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Original Research

Online Publishing Date:
12 / 11 / 2021

 


Association of serum uric acid with waist-hip ratio: A promising index for assessing cardiovascular disease risk profile

Ankita Chaturvedi, Arvind Kumar Pal, Khushboo Singhal, Narsingh Verma.


Abstract
Background: Abdominal obesity is associated with insulin resistance, in turn, hyperinsulinemia and visceral adiposity lead to an increased uric acid (UA) absorption in renal tubules.

Aim and Objectives: Accumulation of visceral fat is an underlying component of metabolic syndrome. Furthermore, the waist-hip ratio is an indirect tool for assessing visceral fat. The present study evaluates the association of UA levels with the waist-hip ratio.

Materials and Methods: 160 subjects aged 18–60 years were enrolled in the study (those having any anatomical deformity, diabetes, and/or hypertension for more than 5 years were excluded from the study). Their anthropometric parameters, blood pressure, lipid profile, fasting plasma glucose, and serum UA levels were measured.

Results: The study population was divided into three groups based on UA levels. The waist-hip ratio in a group of the hyperuricemic population was more as compared to groups of normal and below normal UA levels population and the association of UA level with waist-hip ratio was found to be significant (P = 0.045).

Conclusion: The over-inflow of free fatty acid to the liver from accumulated visceral fat may be linked to the de novo purine synthesis through the pentose phosphate pathway, which may accelerate the production of UA.

Key words: Waist-hip Ratio; Serum Uric Acid; Visceral Fat


 
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How to Cite this Article
Pubmed Style

Chaturvedi A, Pal AK, Singhal K, Verma N. Association of serum uric acid with waist-hip ratio: A promising index for assessing cardiovascular disease risk profile. Natl J Physiol Pharm Pharmacol. 2022; 12(5): 629-631. doi:10.5455/njppp.2022.12.10386202102112021

Web Style

Chaturvedi A, Pal AK, Singhal K, Verma N. Association of serum uric acid with waist-hip ratio: A promising index for assessing cardiovascular disease risk profile. https://www.njppp.com/?mno=135332 [Access: March 14, 2024]. doi:10.5455/njppp.2022.12.10386202102112021

AMA (American Medical Association) Style

Chaturvedi A, Pal AK, Singhal K, Verma N. Association of serum uric acid with waist-hip ratio: A promising index for assessing cardiovascular disease risk profile. Natl J Physiol Pharm Pharmacol. 2022; 12(5): 629-631. doi:10.5455/njppp.2022.12.10386202102112021


Vancouver/ICMJE Style

Chaturvedi A, Pal AK, Singhal K, Verma N. Association of serum uric acid with waist-hip ratio: A promising index for assessing cardiovascular disease risk profile. Natl J Physiol Pharm Pharmacol. (2022), [cited March 14, 2024]; 12(5): 629-631. doi:10.5455/njppp.2022.12.10386202102112021


Harvard Style

Chaturvedi, A., Pal, . A. K., Singhal, . K. & Verma, . N. (2022) Association of serum uric acid with waist-hip ratio: A promising index for assessing cardiovascular disease risk profile. Natl J Physiol Pharm Pharmacol, 12 (5), 629-631. doi:10.5455/njppp.2022.12.10386202102112021


Turabian Style

Chaturvedi, Ankita, Arvind Kumar Pal, Khushboo Singhal, and Narsingh Verma. 2022. Association of serum uric acid with waist-hip ratio: A promising index for assessing cardiovascular disease risk profile. National Journal of Physiology, Pharmacy and Pharmacology, 12 (5), 629-631. doi:10.5455/njppp.2022.12.10386202102112021


Chicago Style

Chaturvedi, Ankita, Arvind Kumar Pal, Khushboo Singhal, and Narsingh Verma. "Association of serum uric acid with waist-hip ratio: A promising index for assessing cardiovascular disease risk profile." National Journal of Physiology, Pharmacy and Pharmacology 12 (2022), 629-631. doi:10.5455/njppp.2022.12.10386202102112021


MLA (The Modern Language Association) Style

Chaturvedi, Ankita, Arvind Kumar Pal, Khushboo Singhal, and Narsingh Verma. "Association of serum uric acid with waist-hip ratio: A promising index for assessing cardiovascular disease risk profile." National Journal of Physiology, Pharmacy and Pharmacology 12.5 (2022), 629-631. Print. doi:10.5455/njppp.2022.12.10386202102112021


APA (American Psychological Association) Style

Chaturvedi, A., Pal, . A. K., Singhal, . K. & Verma, . N. (2022) Association of serum uric acid with waist-hip ratio: A promising index for assessing cardiovascular disease risk profile. National Journal of Physiology, Pharmacy and Pharmacology, 12 (5), 629-631. doi:10.5455/njppp.2022.12.10386202102112021


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