Efficacy of dexmedetomidine as adjuvant to ropivacaine in paravertebral block for post-operative analgesia in breast cancer surgery

Deepti Swain; Asitkumar Sethi; Prasantkumar Bal; Kamalakanta Swain; Sidharth Sraban Routray

doi:10.5455/njppp.2023.13.07331202207072022

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Original Research
Online Published: 16 Jul 2022

Natl J Physiol Pharm Pharmacol. 2023; 13(2): 340-343

doi: 10.5455/njppp.2023.13.07331202207072022

Efficacy of dexmedetomidine as adjuvant to ropivacaine in paravertebral block for post-operative analgesia in breast cancer surgery

Deepti Swain, Asitkumar Sethi, Prasantkumar Bal, Kamalakanta Swain, Sidharth Sraban Routray.

Abstract
Background: Paravertebral block can be given for pain management after modified radical mastectomy (MRM). Although many additives to ropivacaine in PVB have been tried for post-operative analgesia, none has been found ideal.

Aims and Objectives: We have compared the duration of analgesia in PVB using adjuvant like dexmedetomidine with ropivacaine after MRM.

Materials and Methods: Sixty female patients posted for MRM and axillary dissection were split into two groups. Group R administered ultrasound-guided PVB with 20 ml ropivacaine 0.5% and Group RD administered 20 ml of 0.5% ropivacaine with dexmedetomidine 1 mcg/kg. After confirming PVB, surgery was done under general anesthesia in all patients. Time for 1st analgesia requirement was the main objective of our trial. Other objectives were to record visual analog scale scores and total analgesic need.

Results: Post-operative analgesia duration was increased in the group RD (7.11 ± 1.42 h) in contrary to Group R (3.68 ± 1.85 h). Total paracetamol consumption post-operative 24 h was decreased in Group RD (1.63 ±0.89 g) in contrary to Group R (2.74 ± 0.76 g).

Conclusion: Dexmedetomidine in PVB provides prolonged pain relief after MRM.

Key words: Dexmedetomidine; Ropivacaine; PVB; Analgesia

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How to Cite this Article

Pubmed Style

Swain D, Sethi A, Bal P, Swain K, Routray SS. Efficacy of dexmedetomidine as adjuvant to ropivacaine in paravertebral block for post-operative analgesia in breast cancer surgery. Natl J Physiol Pharm Pharmacol. 2023; 13(2): 340-343. doi:10.5455/njppp.2023.13.07331202207072022

Web Style

Swain D, Sethi A, Bal P, Swain K, Routray SS. Efficacy of dexmedetomidine as adjuvant to ropivacaine in paravertebral block for post-operative analgesia in breast cancer surgery. https://www.njppp.com/?mno=76189 [Access: May 06, 2025]. doi:10.5455/njppp.2023.13.07331202207072022

AMA (American Medical Association) Style

Swain D, Sethi A, Bal P, Swain K, Routray SS. Efficacy of dexmedetomidine as adjuvant to ropivacaine in paravertebral block for post-operative analgesia in breast cancer surgery. Natl J Physiol Pharm Pharmacol. 2023; 13(2): 340-343. doi:10.5455/njppp.2023.13.07331202207072022

Vancouver/ICMJE Style

Swain D, Sethi A, Bal P, Swain K, Routray SS. Efficacy of dexmedetomidine as adjuvant to ropivacaine in paravertebral block for post-operative analgesia in breast cancer surgery. Natl J Physiol Pharm Pharmacol. (2023), [cited May 06, 2025]; 13(2): 340-343. doi:10.5455/njppp.2023.13.07331202207072022

Harvard Style

Swain, D., Sethi, . A., Bal, . P., Swain, . K. & Routray, . S. S. (2023) Efficacy of dexmedetomidine as adjuvant to ropivacaine in paravertebral block for post-operative analgesia in breast cancer surgery. Natl J Physiol Pharm Pharmacol, 13 (2), 340-343. doi:10.5455/njppp.2023.13.07331202207072022

Turabian Style

Swain, Deepti, Asitkumar Sethi, Prasantkumar Bal, Kamalakanta Swain, and Sidharth Sraban Routray. 2023. Efficacy of dexmedetomidine as adjuvant to ropivacaine in paravertebral block for post-operative analgesia in breast cancer surgery. National Journal of Physiology, Pharmacy and Pharmacology, 13 (2), 340-343. doi:10.5455/njppp.2023.13.07331202207072022

Chicago Style

Swain, Deepti, Asitkumar Sethi, Prasantkumar Bal, Kamalakanta Swain, and Sidharth Sraban Routray. "Efficacy of dexmedetomidine as adjuvant to ropivacaine in paravertebral block for post-operative analgesia in breast cancer surgery." National Journal of Physiology, Pharmacy and Pharmacology 13 (2023), 340-343. doi:10.5455/njppp.2023.13.07331202207072022

MLA (The Modern Language Association) Style

Swain, Deepti, Asitkumar Sethi, Prasantkumar Bal, Kamalakanta Swain, and Sidharth Sraban Routray. "Efficacy of dexmedetomidine as adjuvant to ropivacaine in paravertebral block for post-operative analgesia in breast cancer surgery." National Journal of Physiology, Pharmacy and Pharmacology 13.2 (2023), 340-343. Print. doi:10.5455/njppp.2023.13.07331202207072022

APA (American Psychological Association) Style

Swain, D., Sethi, . A., Bal, . P., Swain, . K. & Routray, . S. S. (2023) Efficacy of dexmedetomidine as adjuvant to ropivacaine in paravertebral block for post-operative analgesia in breast cancer surgery. National Journal of Physiology, Pharmacy and Pharmacology, 13 (2), 340-343. doi:10.5455/njppp.2023.13.07331202207072022

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