A comparative study of cardiac autonomic function tests in hypothyroid patients and euthyroid subjects

Rajesh Kumar Paul; Subodh Pandey; Sachin Chittawar; Kirtika Shrivastav

doi:10.5455/njppp.2021.10.08223202026082020

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Online Published: 08 Sep 2020

Natl J Physiol Pharm Pharmacol. 2021; 11(1): 37-40

doi: 10.5455/njppp.2021.10.08223202026082020

A comparative study of cardiac autonomic function tests in hypothyroid patients and euthyroid subjects

Rajesh Kumar Paul, Subodh Pandey, Sachin Chittawar, Kirtika Shrivastav.

Cited By:1

Abstract
Background: Thyroid hormone has very deep effects on the heart and can cause sympathovagal imbalance. Sympathovagal imbalance can lead to cardiac autonomic neuropathy (CAN) in hypothyroid patients.

Aims and objectives: The study aimed to assess the CAN in hypothyroidism and compare CAN in hypothyroid patients and euthyroid subjects.

Materials and Methods: Fifty hypothyroid patients and 50 euthyroid subjects were selected for the study after satisfying the inclusion and exclusion criteria. Autonomic function tests were performed as per Ewings and Clarke criterion including three parasympathetic (deep breathing test, 30:15 ratio, and Valsalva ratio [VR]) and two (sustained handgrip and postural hypotension test) sympathetic tests.

Results: On comparing the mean of the test between euthyroid and hypothyroid patient, VR in parasympathetic and both sympathetic tests were statistically significant.

Conclusion: There is an increased prevalence of CAN in hypothyroidism in comparison to the controls.

Key words: Cardiac Autonomic Neuropathy; Deep Breathing Test; Valsalva Ratio; Sustained Handgrip; Postural Hypotension Test

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Pubmed Style

Paul RK, Pandey S, Chittawar S, Shrivastav K. A comparative study of cardiac autonomic function tests in hypothyroid patients and euthyroid subjects. Natl J Physiol Pharm Pharmacol. 2021; 11(1): 37-40.

doi:10.5455/njppp.2021.10.08223202026082020

Web Style

Paul RK, Pandey S, Chittawar S, Shrivastav K. A comparative study of cardiac autonomic function tests in hypothyroid patients and euthyroid subjects. https://www.njppp.com/?mno=125891 [Access: June 26, 2026].

doi:10.5455/njppp.2021.10.08223202026082020

AMA (American Medical Association) Style

Paul RK, Pandey S, Chittawar S, Shrivastav K. A comparative study of cardiac autonomic function tests in hypothyroid patients and euthyroid subjects. Natl J Physiol Pharm Pharmacol. 2021; 11(1): 37-40.

doi:10.5455/njppp.2021.10.08223202026082020

Vancouver/ICMJE Style

Paul RK, Pandey S, Chittawar S, Shrivastav K. A comparative study of cardiac autonomic function tests in hypothyroid patients and euthyroid subjects. Natl J Physiol Pharm Pharmacol. (2021), [cited June 26, 2026]; 11(1): 37-40.

doi:10.5455/njppp.2021.10.08223202026082020

Harvard Style

Paul, R. K., Pandey, . S., Chittawar, . S. & Shrivastav, . K. (2021) A comparative study of cardiac autonomic function tests in hypothyroid patients and euthyroid subjects. Natl J Physiol Pharm Pharmacol, 11 (1), 37-40.

doi:10.5455/njppp.2021.10.08223202026082020

Turabian Style

Paul, Rajesh Kumar, Subodh Pandey, Sachin Chittawar, and Kirtika Shrivastav. 2021. A comparative study of cardiac autonomic function tests in hypothyroid patients and euthyroid subjects. National Journal of Physiology, Pharmacy and Pharmacology, 11 (1), 37-40.

doi:10.5455/njppp.2021.10.08223202026082020

Chicago Style

Paul, Rajesh Kumar, Subodh Pandey, Sachin Chittawar, and Kirtika Shrivastav. "A comparative study of cardiac autonomic function tests in hypothyroid patients and euthyroid subjects." National Journal of Physiology, Pharmacy and Pharmacology 11 (2021), 37-40.

doi:10.5455/njppp.2021.10.08223202026082020

MLA (The Modern Language Association) Style

doi:10.5455/njppp.2021.10.08223202026082020

APA (American Psychological Association) Style

Paul, R. K., Pandey, . S., Chittawar, . S. & Shrivastav, . K. (2021) A comparative study of cardiac autonomic function tests in hypothyroid patients and euthyroid subjects. National Journal of Physiology, Pharmacy and Pharmacology, 11 (1), 37-40.

doi:10.5455/njppp.2021.10.08223202026082020

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