E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research

Online Publishing Date:
16 / 05 / 2023

 


Third trimester HbA1c as a prognostic indicator in the prediction of large-for-gestational age babies in South Indian women with gestational diabetes mellitus: A cross-sectional study

Niveditha Pari, Viji Devanand, Sampathkumari S, Vasantha Kumar M, Valarmathi S.


Abstract
Background: The prevalence of hyperglycemia first detected during pregnancy is showing an escalating increase in recent years contributed by the increasing obesity prevalence, advanced maternal age at delivery, and the universal screening protocol during the first antenatal visit. There exists a very little data on the role of HbA1c in pregnancy and the results remain inconsistent. There is a need to define diagnostic criteria to predict the adverse perinatal outcomes in gestational diabetes mellitus (GDM).

Aims and Objectives: This study was aimed to assess the role of HbA1c as a prognostic indicator of third trimester mean blood glucose in GDM pregnancies and in predicting the birth of large for gestational age (LGA) babies.

Materials and Methods: 200 pregnant women with GDM and 200 pregnant women without GDM and their neonates participated in this analytical cross-sectional study. Maternal age, height, weight, BMI, and neonatal birth weight were recorded. Third trimester maternal HbA1c level was analyzed by high-performance liquid chromatography. The association between HbA1c and LGA births was analyzed.

Results: The mean HbA1c levels and percentage of LGA births were high in GDM group. Multiple logistic regression analysis showed association between high HbA1c values and LGA births in GDM. A Receiver operating characteristic curve was drawn to derive the optimal cut-off value, sensitivity, and specificity of HbA1c in predicting birth of LGA neonates in GDM.

Conclusion: This study shows that high third trimester HbA1c levels in GDM increase the risk of LGA births. Further studies are needed to define standard cut-off values of glycated Hb in each trimester of pregnancy.

Key words: Gestational Diabetes Mellitus; Glycated Hemoglobin; HbA1c; Large for Gestational Age; Macrosomia


 
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How to Cite this Article
Pubmed Style

Pari N, Devanand V, S S, M VK, S V. Third trimester HbA1c as a prognostic indicator in the prediction of large-for-gestational age babies in South Indian women with gestational diabetes mellitus: A cross-sectional study. Natl J Physiol Pharm Pharmacol. 2023; 13(6): 1308-1312. doi:10.5455/njppp.2023.13.04231202303052023


Web Style

Pari N, Devanand V, S S, M VK, S V. Third trimester HbA1c as a prognostic indicator in the prediction of large-for-gestational age babies in South Indian women with gestational diabetes mellitus: A cross-sectional study. https://www.njppp.com/?mno=151577 [Access: March 14, 2024]. doi:10.5455/njppp.2023.13.04231202303052023


AMA (American Medical Association) Style

Pari N, Devanand V, S S, M VK, S V. Third trimester HbA1c as a prognostic indicator in the prediction of large-for-gestational age babies in South Indian women with gestational diabetes mellitus: A cross-sectional study. Natl J Physiol Pharm Pharmacol. 2023; 13(6): 1308-1312. doi:10.5455/njppp.2023.13.04231202303052023



Vancouver/ICMJE Style

Pari N, Devanand V, S S, M VK, S V. Third trimester HbA1c as a prognostic indicator in the prediction of large-for-gestational age babies in South Indian women with gestational diabetes mellitus: A cross-sectional study. Natl J Physiol Pharm Pharmacol. (2023), [cited March 14, 2024]; 13(6): 1308-1312. doi:10.5455/njppp.2023.13.04231202303052023



Harvard Style

Pari, N., Devanand, . V., S, . S., M, . V. K. & S, . V. (2023) Third trimester HbA1c as a prognostic indicator in the prediction of large-for-gestational age babies in South Indian women with gestational diabetes mellitus: A cross-sectional study. Natl J Physiol Pharm Pharmacol, 13 (6), 1308-1312. doi:10.5455/njppp.2023.13.04231202303052023



Turabian Style

Pari, Niveditha, Viji Devanand, Sampathkumari S, Vasantha Kumar M, and Valarmathi S. 2023. Third trimester HbA1c as a prognostic indicator in the prediction of large-for-gestational age babies in South Indian women with gestational diabetes mellitus: A cross-sectional study. National Journal of Physiology, Pharmacy and Pharmacology, 13 (6), 1308-1312. doi:10.5455/njppp.2023.13.04231202303052023



Chicago Style

Pari, Niveditha, Viji Devanand, Sampathkumari S, Vasantha Kumar M, and Valarmathi S. "Third trimester HbA1c as a prognostic indicator in the prediction of large-for-gestational age babies in South Indian women with gestational diabetes mellitus: A cross-sectional study." National Journal of Physiology, Pharmacy and Pharmacology 13 (2023), 1308-1312. doi:10.5455/njppp.2023.13.04231202303052023



MLA (The Modern Language Association) Style

Pari, Niveditha, Viji Devanand, Sampathkumari S, Vasantha Kumar M, and Valarmathi S. "Third trimester HbA1c as a prognostic indicator in the prediction of large-for-gestational age babies in South Indian women with gestational diabetes mellitus: A cross-sectional study." National Journal of Physiology, Pharmacy and Pharmacology 13.6 (2023), 1308-1312. Print. doi:10.5455/njppp.2023.13.04231202303052023



APA (American Psychological Association) Style

Pari, N., Devanand, . V., S, . S., M, . V. K. & S, . V. (2023) Third trimester HbA1c as a prognostic indicator in the prediction of large-for-gestational age babies in South Indian women with gestational diabetes mellitus: A cross-sectional study. National Journal of Physiology, Pharmacy and Pharmacology, 13 (6), 1308-1312. doi:10.5455/njppp.2023.13.04231202303052023