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Histopathological changes in the uterus in women with abnormal uterine bleeding – A 2-year hospital-based retrospective study in a tertiary care center in Assam, India

Akash Pradeep Bhuyan, Partha Pratim Talukdar, Amrit Sarmah.

Abstract
Background: Abnormal uterine bleeding (AUB) or menstrual bleeding of abnormal amount, duration, or schedule is a common gynecological condition occurring in up to 50% of women of all age groups. Chronic, heavy, prolonged, or irregular uterine bleeding can lead to anemia, and raise a concern about severe underlying malignancy. Therefore, histopathological examination of the endometrium is critical in evaluating the cause of AUB.

Aims and Objectives: The aims of this study were to study the various histomorphological patterns in endometrial biopsies in cases of AUB.

Materials and Methods: This is a retrospective study done on 212 endometrial tissues in women presenting with AUB. The study is aimed at analyzing the histopathological changes occurring in the endometrium by identifying the cause of bleeding and recording the incidence of various histopathological findings in different age groups.

Results: Proliferative endometrium, the most common histopathological finding, accounted for 51.9% of cases, followed by secretory endometrium (24.5%). Eight cases of disordered proliferative endometrium were found in the present study. Eight cases, accounting for 3.8% of endometrial hyperplasia, were associated with AUB, out of which two cases were found to be complex hyperplasia with atypia. Endometrial carcinoma was seen in two cases associated with AUB. Pregnancy-related changes were found in 7 (3.3%) cases, retained product of conception was the leading cause of bleeding (3 cases).

Conclusion: Histopathological evaluation of endometrium in women presenting with AUB is of paramount importance not only to diagnose various benign conditions but also to detect some highly malignant lesions and precancerous conditions so that early interventions can be started.

Key words: Abnormal Uterine Bleeding; Histopathology; Dilatation and Curettage; Disordered Proliferative Endometrium


 
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How to Cite this Article
Pubmed Style

Bhuyan AP, Talukdar PP, Sarmah A. Histopathological changes in the uterus in women with abnormal uterine bleeding – A 2-year hospital-based retrospective study in a tertiary care center in Assam, India. Natl J Physiol Pharm Pharmacol. 2023; 13(2): 430-433. doi:10.5455/njppp.2023.13.12585202213012023

Web Style

Bhuyan AP, Talukdar PP, Sarmah A. Histopathological changes in the uterus in women with abnormal uterine bleeding – A 2-year hospital-based retrospective study in a tertiary care center in Assam, India. https://www.njppp.com/?mno=93319 [Access: September 03, 2023]. doi:10.5455/njppp.2023.13.12585202213012023

AMA (American Medical Association) Style

Bhuyan AP, Talukdar PP, Sarmah A. Histopathological changes in the uterus in women with abnormal uterine bleeding – A 2-year hospital-based retrospective study in a tertiary care center in Assam, India. Natl J Physiol Pharm Pharmacol. 2023; 13(2): 430-433. doi:10.5455/njppp.2023.13.12585202213012023


Vancouver/ICMJE Style

Bhuyan AP, Talukdar PP, Sarmah A. Histopathological changes in the uterus in women with abnormal uterine bleeding – A 2-year hospital-based retrospective study in a tertiary care center in Assam, India. Natl J Physiol Pharm Pharmacol. (2023), [cited September 03, 2023]; 13(2): 430-433. doi:10.5455/njppp.2023.13.12585202213012023


Harvard Style

Bhuyan, A. P., Talukdar, . P. P. & Sarmah, . A. (2023) Histopathological changes in the uterus in women with abnormal uterine bleeding – A 2-year hospital-based retrospective study in a tertiary care center in Assam, India. Natl J Physiol Pharm Pharmacol, 13 (2), 430-433. doi:10.5455/njppp.2023.13.12585202213012023


Turabian Style

Bhuyan, Akash Pradeep, Partha Pratim Talukdar, and Amrit Sarmah. 2023. Histopathological changes in the uterus in women with abnormal uterine bleeding – A 2-year hospital-based retrospective study in a tertiary care center in Assam, India. National Journal of Physiology, Pharmacy and Pharmacology, 13 (2), 430-433. doi:10.5455/njppp.2023.13.12585202213012023


Chicago Style

Bhuyan, Akash Pradeep, Partha Pratim Talukdar, and Amrit Sarmah. "Histopathological changes in the uterus in women with abnormal uterine bleeding – A 2-year hospital-based retrospective study in a tertiary care center in Assam, India." National Journal of Physiology, Pharmacy and Pharmacology 13 (2023), 430-433. doi:10.5455/njppp.2023.13.12585202213012023


MLA (The Modern Language Association) Style

Bhuyan, Akash Pradeep, Partha Pratim Talukdar, and Amrit Sarmah. "Histopathological changes in the uterus in women with abnormal uterine bleeding – A 2-year hospital-based retrospective study in a tertiary care center in Assam, India." National Journal of Physiology, Pharmacy and Pharmacology 13.2 (2023), 430-433. Print. doi:10.5455/njppp.2023.13.12585202213012023


APA (American Psychological Association) Style

Bhuyan, A. P., Talukdar, . P. P. & Sarmah, . A. (2023) Histopathological changes in the uterus in women with abnormal uterine bleeding – A 2-year hospital-based retrospective study in a tertiary care center in Assam, India. National Journal of Physiology, Pharmacy and Pharmacology, 13 (2), 430-433. doi:10.5455/njppp.2023.13.12585202213012023


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