The use of reversibility percent in spirometric assessment of chronic obstructive pulmonary diseases for the detrimental effect of 3rd generation beta-blockers

Ali Salih Baay

doi:10.5455/njppp.2017.7.01235023012017

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Original Research
Online Published: 06 Mar 2017

Natl J Physiol Pharm Pharmacol. 2017; 7(6): 628-633

doi: 10.5455/njppp.2017.7.01235023012017

The use of reversibility percent in spirometric assessment of chronic obstructive pulmonary diseases for the detrimental effect of 3rd generation beta-blockers

Ali Salih Baay.

Abstract
Background: For clinicians who work in respiratory medicine, the use of beta-blockers (BBs) has, for a long time, posed a dilemma because of the potential risk of bronchospasm and neutralization of the effectiveness of β-2 agonists.

Aims and Objectives: To observe the effect of nebivolol on clinical and spirometric parameters on patients with stable chronic obstructive pulmonary disease (COPD) and the effect of the reversibility magnitude on the nebivolol detrimental effects.

Materials and Methods: A total of 32 patients with age above 40 years regardless their smoking state from both genders were included in the study at College of Medicine, Babylon University from February 2014 to September 2016. The study was approved by Institutional Review Board. The study included the patients who were diagnosed as COPD. Patients were divided into two groups depending on the reversibility test in spirometric assessment.

Results: There were significant differences between means of forced expiratory flow (FEF), forced expiratory volume in 1 second (FEV1) and COPD assessment test (CAT) score before and after using of 3rd generation BB for all patients with COPD and patients with high reversibility percent while for patients with low reversibility percent were significant differences between means of FEF, while there were no significant differences between means of FEV1 and CAT score.

Conclusion: The reversibility percent can be used as an indicator for the adverse effect of BB on COPD patients.

Key words: Reversibility Test; Chronic Obstructive Pulmonary Disease; Nebivolol; Outcome Predictor

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Pubmed Style

Ali Salih Baay. The use of reversibility percent in spirometric assessment of chronic obstructive pulmonary diseases for the detrimental effect of 3rd generation beta-blockers. Natl J Physiol Pharm Pharmacol. 2017; 7(6): 628-633.

doi:10.5455/njppp.2017.7.01235023012017

Web Style

Ali Salih Baay. The use of reversibility percent in spirometric assessment of chronic obstructive pulmonary diseases for the detrimental effect of 3rd generation beta-blockers. https://www.njppp.com/?mno=253089 [Access: June 27, 2026].

doi:10.5455/njppp.2017.7.01235023012017

AMA (American Medical Association) Style

Ali Salih Baay. The use of reversibility percent in spirometric assessment of chronic obstructive pulmonary diseases for the detrimental effect of 3rd generation beta-blockers. Natl J Physiol Pharm Pharmacol. 2017; 7(6): 628-633.

doi:10.5455/njppp.2017.7.01235023012017

Vancouver/ICMJE Style

Ali Salih Baay. The use of reversibility percent in spirometric assessment of chronic obstructive pulmonary diseases for the detrimental effect of 3rd generation beta-blockers. Natl J Physiol Pharm Pharmacol. (2017), [cited June 27, 2026]; 7(6): 628-633.

doi:10.5455/njppp.2017.7.01235023012017

Harvard Style

Ali Salih Baay (2017) The use of reversibility percent in spirometric assessment of chronic obstructive pulmonary diseases for the detrimental effect of 3rd generation beta-blockers. Natl J Physiol Pharm Pharmacol, 7 (6), 628-633.

doi:10.5455/njppp.2017.7.01235023012017

Turabian Style

Ali Salih Baay. 2017. The use of reversibility percent in spirometric assessment of chronic obstructive pulmonary diseases for the detrimental effect of 3rd generation beta-blockers. National Journal of Physiology, Pharmacy and Pharmacology, 7 (6), 628-633.

doi:10.5455/njppp.2017.7.01235023012017

Chicago Style

Ali Salih Baay. "The use of reversibility percent in spirometric assessment of chronic obstructive pulmonary diseases for the detrimental effect of 3rd generation beta-blockers." National Journal of Physiology, Pharmacy and Pharmacology 7 (2017), 628-633.

doi:10.5455/njppp.2017.7.01235023012017

MLA (The Modern Language Association) Style

doi:10.5455/njppp.2017.7.01235023012017

APA (American Psychological Association) Style

doi:10.5455/njppp.2017.7.01235023012017

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