E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


A study of angiogenic activity of “Hibiscus rosa-sinensis Linn.” using chick chorioallantoic membrane model

Sandhya Sharma, Karunakar Kota, Nilay D Pandya.

Abstract
Background: Nowadays, the search for new pharmacotherapy from medicinal plants to treat the peripheral vascular disease, chronic wound healing, and ischemic heart diseases was significantly increased.

Aim and Objective: The current study was done to evaluate the angiogenic activity of ethanolic extract of Hibiscus rosa-sinensis Linn. (EEHR) using chick chorioallantoic membrane (CAM) model.

Materials and Methods: The angiogenic activity of H. rosa-sinensis Linn. (50, 100, 200, and 300 mg/egg) in chick embryos was assessed using chick CAM assay. Pyruvic acid 300 mg/egg was used as standard drug which is used to promote the blood vessels growth.

Results: The outcome of the study confirmed that H. rosa-sinensis contains active constituents (vitamins, proteins, and phytosterols), which possess angiogenic activity and these are probably related to the inhibition of myocardial infarction, peripheral diseases, and chronic wounds. It was exhibited angiogenic activity by triggered neovascularization in concentration dependent manner.

Conclusion: We concluded that EEHR flower possesses significant angiogenic activity and these new blood vessels are participated in circulation of blood cells in chick egg.

Key words: Angiogenic activity; Chick chorioallantoic membrane assay; Neovascularization


 
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How to Cite this Article
Pubmed Style

Sharma S, Kota K, Pandya ND. A study of angiogenic activity of “Hibiscus rosa-sinensis Linn.” using chick chorioallantoic membrane model. Natl J Physiol Pharm Pharmacol. 2021; 11(10): 1080-1084. doi:10.5455/njppp.2021.11.03094202102052021


Web Style

Sharma S, Kota K, Pandya ND. A study of angiogenic activity of “Hibiscus rosa-sinensis Linn.” using chick chorioallantoic membrane model. http://www.njppp.com/?mno=65276 [Access: October 01, 2021]. doi:10.5455/njppp.2021.11.03094202102052021


AMA (American Medical Association) Style

Sharma S, Kota K, Pandya ND. A study of angiogenic activity of “Hibiscus rosa-sinensis Linn.” using chick chorioallantoic membrane model. Natl J Physiol Pharm Pharmacol. 2021; 11(10): 1080-1084. doi:10.5455/njppp.2021.11.03094202102052021



Vancouver/ICMJE Style

Sharma S, Kota K, Pandya ND. A study of angiogenic activity of “Hibiscus rosa-sinensis Linn.” using chick chorioallantoic membrane model. Natl J Physiol Pharm Pharmacol. (2021), [cited October 01, 2021]; 11(10): 1080-1084. doi:10.5455/njppp.2021.11.03094202102052021



Harvard Style

Sharma, S., Kota, . K. & Pandya, . N. D. (2021) A study of angiogenic activity of “Hibiscus rosa-sinensis Linn.” using chick chorioallantoic membrane model. Natl J Physiol Pharm Pharmacol, 11 (10), 1080-1084. doi:10.5455/njppp.2021.11.03094202102052021



Turabian Style

Sharma, Sandhya, Karunakar Kota, and Nilay D Pandya. 2021. A study of angiogenic activity of “Hibiscus rosa-sinensis Linn.” using chick chorioallantoic membrane model. National Journal of Physiology, Pharmacy and Pharmacology, 11 (10), 1080-1084. doi:10.5455/njppp.2021.11.03094202102052021



Chicago Style

Sharma, Sandhya, Karunakar Kota, and Nilay D Pandya. "A study of angiogenic activity of “Hibiscus rosa-sinensis Linn.” using chick chorioallantoic membrane model." National Journal of Physiology, Pharmacy and Pharmacology 11 (2021), 1080-1084. doi:10.5455/njppp.2021.11.03094202102052021



MLA (The Modern Language Association) Style

Sharma, Sandhya, Karunakar Kota, and Nilay D Pandya. "A study of angiogenic activity of “Hibiscus rosa-sinensis Linn.” using chick chorioallantoic membrane model." National Journal of Physiology, Pharmacy and Pharmacology 11.10 (2021), 1080-1084. Print. doi:10.5455/njppp.2021.11.03094202102052021



APA (American Psychological Association) Style

Sharma, S., Kota, . K. & Pandya, . N. D. (2021) A study of angiogenic activity of “Hibiscus rosa-sinensis Linn.” using chick chorioallantoic membrane model. National Journal of Physiology, Pharmacy and Pharmacology, 11 (10), 1080-1084. doi:10.5455/njppp.2021.11.03094202102052021