Correlation of serum creatinine and urea with glycemic index and duration of diabetes in Type 1 and Type 2 diabetes mellitus: A comparative study

Arun Chutani; Sonali Pande

doi:10.5455/njppp.2017.7.0515606052017

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Online Published: 16 May 2017

Natl J Physiol Pharm Pharmacol. 2017; 7(9): 914-919

doi: 10.5455/njppp.2017.7.0515606052017

Correlation of serum creatinine and urea with glycemic index and duration of diabetes in Type 1 and Type 2 diabetes mellitus: A comparative study

Arun Chutani, Sonali Pande.

Cited By:76

Abstract
Background: Diabetes is a common cause of end-stage renal disease and nephropathy, which is characterized by abnormal renal function with reduction of glomerular filtration and rise in the level of serum urea and creatinine.

Aims and Objectives: The aim of this study was to compare serum urea and creatinine levels in Type 1 and Type 2 diabetics and further correlate the serum creatinine and urea levels in both Type 1 and Type 2 diabetic subjects with duration of diabetes and glycosylated hemoglobin levels (HbA1c).

Materials and Methods: Blood samples were collected and analyzed for serum urea and creatinine levels in diabetic subjects, both Type 1 and Type 2 attending diabetic clinic and non-diabetic subjects in a tertiary hospital. 72 male subjects in each group of age 35-55 years were selected for the study. Fasting, post-meal blood sugar levels, and HbA1c of all the subjects in the study were determined. Results were interpreted by one-way analysis of variance test. Association of serum urea and creatinine levels with HbA1c and duration of illness in all diabetic subjects was analyzed by applying Pearsons correlation coefficient.

Results: There was statistically significant increase in serum urea and creatinine levels in both Type 1 and Type 2 diabetic subjects compared to non-diabetic subjects. There was a correlation of levels of serum urea and creatinine with HbA1c levels and duration of diabetes in Type 1 diabetics but not with Type 2 diabetic study group.

Conclusion: Serum urea and creatinine are simple and useful biomarkers which can serve as predictor tests for assessing kidney functions (nephropathy) in diabetic patients.

Key words: Blood Urea; Creatinine; Type 1 Diabetes; Type 2 Diabetes; Nephropathy; Glycosylated Hemoglobin

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Pubmed Style

Chutani A, Pande S. Correlation of serum creatinine and urea with glycemic index and duration of diabetes in Type 1 and Type 2 diabetes mellitus: A comparative study. Natl J Physiol Pharm Pharmacol. 2017; 7(9): 914-919. doi:10.5455/njppp.2017.7.0515606052017

Web Style

Chutani A, Pande S. Correlation of serum creatinine and urea with glycemic index and duration of diabetes in Type 1 and Type 2 diabetes mellitus: A comparative study. https://www.njppp.com/?mno=266080 [Access: November 01, 2025]. doi:10.5455/njppp.2017.7.0515606052017

AMA (American Medical Association) Style

Chutani A, Pande S. Correlation of serum creatinine and urea with glycemic index and duration of diabetes in Type 1 and Type 2 diabetes mellitus: A comparative study. Natl J Physiol Pharm Pharmacol. 2017; 7(9): 914-919. doi:10.5455/njppp.2017.7.0515606052017

Vancouver/ICMJE Style

Chutani A, Pande S. Correlation of serum creatinine and urea with glycemic index and duration of diabetes in Type 1 and Type 2 diabetes mellitus: A comparative study. Natl J Physiol Pharm Pharmacol. (2017), [cited November 01, 2025]; 7(9): 914-919. doi:10.5455/njppp.2017.7.0515606052017

Harvard Style

Chutani, A. & Pande, . S. (2017) Correlation of serum creatinine and urea with glycemic index and duration of diabetes in Type 1 and Type 2 diabetes mellitus: A comparative study. Natl J Physiol Pharm Pharmacol, 7 (9), 914-919. doi:10.5455/njppp.2017.7.0515606052017

Turabian Style

Chutani, Arun, and Sonali Pande. 2017. Correlation of serum creatinine and urea with glycemic index and duration of diabetes in Type 1 and Type 2 diabetes mellitus: A comparative study. National Journal of Physiology, Pharmacy and Pharmacology, 7 (9), 914-919. doi:10.5455/njppp.2017.7.0515606052017

Chicago Style

Chutani, Arun, and Sonali Pande. "Correlation of serum creatinine and urea with glycemic index and duration of diabetes in Type 1 and Type 2 diabetes mellitus: A comparative study." National Journal of Physiology, Pharmacy and Pharmacology 7 (2017), 914-919. doi:10.5455/njppp.2017.7.0515606052017

MLA (The Modern Language Association) Style

Chutani, Arun, and Sonali Pande. "Correlation of serum creatinine and urea with glycemic index and duration of diabetes in Type 1 and Type 2 diabetes mellitus: A comparative study." National Journal of Physiology, Pharmacy and Pharmacology 7.9 (2017), 914-919. Print. doi:10.5455/njppp.2017.7.0515606052017

APA (American Psychological Association) Style

Chutani, A. & Pande, . S. (2017) Correlation of serum creatinine and urea with glycemic index and duration of diabetes in Type 1 and Type 2 diabetes mellitus: A comparative study. National Journal of Physiology, Pharmacy and Pharmacology, 7 (9), 914-919. doi:10.5455/njppp.2017.7.0515606052017

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