E-ISSN 2231-3206 | ISSN 2320-4672
 

Case Series 


N-acetyl cysteine in management of toxic epidermal necrolysis: A case series

Sumir Kumar, Narvinderjeet Kaur, Sukhmani Kaur Brar, Rubeena Bano.

Abstract
Steven–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are a severe form of adverse drug reactions with significant morbidity and mortality. No definitive treatment is available for SJS/TEN. Multiple drugs such as corticosteroids and cyclosporine have been used with doubtful efficacy. In recent years, few successful reports of N-acetylcysteine use are reported in this disorder. Multiple modes of action have been postulated for its effectiveness in SJS/TEN. Antioxidant action is one of the proposed mechanisms. We tried n-acetyl cysteine in 5 patients of SJS/TEN as per paracetamol poisoning protocol. All 5 patients showed favorable outcome and discharged in satisfactory condition.

Key words: N-acetyl Cysteine; Toxic Epidermal Necrolysis; Case Series; Steven–Johnson Syndrome


 
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How to Cite this Article
Pubmed Style

Kumar S, Kaur N, Brar SK, Bano R. N-acetyl cysteine in management of toxic epidermal necrolysis: A case series. Natl J Physiol Pharm Pharmacol. 2021; 11(9): 1069-1072. doi:10.5455/njppp.2021.11.04111202113042021


Web Style

Kumar S, Kaur N, Brar SK, Bano R. N-acetyl cysteine in management of toxic epidermal necrolysis: A case series. http://www.njppp.com/?mno=72112 [Access: September 01, 2021]. doi:10.5455/njppp.2021.11.04111202113042021


AMA (American Medical Association) Style

Kumar S, Kaur N, Brar SK, Bano R. N-acetyl cysteine in management of toxic epidermal necrolysis: A case series. Natl J Physiol Pharm Pharmacol. 2021; 11(9): 1069-1072. doi:10.5455/njppp.2021.11.04111202113042021



Vancouver/ICMJE Style

Kumar S, Kaur N, Brar SK, Bano R. N-acetyl cysteine in management of toxic epidermal necrolysis: A case series. Natl J Physiol Pharm Pharmacol. (2021), [cited September 01, 2021]; 11(9): 1069-1072. doi:10.5455/njppp.2021.11.04111202113042021



Harvard Style

Kumar, S., Kaur, . N., Brar, . S. K. & Bano, . R. (2021) N-acetyl cysteine in management of toxic epidermal necrolysis: A case series. Natl J Physiol Pharm Pharmacol, 11 (9), 1069-1072. doi:10.5455/njppp.2021.11.04111202113042021



Turabian Style

Kumar, Sumir, Narvinderjeet Kaur, Sukhmani Kaur Brar, and Rubeena Bano. 2021. N-acetyl cysteine in management of toxic epidermal necrolysis: A case series. National Journal of Physiology, Pharmacy and Pharmacology, 11 (9), 1069-1072. doi:10.5455/njppp.2021.11.04111202113042021



Chicago Style

Kumar, Sumir, Narvinderjeet Kaur, Sukhmani Kaur Brar, and Rubeena Bano. "N-acetyl cysteine in management of toxic epidermal necrolysis: A case series." National Journal of Physiology, Pharmacy and Pharmacology 11 (2021), 1069-1072. doi:10.5455/njppp.2021.11.04111202113042021



MLA (The Modern Language Association) Style

Kumar, Sumir, Narvinderjeet Kaur, Sukhmani Kaur Brar, and Rubeena Bano. "N-acetyl cysteine in management of toxic epidermal necrolysis: A case series." National Journal of Physiology, Pharmacy and Pharmacology 11.9 (2021), 1069-1072. Print. doi:10.5455/njppp.2021.11.04111202113042021



APA (American Psychological Association) Style

Kumar, S., Kaur, . N., Brar, . S. K. & Bano, . R. (2021) N-acetyl cysteine in management of toxic epidermal necrolysis: A case series. National Journal of Physiology, Pharmacy and Pharmacology, 11 (9), 1069-1072. doi:10.5455/njppp.2021.11.04111202113042021