E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Association of insulin resistance and lipid profile with serum T3, T4, and TSH in patients with hypothyroidism

Divya Unnikrishnan, Jean Maliekkal, Geetha N.

Abstract
Background: Hypothyroidism is a common endocrine derangement met with in clinical practice. Deficiency of thyroid hormones can have a significant effect on lipid and carbohydrate metabolism.

Aims and Objectives: The aim of the study was to study the association of insulin resistance and lipid profile with serum triiodothyronine (T3), tetraiodothyronine (T4), and thyroid-stimulating hormone (TSH) in hypothyroidism.

Materials and Methods: A comparative cross-sectional study was conducted in a tertiary care hospital after obtaining clearance from the Institutional Ethics Committee. Thirty primary hypothyroid subjects were selected as cases based on their TSH values (>4 uIU/mL) and thirty normal subjects as controls after proper exclusion and after getting the informed consent. Their fasting plasma glucose levels, lipid profile, and serum T3, T4, TSH were measured. Homeostasis model Assessment using OXFORD HOMA 2 CALCULATOR was used to determine the insulin resistance (HOMA-IR).

Results: The mean values of HOMA-IR, total cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides were significantly higher in hypothyroid group than in normal controls. HOMA-IR showed a significant negative correlation with T3 and T4. The correlations of HOMA-IR, total cholesterol, LDL cholesterol, and triglycerides with TSH were positive.

Conclusion: The present study shows that hypothyroidism leads to an elevated insulin resistance and dyslipidemia.

Key words: Hypothyroidism; Lipid Profile; Insulin Resistance; HOMA-IR; Triiodothyronine; Tetraiodothyronine; Thyroid-Stimulating Hormone


 
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How to Cite this Article
Pubmed Style

Unnikrishnan D, Maliekkal J, N G. Association of insulin resistance and lipid profile with serum T3, T4, and TSH in patients with hypothyroidism. Natl J Physiol Pharm Pharmacol. 2023; 13(3): 499-503. doi:10.5455/njppp.2023.13.07357202221072022


Web Style

Unnikrishnan D, Maliekkal J, N G. Association of insulin resistance and lipid profile with serum T3, T4, and TSH in patients with hypothyroidism. https://www.njppp.com/?mno=80738 [Access: February 01, 2024]. doi:10.5455/njppp.2023.13.07357202221072022


AMA (American Medical Association) Style

Unnikrishnan D, Maliekkal J, N G. Association of insulin resistance and lipid profile with serum T3, T4, and TSH in patients with hypothyroidism. Natl J Physiol Pharm Pharmacol. 2023; 13(3): 499-503. doi:10.5455/njppp.2023.13.07357202221072022



Vancouver/ICMJE Style

Unnikrishnan D, Maliekkal J, N G. Association of insulin resistance and lipid profile with serum T3, T4, and TSH in patients with hypothyroidism. Natl J Physiol Pharm Pharmacol. (2023), [cited February 01, 2024]; 13(3): 499-503. doi:10.5455/njppp.2023.13.07357202221072022



Harvard Style

Unnikrishnan, D., Maliekkal, . J. & N, . G. (2023) Association of insulin resistance and lipid profile with serum T3, T4, and TSH in patients with hypothyroidism. Natl J Physiol Pharm Pharmacol, 13 (3), 499-503. doi:10.5455/njppp.2023.13.07357202221072022



Turabian Style

Unnikrishnan, Divya, Jean Maliekkal, and Geetha N. 2023. Association of insulin resistance and lipid profile with serum T3, T4, and TSH in patients with hypothyroidism. National Journal of Physiology, Pharmacy and Pharmacology, 13 (3), 499-503. doi:10.5455/njppp.2023.13.07357202221072022



Chicago Style

Unnikrishnan, Divya, Jean Maliekkal, and Geetha N. "Association of insulin resistance and lipid profile with serum T3, T4, and TSH in patients with hypothyroidism." National Journal of Physiology, Pharmacy and Pharmacology 13 (2023), 499-503. doi:10.5455/njppp.2023.13.07357202221072022



MLA (The Modern Language Association) Style

Unnikrishnan, Divya, Jean Maliekkal, and Geetha N. "Association of insulin resistance and lipid profile with serum T3, T4, and TSH in patients with hypothyroidism." National Journal of Physiology, Pharmacy and Pharmacology 13.3 (2023), 499-503. Print. doi:10.5455/njppp.2023.13.07357202221072022



APA (American Psychological Association) Style

Unnikrishnan, D., Maliekkal, . J. & N, . G. (2023) Association of insulin resistance and lipid profile with serum T3, T4, and TSH in patients with hypothyroidism. National Journal of Physiology, Pharmacy and Pharmacology, 13 (3), 499-503. doi:10.5455/njppp.2023.13.07357202221072022