E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research

Online Publishing Date:
19 / 08 / 2022

 


Correlation of oxidative stress and metabolic risk factors in apparently healthy adults

Alok Pal, Amar Deep Patel, Vandana Gupta, Vani Gupta, Nar Singh Verma.


Abstract
Background: Diabetes, hypertension, obesity, and dyslipidemia, all are the risk factors of metabolic syndrome (MS). Various studies have shown that each risk factor is associated with increased inflammation. hsCRP is a non-specific, sensitive inflammatory marker that is raised in various inflammatory conditions. Similarly, glutathione is an antioxidant which binds with ROS produced during inflammation and reduces damage caused by ROS.

Aims and Objectives: This study has been planned to find the correlation between oxidative stress and metabolic risk factors in apparently healthy adults.

Materials and Methods: We recruited apparently healthy adults (n = 120) and measured waist circumference, blood pressure, lipid profile, Fasting blood sugar, serum GSH, and hsCRP in all the subjects. Seventy-seven subjects were found to have at least one or more metabolic risk factors (Group A) according to NCEP ATP III criteria with waist circumference >90 cm for male and >80 cm for female and 43 were without any metabolic risk factors (Group B). Thereafter, we compared the serum levels of hsCRP and serum GSH with persons having one or more risk factors for MS.

Results: In this study, we observed that subjects with metabolic risk factors were having more oxidative stress indicated by increased hsCRP (4783.1 ± 2060.21) and low serum GSH (3.17 ± 0.81) in comparison to controls (1640.5 ± 547.47 and 4.79 ± 0.77, respectively). This increase in hsCRP and decrease in GSH in case group was statistically significant. We also found the higher basal hsCRP levels in control group as per AHA/CDC study.

Conclusion: We observed in this study that Indians without any risk factors for MS have relatively higher CRP levels and are at intermediate risk for cardiovascular disease. It was also observed that as the number of metabolic risk factors increases, the levels of hsCRP increases, and serum GSH decreases. This indicates that more risk factors are associated with higher oxidative stress.

Key words: Metabolic Risk Factors; hsCRP; GSH; Glutathione; Inflammation


 
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How to Cite this Article
Pubmed Style

Pal A, Patel AD, Gupta V, Gupta V, Verma NS. Correlation of oxidative stress and metabolic risk factors in apparently healthy adults. Natl J Physiol Pharm Pharmacol. 2023; 13(3): 556-560. doi:10.5455/njppp.2023.13.08382202205082022


Web Style

Pal A, Patel AD, Gupta V, Gupta V, Verma NS. Correlation of oxidative stress and metabolic risk factors in apparently healthy adults. https://www.njppp.com/?mno=90061 [Access: March 14, 2024]. doi:10.5455/njppp.2023.13.08382202205082022


AMA (American Medical Association) Style

Pal A, Patel AD, Gupta V, Gupta V, Verma NS. Correlation of oxidative stress and metabolic risk factors in apparently healthy adults. Natl J Physiol Pharm Pharmacol. 2023; 13(3): 556-560. doi:10.5455/njppp.2023.13.08382202205082022



Vancouver/ICMJE Style

Pal A, Patel AD, Gupta V, Gupta V, Verma NS. Correlation of oxidative stress and metabolic risk factors in apparently healthy adults. Natl J Physiol Pharm Pharmacol. (2023), [cited March 14, 2024]; 13(3): 556-560. doi:10.5455/njppp.2023.13.08382202205082022



Harvard Style

Pal, A., Patel, . A. D., Gupta, . V., Gupta, . V. & Verma, . N. S. (2023) Correlation of oxidative stress and metabolic risk factors in apparently healthy adults. Natl J Physiol Pharm Pharmacol, 13 (3), 556-560. doi:10.5455/njppp.2023.13.08382202205082022



Turabian Style

Pal, Alok, Amar Deep Patel, Vandana Gupta, Vani Gupta, and Nar Singh Verma. 2023. Correlation of oxidative stress and metabolic risk factors in apparently healthy adults. National Journal of Physiology, Pharmacy and Pharmacology, 13 (3), 556-560. doi:10.5455/njppp.2023.13.08382202205082022



Chicago Style

Pal, Alok, Amar Deep Patel, Vandana Gupta, Vani Gupta, and Nar Singh Verma. "Correlation of oxidative stress and metabolic risk factors in apparently healthy adults." National Journal of Physiology, Pharmacy and Pharmacology 13 (2023), 556-560. doi:10.5455/njppp.2023.13.08382202205082022



MLA (The Modern Language Association) Style

Pal, Alok, Amar Deep Patel, Vandana Gupta, Vani Gupta, and Nar Singh Verma. "Correlation of oxidative stress and metabolic risk factors in apparently healthy adults." National Journal of Physiology, Pharmacy and Pharmacology 13.3 (2023), 556-560. Print. doi:10.5455/njppp.2023.13.08382202205082022



APA (American Psychological Association) Style

Pal, A., Patel, . A. D., Gupta, . V., Gupta, . V. & Verma, . N. S. (2023) Correlation of oxidative stress and metabolic risk factors in apparently healthy adults. National Journal of Physiology, Pharmacy and Pharmacology, 13 (3), 556-560. doi:10.5455/njppp.2023.13.08382202205082022