Adverse drug reaction profile of patients taking amantadine for traumatic brain injury in a tertiary care hospital

Firoz Thaha; Satheesh Chandra Sugatha Rao; Lima Koruthara Mohanan; Preetha Jose

doi:10.5455/njppp.2023.13.11551202204122022

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Online Published: 13 Dec 2022

Natl J Physiol Pharm Pharmacol. 2023; 13(1): 172-176

doi: 10.5455/njppp.2023.13.11551202204122022

Adverse drug reaction profile of patients taking amantadine for traumatic brain injury in a tertiary care hospital

Firoz Thaha, Satheesh Chandra Sugatha Rao, Lima Koruthara Mohanan, Preetha Jose.

Abstract
Background: Amantadine is found to be effective for the treatment of complications associated with traumatic brain injury. Drug-related side effects are common with Amantadine especially when combined with other drugs. Comprehensive information about the incidence and severity of these adverse effects is not available.

Aim and Objectives: The aim of the study was to analyze the pattern of occurrence of adverse drug reactions (ADRs) in patients receiving Amantadine for traumatic brain injury in a tertiary care hospital. We also assessed the causality, severity and preventability of ADRs.

Materials and Methods: This prospective cohort study was conducted among patients taking Amantadine for a continuous period of 1 month for traumatic brain injury in neurosurgery department between June 2020 and December 2020. Tools used were ADR Reporting form of National Pharmacovigilance Centre, WHO causality scale, Hartwig and Siegel scale, and Schumock and Thornton scale. Descriptive statistics were used and the values were expressed in numbers and percentages.

Results: ADRs were experienced in 55 patients (36.7%) out of 150 patients and all the patients were on combination therapy. ADR was present more in male patients (63.6%) compared to females (36.4%). The most common ADRs were headache, ankle edema and dry mouth. Majority of ADRs belonged to the possible category according to the WHO causality assessment scale. Majority of the ADRs (61.9%) were mild level 1 according to severity scale. All the ADRs came under the definitely or probably preventable category.

Conclusion: ADRs with Amantadine are common but mild and preventable.

Key words: Amantadine; Adverse Drug Event; Traumatic Brain Injury

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How to Cite this Article

Pubmed Style

Thaha F, Rao SCS, Mohanan LK, Jose P. Adverse drug reaction profile of patients taking amantadine for traumatic brain injury in a tertiary care hospital. Natl J Physiol Pharm Pharmacol. 2023; 13(1): 172-176.

doi:10.5455/njppp.2023.13.11551202204122022

Web Style

Thaha F, Rao SCS, Mohanan LK, Jose P. Adverse drug reaction profile of patients taking amantadine for traumatic brain injury in a tertiary care hospital. https://www.njppp.com/?mno=130069 [Access: June 27, 2026].

doi:10.5455/njppp.2023.13.11551202204122022

AMA (American Medical Association) Style

Thaha F, Rao SCS, Mohanan LK, Jose P. Adverse drug reaction profile of patients taking amantadine for traumatic brain injury in a tertiary care hospital. Natl J Physiol Pharm Pharmacol. 2023; 13(1): 172-176.

doi:10.5455/njppp.2023.13.11551202204122022

Vancouver/ICMJE Style

Thaha F, Rao SCS, Mohanan LK, Jose P. Adverse drug reaction profile of patients taking amantadine for traumatic brain injury in a tertiary care hospital. Natl J Physiol Pharm Pharmacol. (2023), [cited June 27, 2026]; 13(1): 172-176.

doi:10.5455/njppp.2023.13.11551202204122022

Harvard Style

Thaha, F., Rao, . S. C. S., Mohanan, . L. K. & Jose, . P. (2023) Adverse drug reaction profile of patients taking amantadine for traumatic brain injury in a tertiary care hospital. Natl J Physiol Pharm Pharmacol, 13 (1), 172-176.

doi:10.5455/njppp.2023.13.11551202204122022

Turabian Style

Thaha, Firoz, Satheesh Chandra Sugatha Rao, Lima Koruthara Mohanan, and Preetha Jose. 2023. Adverse drug reaction profile of patients taking amantadine for traumatic brain injury in a tertiary care hospital. National Journal of Physiology, Pharmacy and Pharmacology, 13 (1), 172-176.

doi:10.5455/njppp.2023.13.11551202204122022

Chicago Style

Thaha, Firoz, Satheesh Chandra Sugatha Rao, Lima Koruthara Mohanan, and Preetha Jose. "Adverse drug reaction profile of patients taking amantadine for traumatic brain injury in a tertiary care hospital." National Journal of Physiology, Pharmacy and Pharmacology 13 (2023), 172-176.

doi:10.5455/njppp.2023.13.11551202204122022

MLA (The Modern Language Association) Style

doi:10.5455/njppp.2023.13.11551202204122022

APA (American Psychological Association) Style

doi:10.5455/njppp.2023.13.11551202204122022

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