E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Comparative CNS activities of chlorpheniramine maleate, ebastine, and fexofenadine in Swiss albino mice

Sugirda P, Henry Daniel Raj T, Divakar R.

Abstract
Background: Not all second-generation antihistamines were devoid of the central nervous system (CNS) effects such as cognitive and psychomotor impairment. Although these drugs penetrate blood–brain barrier (BBB) to lesser extent, many of them have been found to produce dose-related impairment of CNS functions with interdrug differences present among them.

Aim and Objective: This study is aimed to analyze and compare the effects of different antihistamines (first and second generation) on the CNS using Swiss albino mice.

Materials and Methods: Twenty-four Swiss albino mice of either sex weighing around 25 - 30 g were randomly divided into six groups with six in each group. Antihistamines such as chlorpheniramine maleate (CPM), ebastine, and fexofenadine were administered to respective groups through oral route. Their effects on CNS were evaluated using rotarod and actophotometer. The data were analyzed using statistical methods.

Results: CPM produced significant reduction (P < 0.05) in motor coordination and spontaneous locomotor activity. Ebastine does not have any effect on motor coordination but significant reduction (P < 0.05) in spontaneous locomotor activity. Fexofenadine does not have any effect on motor coordination and spontaneous locomotor activity.

Conclusion: We conclude that CPM has significant CNS depressant actions, ebastine has minimal CNS depressant actions, and fexofenadine does not have CNS depressant actions.

Key words: Antihistamines; Central Nervous System; Spontaneous Locomotor Activity; Motor Coordination


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Sugirda P
Articles by Henry Daniel Raj T
Articles by Divakar R
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

P S, T HDR, R D. Comparative CNS activities of chlorpheniramine maleate, ebastine, and fexofenadine in Swiss albino mice. Natl J Physiol Pharm Pharmacol. 2022; 12(5): 657-661. doi:10.5455/njppp.2022.12.0310920220002042022


Web Style

P S, T HDR, R D. Comparative CNS activities of chlorpheniramine maleate, ebastine, and fexofenadine in Swiss albino mice. https://www.njppp.com/?mno=99249 [Access: May 02, 2022]. doi:10.5455/njppp.2022.12.0310920220002042022


AMA (American Medical Association) Style

P S, T HDR, R D. Comparative CNS activities of chlorpheniramine maleate, ebastine, and fexofenadine in Swiss albino mice. Natl J Physiol Pharm Pharmacol. 2022; 12(5): 657-661. doi:10.5455/njppp.2022.12.0310920220002042022



Vancouver/ICMJE Style

P S, T HDR, R D. Comparative CNS activities of chlorpheniramine maleate, ebastine, and fexofenadine in Swiss albino mice. Natl J Physiol Pharm Pharmacol. (2022), [cited May 02, 2022]; 12(5): 657-661. doi:10.5455/njppp.2022.12.0310920220002042022



Harvard Style

P, S., T, . H. D. R. & R, . D. (2022) Comparative CNS activities of chlorpheniramine maleate, ebastine, and fexofenadine in Swiss albino mice. Natl J Physiol Pharm Pharmacol, 12 (5), 657-661. doi:10.5455/njppp.2022.12.0310920220002042022



Turabian Style

P, Sugirda, Henry Daniel Raj T, and Divakar R. 2022. Comparative CNS activities of chlorpheniramine maleate, ebastine, and fexofenadine in Swiss albino mice. National Journal of Physiology, Pharmacy and Pharmacology, 12 (5), 657-661. doi:10.5455/njppp.2022.12.0310920220002042022



Chicago Style

P, Sugirda, Henry Daniel Raj T, and Divakar R. "Comparative CNS activities of chlorpheniramine maleate, ebastine, and fexofenadine in Swiss albino mice." National Journal of Physiology, Pharmacy and Pharmacology 12 (2022), 657-661. doi:10.5455/njppp.2022.12.0310920220002042022



MLA (The Modern Language Association) Style

P, Sugirda, Henry Daniel Raj T, and Divakar R. "Comparative CNS activities of chlorpheniramine maleate, ebastine, and fexofenadine in Swiss albino mice." National Journal of Physiology, Pharmacy and Pharmacology 12.5 (2022), 657-661. Print. doi:10.5455/njppp.2022.12.0310920220002042022



APA (American Psychological Association) Style

P, S., T, . H. D. R. & R, . D. (2022) Comparative CNS activities of chlorpheniramine maleate, ebastine, and fexofenadine in Swiss albino mice. National Journal of Physiology, Pharmacy and Pharmacology, 12 (5), 657-661. doi:10.5455/njppp.2022.12.0310920220002042022