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Case Report 


Role of visual evoked potential as a window to detect functional changes that occur without signs of diabetic retinopathy in fundoscopy: Case series involving symptomatic overt diabetic pregnant women

Akriti Kapila Sharma, Latika Mohan, Sunita Mittal, Srikant Sekar, Anupama Bahadur, Ruby Gupta, Anupam Singh.

Abstract
Diabetic retinopathy (DR) is a microvascular complication associated with diabetes mellitus. Pregnancy is a major risk factor for DR in diabetic women. Recent evidenced suggests that in course of DR functional changes including damage of pre-ganglionic and ganglionic cells in retina precede structural microvascular changes. A number of studies in the past have highlighted the role of pattern visual evoked potential (VEP) in detecting such functional changes. However, the study of VEP changes in diabetic pregnancies remains unexplored. This case series has the objective of exploring VEP changes in symptomatic OVD cases, who had no signs of DR on fundoscopy. We present two cases of overt diabetic women who complaint of straining of eyes, headache, and difficulty in reading during pregnancy. Complete ophthalmic examination was done in both the cases followed by a VEP test. VEP test was done as a part of a research project. The ethical clearance for the project was obtained from the Institute’s Ethics Committee before the commencement of the study. Fundoscopic examination in both cases revealed that the retina was within normal limits with no signs of retinopathy. In Case 1, P100 latency was increased for the left eye and was normal for the right eye during the first visit. While P100 latency was increased for both left and right eye during the second visit. There was a substantial increase in P100 latency for both eyes in second visit as compared to first visit. In Case 2, P100 latency was increased for both left and right eye and amplitude decreased for the left eye. This is a case series consisting of symptomatic overt diabetic pregnant women who had increased P100 latency despite no signs of retinopathy in fundoscopy. The previous studies have reported that multiple follow-ups with ophthalmoscopy may not be cost-effective in diabetic pregnant women. VEP provides a window for detection of early functional changes that may help identify at risk patients for follow-up and early intervention.

Key words: Overt Diabetes; Pregnancy; Diabetic Retinopathy; Visual Evoked Potential


 
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How to Cite this Article
Pubmed Style

Sharma AK, Mohan L, Mittal S, Sekar S, Bahadur A, Gupta R, Singh A. Role of visual evoked potential as a window to detect functional changes that occur without signs of diabetic retinopathy in fundoscopy: Case series involving symptomatic overt diabetic pregnant women. Natl J Physiol Pharm Pharmacol. 2023; 13(1): 214-217. doi:10.5455/njppp.2023.13.07358202212122022


Web Style

Sharma AK, Mohan L, Mittal S, Sekar S, Bahadur A, Gupta R, Singh A. Role of visual evoked potential as a window to detect functional changes that occur without signs of diabetic retinopathy in fundoscopy: Case series involving symptomatic overt diabetic pregnant women. https://www.njppp.com/?mno=83715 [Access: February 01, 2023]. doi:10.5455/njppp.2023.13.07358202212122022


AMA (American Medical Association) Style

Sharma AK, Mohan L, Mittal S, Sekar S, Bahadur A, Gupta R, Singh A. Role of visual evoked potential as a window to detect functional changes that occur without signs of diabetic retinopathy in fundoscopy: Case series involving symptomatic overt diabetic pregnant women. Natl J Physiol Pharm Pharmacol. 2023; 13(1): 214-217. doi:10.5455/njppp.2023.13.07358202212122022



Vancouver/ICMJE Style

Sharma AK, Mohan L, Mittal S, Sekar S, Bahadur A, Gupta R, Singh A. Role of visual evoked potential as a window to detect functional changes that occur without signs of diabetic retinopathy in fundoscopy: Case series involving symptomatic overt diabetic pregnant women. Natl J Physiol Pharm Pharmacol. (2023), [cited February 01, 2023]; 13(1): 214-217. doi:10.5455/njppp.2023.13.07358202212122022



Harvard Style

Sharma, A. K., Mohan, . L., Mittal, . S., Sekar, . S., Bahadur, . A., Gupta, . R. & Singh, . A. (2023) Role of visual evoked potential as a window to detect functional changes that occur without signs of diabetic retinopathy in fundoscopy: Case series involving symptomatic overt diabetic pregnant women. Natl J Physiol Pharm Pharmacol, 13 (1), 214-217. doi:10.5455/njppp.2023.13.07358202212122022



Turabian Style

Sharma, Akriti Kapila, Latika Mohan, Sunita Mittal, Srikant Sekar, Anupama Bahadur, Ruby Gupta, and Anupam Singh. 2023. Role of visual evoked potential as a window to detect functional changes that occur without signs of diabetic retinopathy in fundoscopy: Case series involving symptomatic overt diabetic pregnant women. National Journal of Physiology, Pharmacy and Pharmacology, 13 (1), 214-217. doi:10.5455/njppp.2023.13.07358202212122022



Chicago Style

Sharma, Akriti Kapila, Latika Mohan, Sunita Mittal, Srikant Sekar, Anupama Bahadur, Ruby Gupta, and Anupam Singh. "Role of visual evoked potential as a window to detect functional changes that occur without signs of diabetic retinopathy in fundoscopy: Case series involving symptomatic overt diabetic pregnant women." National Journal of Physiology, Pharmacy and Pharmacology 13 (2023), 214-217. doi:10.5455/njppp.2023.13.07358202212122022



MLA (The Modern Language Association) Style

Sharma, Akriti Kapila, Latika Mohan, Sunita Mittal, Srikant Sekar, Anupama Bahadur, Ruby Gupta, and Anupam Singh. "Role of visual evoked potential as a window to detect functional changes that occur without signs of diabetic retinopathy in fundoscopy: Case series involving symptomatic overt diabetic pregnant women." National Journal of Physiology, Pharmacy and Pharmacology 13.1 (2023), 214-217. Print. doi:10.5455/njppp.2023.13.07358202212122022



APA (American Psychological Association) Style

Sharma, A. K., Mohan, . L., Mittal, . S., Sekar, . S., Bahadur, . A., Gupta, . R. & Singh, . A. (2023) Role of visual evoked potential as a window to detect functional changes that occur without signs of diabetic retinopathy in fundoscopy: Case series involving symptomatic overt diabetic pregnant women. National Journal of Physiology, Pharmacy and Pharmacology, 13 (1), 214-217. doi:10.5455/njppp.2023.13.07358202212122022