A cross-sectional study to estimate the serum level of C-reactive protein among pediatric meningitis with bacterial etiology

Jayita Dasgupta (Ghosh); Sambit Dasgupta; Jayashree Konar

doi:10.5455/njppp.2023.13.11527202216112022

2024, Vol: 14, Issue: 4

14 / 4Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Required files to be uploaded

Authorship Declaration

« Previous Article

Original Research

Online Publishing Date:
29 / 11 / 2022

Natl J Physiol Pharm Pharmacol. 2023; 13(6): 1205-1208

doi: 10.5455/njppp.2023.13.11527202216112022

A cross-sectional study to estimate the serum level of C-reactive protein among pediatric meningitis with bacterial etiology

Jayita Dasgupta (Ghosh), Sambit Dasgupta, Jayashree Konar.

Abstract
Background: Bacterial meningitis is a global public health issue. C-reactive protein (CRP) has suitable diagnostic value in distinguishing between bacterial and aseptic meningitis especially in cases of negative bacterial culture of the blood and spinal fluid.

Aim and Objective: The objective of this study was to estimate the serum level of CRP among pediatric meningitis cases with bacterial etiology.

Materials and Methods: The hospital-based descriptive cross-sectional study was performed in a tertiary care pediatric hospital in Eastern India from June to August, 2021 with 150 samples. Patients fulfilling the inclusion criteria were selected for this study after obtaining informed consent. Cerebrospinal fluid sample was collected as per standard guidelines. Phenotypic identification of bacteria including antimicrobial susceptibility testing was done by automation (Vitek 2 compact, bioMerieux). Quantitative estimation of CRP was performed in a solid phase and sandwich-format immunometric assay using a gold antibody conjugate. Human rights, welfare, and autonomy were protected as per national ethical guidelines.

Results: Median age (Inter Quartile Range) of 150 cases was 3(1–4.5) year. Escherichia coli (60.52%, 23/38) was the commonest isolate (P < 0.00000001 by Binomial test calculation) followed by Klebsiella pneumoniae (34.24%, i.e., 13/38). A total of 43/150 (28.66%) participants had higher serum CRP. Serum CRP was raised more in Gram-negative bacterial etiology (36 out of 38, 94.73%). Mean serum CRP was higher in Gram-negative cases (P < 0.05).

Conclusion: Serum CRP was found significantly higher in meningitis caused by Gram-negative bacteria.

Key words: C-Reactive Protein; Meningitis; Gram-Negative; Gram-Positive

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by Jayita Dasgupta (Ghosh) Articles by Sambit Dasgupta Articles by Jayashree Konar
	on Google
	on Google Scholar

How to Cite this Article

Pubmed Style

(Ghosh) JD, Dasgupta S, Konar J. A cross-sectional study to estimate the serum level of C-reactive protein among pediatric meningitis with bacterial etiology. Natl J Physiol Pharm Pharmacol. 2023; 13(6): 1205-1208. doi:10.5455/njppp.2023.13.11527202216112022

Web Style

(Ghosh) JD, Dasgupta S, Konar J. A cross-sectional study to estimate the serum level of C-reactive protein among pediatric meningitis with bacterial etiology. https://www.njppp.com/?mno=127931 [Access: March 15, 2024]. doi:10.5455/njppp.2023.13.11527202216112022

AMA (American Medical Association) Style

(Ghosh) JD, Dasgupta S, Konar J. A cross-sectional study to estimate the serum level of C-reactive protein among pediatric meningitis with bacterial etiology. Natl J Physiol Pharm Pharmacol. 2023; 13(6): 1205-1208. doi:10.5455/njppp.2023.13.11527202216112022

Vancouver/ICMJE Style

(Ghosh) JD, Dasgupta S, Konar J. A cross-sectional study to estimate the serum level of C-reactive protein among pediatric meningitis with bacterial etiology. Natl J Physiol Pharm Pharmacol. (2023), [cited March 15, 2024]; 13(6): 1205-1208. doi:10.5455/njppp.2023.13.11527202216112022

Harvard Style

(Ghosh), J. D., Dasgupta, . S. & Konar, . J. (2023) A cross-sectional study to estimate the serum level of C-reactive protein among pediatric meningitis with bacterial etiology. Natl J Physiol Pharm Pharmacol, 13 (6), 1205-1208. doi:10.5455/njppp.2023.13.11527202216112022

Turabian Style

(Ghosh), Jayita Dasgupta, Sambit Dasgupta, and Jayashree Konar. 2023. A cross-sectional study to estimate the serum level of C-reactive protein among pediatric meningitis with bacterial etiology. National Journal of Physiology, Pharmacy and Pharmacology, 13 (6), 1205-1208. doi:10.5455/njppp.2023.13.11527202216112022

Chicago Style

(Ghosh), Jayita Dasgupta, Sambit Dasgupta, and Jayashree Konar. "A cross-sectional study to estimate the serum level of C-reactive protein among pediatric meningitis with bacterial etiology." National Journal of Physiology, Pharmacy and Pharmacology 13 (2023), 1205-1208. doi:10.5455/njppp.2023.13.11527202216112022

MLA (The Modern Language Association) Style

(Ghosh), Jayita Dasgupta, Sambit Dasgupta, and Jayashree Konar. "A cross-sectional study to estimate the serum level of C-reactive protein among pediatric meningitis with bacterial etiology." National Journal of Physiology, Pharmacy and Pharmacology 13.6 (2023), 1205-1208. Print. doi:10.5455/njppp.2023.13.11527202216112022

APA (American Psychological Association) Style

(Ghosh), J. D., Dasgupta, . S. & Konar, . J. (2023) A cross-sectional study to estimate the serum level of C-reactive protein among pediatric meningitis with bacterial etiology. National Journal of Physiology, Pharmacy and Pharmacology, 13 (6), 1205-1208. doi:10.5455/njppp.2023.13.11527202216112022

Author Login Reviewer Login About Publisher Editorial Policies Editorial Review Policy Peer Review Policy Editorial & Peer Review Process Publication Ethics and Publication Malpractice Statement Conflict of Interest Policy Plagiarism Policy Protection of Research Participants (Statement On Human And Animal Rights)Corrections, Retractions & Expressions of Concern Self-Archiving Policies Statement of Informed Consent Advertising Policy Terms of Use License Information Copyright Information

About National Journal of Physiology, Pharmacy and Pharmacology

Contact Information

How to cite this article


About National Journal of Physiology, Pharmacy and Pharmacology National Journal of Physiology, Pharmacy and Pharmacology is a monthly peer reviewed journal. The journal is having open access polic ... Read more. For best results, please use Internet Explorer or Google Chrome.	Contact Information Publisher publishernjppp@gmail.com Editorial query editornjppp1@gmail.com MOB - 8780040272