E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Efficacy and safety of intralesional quadrivalent human papillomavirus vaccine as immunotherapy in management of recalcitrant genital warts in a tertiary health care center of North India

Sumir Kumar, Onkar Singh, Sukhmani Kaur Brar, Sukhpreet Kaur Gill.

Abstract
Background: Warts are common epidermal outgrowths caused by various strains of Human Papilloma Virus (HPV) and are spread by direct or indirect contact. Although they undergo spontaneous remission in 6070% of cases over a period of few years, the cosmetic disfigurement, tendency to spread, and associated poor quality of life warrants intervention.

Aim and Objectives: The purpose of this case study was to explore the efficacy of Intralesional quadrivalent HPV Vaccine as immunotherapy in management of genital warts.

Materials and Methods: Twelve subjects of genital warts were enrolled from outpatient department of dermatology. Intralesional HPV vaccine was administered at 3 weekly intervals till three sittings or till the resolution of the lesions occurs, whichever was earlier. Results were measured in the terms of reduction in the number of the lesions, size of lesions or appearance of the new lesions. Follow-up was done at 3 weeks, 6 weeks, 9 weeks, 6 months, and 1 year. Any side effects seen during the study were recorded.

Results: Eleven out of 12 patients showed complete resolution. Side effect observed was only pain and that too during the injection. Only one patient had recurrence.

Conclusion: Immunotherapy is a simple, cost effective, and non-ablative mode of treatment for genital warts with better efficacy, tolerability, and less recurrence rate.

Key words: Genital Warts; Human Papillomavirus; Immunotherapy


 
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How to Cite this Article
Pubmed Style

Kumar S, Singh O, Brar SK, Gill SK. Efficacy and safety of intralesional quadrivalent human papillomavirus vaccine as immunotherapy in management of recalcitrant genital warts in a tertiary health care center of North India. Natl J Physiol Pharm Pharmacol. 2021; 11(5): 540-543. doi:10.5455/njppp.2021.11.03083202115032021


Web Style

Kumar S, Singh O, Brar SK, Gill SK. Efficacy and safety of intralesional quadrivalent human papillomavirus vaccine as immunotherapy in management of recalcitrant genital warts in a tertiary health care center of North India. http://www.njppp.com/?mno=63061 [Access: May 01, 2021]. doi:10.5455/njppp.2021.11.03083202115032021


AMA (American Medical Association) Style

Kumar S, Singh O, Brar SK, Gill SK. Efficacy and safety of intralesional quadrivalent human papillomavirus vaccine as immunotherapy in management of recalcitrant genital warts in a tertiary health care center of North India. Natl J Physiol Pharm Pharmacol. 2021; 11(5): 540-543. doi:10.5455/njppp.2021.11.03083202115032021



Vancouver/ICMJE Style

Kumar S, Singh O, Brar SK, Gill SK. Efficacy and safety of intralesional quadrivalent human papillomavirus vaccine as immunotherapy in management of recalcitrant genital warts in a tertiary health care center of North India. Natl J Physiol Pharm Pharmacol. (2021), [cited May 01, 2021]; 11(5): 540-543. doi:10.5455/njppp.2021.11.03083202115032021



Harvard Style

Kumar, S., Singh, . O., Brar, . S. K. & Gill, . S. K. (2021) Efficacy and safety of intralesional quadrivalent human papillomavirus vaccine as immunotherapy in management of recalcitrant genital warts in a tertiary health care center of North India. Natl J Physiol Pharm Pharmacol, 11 (5), 540-543. doi:10.5455/njppp.2021.11.03083202115032021



Turabian Style

Kumar, Sumir, Onkar Singh, Sukhmani Kaur Brar, and Sukhpreet Kaur Gill. 2021. Efficacy and safety of intralesional quadrivalent human papillomavirus vaccine as immunotherapy in management of recalcitrant genital warts in a tertiary health care center of North India. National Journal of Physiology, Pharmacy and Pharmacology, 11 (5), 540-543. doi:10.5455/njppp.2021.11.03083202115032021



Chicago Style

Kumar, Sumir, Onkar Singh, Sukhmani Kaur Brar, and Sukhpreet Kaur Gill. "Efficacy and safety of intralesional quadrivalent human papillomavirus vaccine as immunotherapy in management of recalcitrant genital warts in a tertiary health care center of North India." National Journal of Physiology, Pharmacy and Pharmacology 11 (2021), 540-543. doi:10.5455/njppp.2021.11.03083202115032021



MLA (The Modern Language Association) Style

Kumar, Sumir, Onkar Singh, Sukhmani Kaur Brar, and Sukhpreet Kaur Gill. "Efficacy and safety of intralesional quadrivalent human papillomavirus vaccine as immunotherapy in management of recalcitrant genital warts in a tertiary health care center of North India." National Journal of Physiology, Pharmacy and Pharmacology 11.5 (2021), 540-543. Print. doi:10.5455/njppp.2021.11.03083202115032021



APA (American Psychological Association) Style

Kumar, S., Singh, . O., Brar, . S. K. & Gill, . S. K. (2021) Efficacy and safety of intralesional quadrivalent human papillomavirus vaccine as immunotherapy in management of recalcitrant genital warts in a tertiary health care center of North India. National Journal of Physiology, Pharmacy and Pharmacology, 11 (5), 540-543. doi:10.5455/njppp.2021.11.03083202115032021