Antihypertensive effects of Moringa oleifera leaf extract Lam. (Moringaceae) in NG-nitro-L-arginine-methyl ester-induced hypertensive rats

Adam Gbankoto; Mariette Sindete; Marius Adjagba; Machioud Maxime Sangare; Eugene Selidji Attakpa; Bonaventure Awede

doi:10.5455/njppp.2019.9.1034231102019

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Online Published: 15 Nov 2019

Natl J Physiol Pharm Pharmacol. 2019; 9(12): 1257-1266

doi: 10.5455/njppp.2019.9.1034231102019

Antihypertensive effects of Moringa oleifera leaf extract Lam. (Moringaceae) in NG-nitro-L-arginine-methyl ester-induced hypertensive rats

Adam Gbankoto, Mariette Sindete, Marius Adjagba, Machioud Maxime Sangare, Eugene Selidji Attakpa, Bonaventure Awede.

Cited By:12

Abstract
Background: The use of natural products such as Moringa oleifera (MO) for the improvement of resistance artery relaxation is a potential strategy for the prevention and treatment of hypertension.

Aims and Objective: The present study was designed to evaluate the protective effect of MO hydro-ethanol extract on NG-nitro-L-arginine-methyl ester (L-NAME)-induced hypertension and the toxicity profile in Wistar rats and shrimp larvae.

Materials and Methods: An experimental hypertensive model was established by administration of L-NAME at 40 mg/kg body weight (BW) by oral gavages to male Wistar rats for 2 weeks and treated with hydro-ethanol extract of MO leaves and losartan. The control group received distilled water. L-NAME group was treated with L-NAME and distilled water. L-NAME-Losartan group was treated with L-NAME and losartan at 100 mg/kg BW. L-NAME-MO group was treated with L-NAME and the hydroethanol extract of MO leaves at 500 mg/kg BW. Blood pressure (BP) was measured by tail cuff method. In vitro toxicity study of the extract was performed on Artemia salina larvae using a biological test for the determination of shrimp lethality. A 14 days acute oral toxicity study was evaluated in female rats on a single dose of 2000 mg/kg BW of hydro-ethanol extract of MO.

Results: L-NAME treated rats developed significantly increased BP from 110.20 ± 4.46 mmHg to 159.60 ± 4.38 mmHg. Concurrent oral treatment with hydro-ethanol extract of MO leaves decreased the high BP from 159.60 ± 4.38 mmHg to 102.40 ± 5.07 mmHg. No harm was observed at the tested doses in vitro and in vivo toxicity studies.

Conclusion: These findings suggest that MO leaves may be potentially useful as a natural product against hypertension.

Key words: Moringa oleifera; Hypertension; NG-Nitro-L-Arginine-Methyl Ester; Wistar Rat; Toxicity

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Pubmed Style

Gbankoto A, Sindete M, Adjagba M, Sangare MM, Attakpa ES, Awede B. Antihypertensive effects of Moringa oleifera leaf extract Lam. (Moringaceae) in NG-nitro-L-arginine-methyl ester-induced hypertensive rats. Natl J Physiol Pharm Pharmacol. 2019; 9(12): 1257-1266.

doi:10.5455/njppp.2019.9.1034231102019

Web Style

Gbankoto A, Sindete M, Adjagba M, Sangare MM, Attakpa ES, Awede B. Antihypertensive effects of Moringa oleifera leaf extract Lam. (Moringaceae) in NG-nitro-L-arginine-methyl ester-induced hypertensive rats. https://www.njppp.com/?mno=68480 [Access: June 26, 2026].

doi:10.5455/njppp.2019.9.1034231102019

AMA (American Medical Association) Style

Gbankoto A, Sindete M, Adjagba M, Sangare MM, Attakpa ES, Awede B. Antihypertensive effects of Moringa oleifera leaf extract Lam. (Moringaceae) in NG-nitro-L-arginine-methyl ester-induced hypertensive rats. Natl J Physiol Pharm Pharmacol. 2019; 9(12): 1257-1266.

doi:10.5455/njppp.2019.9.1034231102019

Vancouver/ICMJE Style

Gbankoto A, Sindete M, Adjagba M, Sangare MM, Attakpa ES, Awede B. Antihypertensive effects of Moringa oleifera leaf extract Lam. (Moringaceae) in NG-nitro-L-arginine-methyl ester-induced hypertensive rats. Natl J Physiol Pharm Pharmacol. (2019), [cited June 26, 2026]; 9(12): 1257-1266.

doi:10.5455/njppp.2019.9.1034231102019

Harvard Style

Gbankoto, A., Sindete, . M., Adjagba, . M., Sangare, . M. M., Attakpa, . E. S. & Awede, . B. (2019) Antihypertensive effects of Moringa oleifera leaf extract Lam. (Moringaceae) in NG-nitro-L-arginine-methyl ester-induced hypertensive rats. Natl J Physiol Pharm Pharmacol, 9 (12), 1257-1266.

doi:10.5455/njppp.2019.9.1034231102019

Turabian Style

Gbankoto, Adam, Mariette Sindete, Marius Adjagba, Machioud Maxime Sangare, Eugene Selidji Attakpa, and Bonaventure Awede. 2019. Antihypertensive effects of Moringa oleifera leaf extract Lam. (Moringaceae) in NG-nitro-L-arginine-methyl ester-induced hypertensive rats. National Journal of Physiology, Pharmacy and Pharmacology, 9 (12), 1257-1266.

doi:10.5455/njppp.2019.9.1034231102019

Chicago Style

Gbankoto, Adam, Mariette Sindete, Marius Adjagba, Machioud Maxime Sangare, Eugene Selidji Attakpa, and Bonaventure Awede. "Antihypertensive effects of Moringa oleifera leaf extract Lam. (Moringaceae) in NG-nitro-L-arginine-methyl ester-induced hypertensive rats." National Journal of Physiology, Pharmacy and Pharmacology 9 (2019), 1257-1266.

doi:10.5455/njppp.2019.9.1034231102019

MLA (The Modern Language Association) Style

doi:10.5455/njppp.2019.9.1034231102019

APA (American Psychological Association) Style

doi:10.5455/njppp.2019.9.1034231102019

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