E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Comparison of efficacy of Gabapentin versus Pregabalin in patients of painful diabetic peripheral neuropathy – A randomized, open label, and parallel group study

Arvinth A, Suganya E.

Abstract
Background: Diabetes is a form of chronic illness requiring a collective treatment approach such as glycemic monitoring, self-management, education, and adequate support to prevent the occurrence of acute complications. One of the most frequently occurring complication in Type 2 diabetes has been diabetic peripheral neuropathy (DPN) or distal symmetrical polyneuropathy. Newer anticonvulsants such as Gabapentin and Pregabalin have been proven beneficial in patients with peripheral neuropathic pain.

Aims and Objectives: The aim of the study was to compare the efficacy of Gabapentin and Pregabalin in relieving the pain in patients of DPN.

Materials and Methods: This is an open label, randomized, multi-dose, two treatment, single-period, single-center, parallel study comparing Gabapentin and Pregabalin for efficacy in patients suffering with DPN using visual analog scale, daily sleep interference score, patient’s global impression of change, and clinician’s global impression of change.

Results: One hundred patients were randomized into two groups and the treatment started as and when they reported to the hospital. Statistical analysis was done in SPSS version 23 and intent to treat principle is employed for analysis. Results were distributed in demographics and treatment comparison. Decreased sleep interference and global impression of change reported during first visit, in which participants under Pregabalin group had better improvement score comparing Gabapentin group alone was found statistically significant (P < 0.05).

Conclusion: Our study revealed that Pregabalin is found to be more efficacious when compared to Gabapentin among Type 2 diabetes mellitus patients with painful peripheral neuropathy. Hence, we conclude that Pregabalin provided significant improvement in pain relief and other perspectives.

Key words: Gabapentin; Pregabalin; Diabetic Peripheral Neuropathy; Visual Analog Scale; Daily Sleep Interference Score; Global Impression of Change


 
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Pubmed Style

A A, E S. Comparison of efficacy of Gabapentin versus Pregabalin in patients of painful diabetic peripheral neuropathy – A randomized, open label, and parallel group study. Natl J Physiol Pharm Pharmacol. 2022; 12(11): 1901-1906. doi:10.5455/njppp.2022.12.03111202219032


Web Style

A A, E S. Comparison of efficacy of Gabapentin versus Pregabalin in patients of painful diabetic peripheral neuropathy – A randomized, open label, and parallel group study. https://www.njppp.com/?mno=99443 [Access: November 24, 2022]. doi:10.5455/njppp.2022.12.03111202219032


AMA (American Medical Association) Style

A A, E S. Comparison of efficacy of Gabapentin versus Pregabalin in patients of painful diabetic peripheral neuropathy – A randomized, open label, and parallel group study. Natl J Physiol Pharm Pharmacol. 2022; 12(11): 1901-1906. doi:10.5455/njppp.2022.12.03111202219032



Vancouver/ICMJE Style

A A, E S. Comparison of efficacy of Gabapentin versus Pregabalin in patients of painful diabetic peripheral neuropathy – A randomized, open label, and parallel group study. Natl J Physiol Pharm Pharmacol. (2022), [cited November 24, 2022]; 12(11): 1901-1906. doi:10.5455/njppp.2022.12.03111202219032



Harvard Style

A, A. & E, . S. (2022) Comparison of efficacy of Gabapentin versus Pregabalin in patients of painful diabetic peripheral neuropathy – A randomized, open label, and parallel group study. Natl J Physiol Pharm Pharmacol, 12 (11), 1901-1906. doi:10.5455/njppp.2022.12.03111202219032



Turabian Style

A, Arvinth, and Suganya E. 2022. Comparison of efficacy of Gabapentin versus Pregabalin in patients of painful diabetic peripheral neuropathy – A randomized, open label, and parallel group study. National Journal of Physiology, Pharmacy and Pharmacology, 12 (11), 1901-1906. doi:10.5455/njppp.2022.12.03111202219032



Chicago Style

A, Arvinth, and Suganya E. "Comparison of efficacy of Gabapentin versus Pregabalin in patients of painful diabetic peripheral neuropathy – A randomized, open label, and parallel group study." National Journal of Physiology, Pharmacy and Pharmacology 12 (2022), 1901-1906. doi:10.5455/njppp.2022.12.03111202219032



MLA (The Modern Language Association) Style

A, Arvinth, and Suganya E. "Comparison of efficacy of Gabapentin versus Pregabalin in patients of painful diabetic peripheral neuropathy – A randomized, open label, and parallel group study." National Journal of Physiology, Pharmacy and Pharmacology 12.11 (2022), 1901-1906. Print. doi:10.5455/njppp.2022.12.03111202219032



APA (American Psychological Association) Style

A, A. & E, . S. (2022) Comparison of efficacy of Gabapentin versus Pregabalin in patients of painful diabetic peripheral neuropathy – A randomized, open label, and parallel group study. National Journal of Physiology, Pharmacy and Pharmacology, 12 (11), 1901-1906. doi:10.5455/njppp.2022.12.03111202219032