E-ISSN 2231-3206 | ISSN 2320-4672
 

Review Article 


Current theories of pathophysiology and potential therapeutic targets of COVID-19: What we know so far

Megha Agrawal, Gyan Vardhan, Vikas Kumar, Puneet Dhamija.

Abstract
In 2019, a new variant of coronavirus emerged that put the whole world on a standstill due to its unprecedented spread and morbidity. Since then, scientists have been working on several theories to explain the origin and pathogenesis of the virus. Over this period of time, it has been observed clinically that individual variation exists in the way this virus infects people, its symptomatology and sequelae. The pathophysiology is still unclear. This review was taken up to consolidate all the available information until date about current theories of etiopathogenesis with an understanding of potential therapeutic targets on the mechanisms. This review also highlights the gray areas that need to be addressed in the future. Research papers published up to December 7, 2020 were included based on a search on PubMed, Google Scholar, etc., to get the latest relevant literature on this topic. Coronavirus expresses differently in different individuals, affecting different organ systems, and having variable severity. However, the underlying pathogenic mechanisms are not completely understood. Due to the lack of definite curative therapy, it is essential to explore the basic pathophysiology so as to develop more effective and target-based therapies in the future.

Key words: COVID-19; Current Theories; Pathophysiology; Potential Targets; Etiopathogenesis; Unprecedented Spread


 
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How to Cite this Article
Pubmed Style

Agrawal M, Vardhan G, Kumar V, Dhamija P. Current theories of pathophysiology and potential therapeutic targets of COVID-19: What we know so far. Natl J Physiol Pharm Pharmacol. 2022; 12(7): 907-915. doi:10.5455/njppp.2022.12.05135202223052022


Web Style

Agrawal M, Vardhan G, Kumar V, Dhamija P. Current theories of pathophysiology and potential therapeutic targets of COVID-19: What we know so far. https://www.njppp.com/?mno=78340 [Access: December 01, 2022]. doi:10.5455/njppp.2022.12.05135202223052022


AMA (American Medical Association) Style

Agrawal M, Vardhan G, Kumar V, Dhamija P. Current theories of pathophysiology and potential therapeutic targets of COVID-19: What we know so far. Natl J Physiol Pharm Pharmacol. 2022; 12(7): 907-915. doi:10.5455/njppp.2022.12.05135202223052022



Vancouver/ICMJE Style

Agrawal M, Vardhan G, Kumar V, Dhamija P. Current theories of pathophysiology and potential therapeutic targets of COVID-19: What we know so far. Natl J Physiol Pharm Pharmacol. (2022), [cited December 01, 2022]; 12(7): 907-915. doi:10.5455/njppp.2022.12.05135202223052022



Harvard Style

Agrawal, M., Vardhan, . G., Kumar, . V. & Dhamija, . P. (2022) Current theories of pathophysiology and potential therapeutic targets of COVID-19: What we know so far. Natl J Physiol Pharm Pharmacol, 12 (7), 907-915. doi:10.5455/njppp.2022.12.05135202223052022



Turabian Style

Agrawal, Megha, Gyan Vardhan, Vikas Kumar, and Puneet Dhamija. 2022. Current theories of pathophysiology and potential therapeutic targets of COVID-19: What we know so far. National Journal of Physiology, Pharmacy and Pharmacology, 12 (7), 907-915. doi:10.5455/njppp.2022.12.05135202223052022



Chicago Style

Agrawal, Megha, Gyan Vardhan, Vikas Kumar, and Puneet Dhamija. "Current theories of pathophysiology and potential therapeutic targets of COVID-19: What we know so far." National Journal of Physiology, Pharmacy and Pharmacology 12 (2022), 907-915. doi:10.5455/njppp.2022.12.05135202223052022



MLA (The Modern Language Association) Style

Agrawal, Megha, Gyan Vardhan, Vikas Kumar, and Puneet Dhamija. "Current theories of pathophysiology and potential therapeutic targets of COVID-19: What we know so far." National Journal of Physiology, Pharmacy and Pharmacology 12.7 (2022), 907-915. Print. doi:10.5455/njppp.2022.12.05135202223052022



APA (American Psychological Association) Style

Agrawal, M., Vardhan, . G., Kumar, . V. & Dhamija, . P. (2022) Current theories of pathophysiology and potential therapeutic targets of COVID-19: What we know so far. National Journal of Physiology, Pharmacy and Pharmacology, 12 (7), 907-915. doi:10.5455/njppp.2022.12.05135202223052022