) in diabetic foot ulcer assessed by assessing scale.

Materials and Methods: A randomized, open-label, and interventional study was directed on 40 subjects (participants) with diabetic ulcers. Participants were grouped into two groups, control and test. The control group (n = 20) was treated with standard treatment and the test group was treated with standard treatment alongside lysine cream (15%) twice every day. Wound healing in the participants was assessed by the assessing scales.

Results: A total of 40 participants were allotted into two groups. The results expressed as mean ± standard deviation values imply the size and depth of the foot ulcer from the 1st week to the 8th week. Both the groups showed a significant increase the ulcer healing and decrease the pressure of foot ulcer of over a period of 8 weeks. The assessment of the 1st week showed no significant ulcer healing and its pressure. The overall outcome indicated that the lysine-treated group extensively reduced each of the parameters favoring wound healing than the standard therapy alone (control group). Furthermore, there was no significant difference in the blood glucose levels in both study groups.

Conclusion: Treatment with additional lysine cream considerably improved wound recovery in diabetic foot ulcer patients when compared to the standard therapy alone.