Correlation of oxidative stress and serum gonadotropins in female infertility - A cross sectional study in a tertiary care hospital in Eastern Zone of India

Partha Mandal; Phalguni Chakrabarti; Debasmita Bandyopadhyay; Koushik Mondal

doi:10.5455/njppp.2022.12.09336202106102021

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20 / 10 / 2021

Natl J Physiol Pharm Pharmacol. 2022; 12(4): 456-461

doi: 10.5455/njppp.2022.12.09336202106102021

Correlation of oxidative stress and serum gonadotropins in female infertility - A cross sectional study in a tertiary care hospital in Eastern Zone of India

Partha Mandal, Phalguni Chakrabarti, Debasmita Bandyopadhyay, Koushik Mondal.

Abstract
Background: Infertility is a very important issue to family and society. Oxidative stress (OS) may affect ovulation, fertilization, embryo development, and implantation resulting in infertility in women. Gonadotropins are required for follicle development and estrogen production, hence low levels of these hormones may result infertility.

Aim and Objectives: Our aim was to study OS and serum gonadotropins level in infertile women and to study whether the OS has any effect on gonadotropins level in infertile women.

Materials and Methods: It is a hospital-based cross-sectional study. The study group included 50 infertile women in the age of 2045 years. Age-matched 50 women without a history of infertility were selected as control. Serum samples were collected on the third day of the menstrual cycle and assayed for carbonylation of serum protein, a marker of OS by Levines method and Serum Follicle-stimulating hormone and luteinizing hormone by Chemiluminescence Immunoassay method in ADVIA, Centaur CP (SIEMENS) autoanalyzer. Statistical analysis of data was done by SPSS software. P < 0.05 was considered statistically significant.

Results: From our study, we observed that OS was significantly high in infertile women than control (P < 0.05). Serum gonadotropins levels were significantly low in infertile women than control (P < 0.05). Our study shows significant negative correlations between OS and serum gonadotropins level in infertile women (P < 0.001).

Conclusion: It can be concluded that both OS and low serum gonadotropin levels may be etiological factors for infertility in women. Oxidative can cause infertility by direct effect on reproduction physiology as well as by lowering gonadotropin level. So OS and serum gonadotropin levels can be emphasized in case of treatment of female infertility.

Key words: Infertility; Oxidative Stress, Reactive Oxygen Species, Gonadotropin

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How to Cite this Article

Pubmed Style

Mandal P, Chakrabarti P, Bandyopadhyay D, Mondal K. Correlation of oxidative stress and serum gonadotropins in female infertility - A cross sectional study in a tertiary care hospital in Eastern Zone of India. Natl J Physiol Pharm Pharmacol. 2022; 12(4): 456-461. doi:10.5455/njppp.2022.12.09336202106102021

Web Style

Mandal P, Chakrabarti P, Bandyopadhyay D, Mondal K. Correlation of oxidative stress and serum gonadotropins in female infertility - A cross sectional study in a tertiary care hospital in Eastern Zone of India. https://www.njppp.com/?mno=125149 [Access: March 14, 2024]. doi:10.5455/njppp.2022.12.09336202106102021

AMA (American Medical Association) Style

Mandal P, Chakrabarti P, Bandyopadhyay D, Mondal K. Correlation of oxidative stress and serum gonadotropins in female infertility - A cross sectional study in a tertiary care hospital in Eastern Zone of India. Natl J Physiol Pharm Pharmacol. 2022; 12(4): 456-461. doi:10.5455/njppp.2022.12.09336202106102021

Vancouver/ICMJE Style

Mandal P, Chakrabarti P, Bandyopadhyay D, Mondal K. Correlation of oxidative stress and serum gonadotropins in female infertility - A cross sectional study in a tertiary care hospital in Eastern Zone of India. Natl J Physiol Pharm Pharmacol. (2022), [cited March 14, 2024]; 12(4): 456-461. doi:10.5455/njppp.2022.12.09336202106102021

Harvard Style

Mandal, P., Chakrabarti, . P., Bandyopadhyay, . D. & Mondal, . K. (2022) Correlation of oxidative stress and serum gonadotropins in female infertility - A cross sectional study in a tertiary care hospital in Eastern Zone of India. Natl J Physiol Pharm Pharmacol, 12 (4), 456-461. doi:10.5455/njppp.2022.12.09336202106102021

Turabian Style

Mandal, Partha, Phalguni Chakrabarti, Debasmita Bandyopadhyay, and Koushik Mondal. 2022. Correlation of oxidative stress and serum gonadotropins in female infertility - A cross sectional study in a tertiary care hospital in Eastern Zone of India. National Journal of Physiology, Pharmacy and Pharmacology, 12 (4), 456-461. doi:10.5455/njppp.2022.12.09336202106102021

Chicago Style

Mandal, Partha, Phalguni Chakrabarti, Debasmita Bandyopadhyay, and Koushik Mondal. "Correlation of oxidative stress and serum gonadotropins in female infertility - A cross sectional study in a tertiary care hospital in Eastern Zone of India." National Journal of Physiology, Pharmacy and Pharmacology 12 (2022), 456-461. doi:10.5455/njppp.2022.12.09336202106102021

MLA (The Modern Language Association) Style

Mandal, Partha, Phalguni Chakrabarti, Debasmita Bandyopadhyay, and Koushik Mondal. "Correlation of oxidative stress and serum gonadotropins in female infertility - A cross sectional study in a tertiary care hospital in Eastern Zone of India." National Journal of Physiology, Pharmacy and Pharmacology 12.4 (2022), 456-461. Print. doi:10.5455/njppp.2022.12.09336202106102021

APA (American Psychological Association) Style

Mandal, P., Chakrabarti, . P., Bandyopadhyay, . D. & Mondal, . K. (2022) Correlation of oxidative stress and serum gonadotropins in female infertility - A cross sectional study in a tertiary care hospital in Eastern Zone of India. National Journal of Physiology, Pharmacy and Pharmacology, 12 (4), 456-461. doi:10.5455/njppp.2022.12.09336202106102021

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