E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research
Online Published: 25 May 2016
 


Effect of topical sodium fusidate, calcium mupirocin and papain—urea on wound healing in diabetic wistar rats

Smita Shenoy, Raghu Murthy, Lalit Mohan, Amoolya Gowda, Venu Madhav Nelluri.


Cited By:1

Abstract
Background: Poor wound healing is a complication of diabetes mellitus. Various agents have been used to promote wound healing in diabetic patients. Papain urea is used as a sloughing agent, whereas sodium fusidate and calcium mupirocin are used as topical antimicrobials for wounds in diabetics.

Aims and Objective: To evaluate effect of topical sodium fusidate, calcium mupirocin, and papain–urea on wound healing in diabetic wistar rats.

Materials and Methods: Incision and excision wound models were used. Each model had five groups of six rats each and one group was nondiabetic control. Diabetes was induced in the remaining four groups, one diabetic control, and three test groups in each model, using streptozotocin (30 mg/kg intraperitoneally). Wounds were made in diabetic rats with blood glucose levels of more than 250 mg/dL. Paraffin ointment base was applied to wounds of nondiabetic and diabetic control, whereas sodium fusidate, mupirocin, and papain–urea were applied topically to three test groups, respectively, in each model.

Result: In sodium fusidate-treated group, there was a significant increase in breaking strength of incision wound, contraction rate, and hydroxyproline content of excision wound as compared to diabetic control group. There was significant decrease in period of epithelization in sodium fusidate-treated group compared to diabetic control group. There was no significant alteration in wound healing by mupirocin and papain–urea.

Conclusion: Topical application of sodium fusidate promoted wound healing in diabetic rats.

Key words: Breaking strength; Epithelization; Wound contraction; Streptozotocin


 
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How to Cite this Article
Pubmed Style

Shenoy S, Murthy R, Mohan L, Gowda A, Nelluri VM. Effect of topical sodium fusidate, calcium mupirocin and papain—urea on wound healing in diabetic wistar rats. Natl J Physiol Pharm Pharmacol. 2016; 6(3): 209-214. doi:10.5455/njppp.2016.6.28012016115


Web Style

Shenoy S, Murthy R, Mohan L, Gowda A, Nelluri VM. Effect of topical sodium fusidate, calcium mupirocin and papain—urea on wound healing in diabetic wistar rats. https://www.njppp.com/?mno=216631 [Access: June 01, 2025]. doi:10.5455/njppp.2016.6.28012016115


AMA (American Medical Association) Style

Shenoy S, Murthy R, Mohan L, Gowda A, Nelluri VM. Effect of topical sodium fusidate, calcium mupirocin and papain—urea on wound healing in diabetic wistar rats. Natl J Physiol Pharm Pharmacol. 2016; 6(3): 209-214. doi:10.5455/njppp.2016.6.28012016115



Vancouver/ICMJE Style

Shenoy S, Murthy R, Mohan L, Gowda A, Nelluri VM. Effect of topical sodium fusidate, calcium mupirocin and papain—urea on wound healing in diabetic wistar rats. Natl J Physiol Pharm Pharmacol. (2016), [cited June 01, 2025]; 6(3): 209-214. doi:10.5455/njppp.2016.6.28012016115



Harvard Style

Shenoy, S., Murthy, . R., Mohan, . L., Gowda, . A. & Nelluri, . V. M. (2016) Effect of topical sodium fusidate, calcium mupirocin and papain—urea on wound healing in diabetic wistar rats. Natl J Physiol Pharm Pharmacol, 6 (3), 209-214. doi:10.5455/njppp.2016.6.28012016115



Turabian Style

Shenoy, Smita, Raghu Murthy, Lalit Mohan, Amoolya Gowda, and Venu Madhav Nelluri. 2016. Effect of topical sodium fusidate, calcium mupirocin and papain—urea on wound healing in diabetic wistar rats. National Journal of Physiology, Pharmacy and Pharmacology, 6 (3), 209-214. doi:10.5455/njppp.2016.6.28012016115



Chicago Style

Shenoy, Smita, Raghu Murthy, Lalit Mohan, Amoolya Gowda, and Venu Madhav Nelluri. "Effect of topical sodium fusidate, calcium mupirocin and papain—urea on wound healing in diabetic wistar rats." National Journal of Physiology, Pharmacy and Pharmacology 6 (2016), 209-214. doi:10.5455/njppp.2016.6.28012016115



MLA (The Modern Language Association) Style

Shenoy, Smita, Raghu Murthy, Lalit Mohan, Amoolya Gowda, and Venu Madhav Nelluri. "Effect of topical sodium fusidate, calcium mupirocin and papain—urea on wound healing in diabetic wistar rats." National Journal of Physiology, Pharmacy and Pharmacology 6.3 (2016), 209-214. Print. doi:10.5455/njppp.2016.6.28012016115



APA (American Psychological Association) Style

Shenoy, S., Murthy, . R., Mohan, . L., Gowda, . A. & Nelluri, . V. M. (2016) Effect of topical sodium fusidate, calcium mupirocin and papain—urea on wound healing in diabetic wistar rats. National Journal of Physiology, Pharmacy and Pharmacology, 6 (3), 209-214. doi:10.5455/njppp.2016.6.28012016115