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A comparative study on efficacy and safety of tablet duloxetine 60 mg and tablet gabapentin 300 mg among patients with diabetic polyneuropathy – A randomized double-blind study

Syed Mubishera Begum, K P Poojitha, Gondi Surendra Kumar, P Ushakiran.

Abstract
Background: Diabetic peripheral neuropathy is defined as the presence of symptoms and signs of peripheral nerve damage among patients with diabetes, after ruling out other potential causes. Diabetic neuropathies are one among the most common long-term complications of diabetes. About 60% of diabetic patients are affected by neuropathy.

Aim and Objectives: This study aims to study the efficacy and safety of tablet duloxetine 60 mg and tablet gabapentin 300 mg among patients with diabetic polyneuropathy.

Materials and Methods: This study was randomized, comparative, double-blind parallel group study which was conducted for a period of 6 months. Sixty patients with diabetic polyneuropathic pain were randomly allocated into two groups. One group received duloxetine 60 mg and other group received gabapentin 300 mg. Efficacy was assessed using visual analog scale (VAS), short form of McGill pain questionnaire, and patients global impression of change score. Safety was assessed using adverse drug reaction profile.

Results: In the duloxetine group, the mean VAS score at the baseline was 54.97 ± 6.75, and at 3 months, it was 20.07 ± 5.32 which was statistically significant. In the gabapentin group, the mean score at baseline was 53.57 ± 7.85, and at 3 months, it was 26.57 ± 4.39 which was also statistically significant. The difference between the baseline and 3rd month mean McGill score in both groups was statistically significant.

Conclusions: We found that both duloxetine 60 mg once daily and gabapentin 300 mg once daily are effective in the treatment of diabetic polyneuropathic pain. However, duloxetine 60 mg once daily is more efficacious than gabapentin 300 mg once daily in the treatment of diabetic neuropathic pain. Both the drugs are well tolerated but gabapentin is better tolerated than duloxetine.

Key words: Duloxetine; Efficacy; Gabapentin; McGill Pain Questionnaire; Visual Analog Scale; Randomized Double-Blind Study


 
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How to Cite this Article
Pubmed Style

Begum SM, Poojitha KP, Kumar GS, Ushakiran P. A comparative study on efficacy and safety of tablet duloxetine 60 mg and tablet gabapentin 300 mg among patients with diabetic polyneuropathy – A randomized double-blind study. Natl J Physiol Pharm Pharmacol. 2023; 13(1): 177-184. doi:10.5455/njppp.2023.13.12578202206122022


Web Style

Begum SM, Poojitha KP, Kumar GS, Ushakiran P. A comparative study on efficacy and safety of tablet duloxetine 60 mg and tablet gabapentin 300 mg among patients with diabetic polyneuropathy – A randomized double-blind study. https://www.njppp.com/?mno=61848 [Access: February 01, 2023]. doi:10.5455/njppp.2023.13.12578202206122022


AMA (American Medical Association) Style

Begum SM, Poojitha KP, Kumar GS, Ushakiran P. A comparative study on efficacy and safety of tablet duloxetine 60 mg and tablet gabapentin 300 mg among patients with diabetic polyneuropathy – A randomized double-blind study. Natl J Physiol Pharm Pharmacol. 2023; 13(1): 177-184. doi:10.5455/njppp.2023.13.12578202206122022



Vancouver/ICMJE Style

Begum SM, Poojitha KP, Kumar GS, Ushakiran P. A comparative study on efficacy and safety of tablet duloxetine 60 mg and tablet gabapentin 300 mg among patients with diabetic polyneuropathy – A randomized double-blind study. Natl J Physiol Pharm Pharmacol. (2023), [cited February 01, 2023]; 13(1): 177-184. doi:10.5455/njppp.2023.13.12578202206122022



Harvard Style

Begum, S. M., Poojitha, . K. P., Kumar, . G. S. & Ushakiran, . P. (2023) A comparative study on efficacy and safety of tablet duloxetine 60 mg and tablet gabapentin 300 mg among patients with diabetic polyneuropathy – A randomized double-blind study. Natl J Physiol Pharm Pharmacol, 13 (1), 177-184. doi:10.5455/njppp.2023.13.12578202206122022



Turabian Style

Begum, Syed Mubishera, K P Poojitha, Gondi Surendra Kumar, and P Ushakiran. 2023. A comparative study on efficacy and safety of tablet duloxetine 60 mg and tablet gabapentin 300 mg among patients with diabetic polyneuropathy – A randomized double-blind study. National Journal of Physiology, Pharmacy and Pharmacology, 13 (1), 177-184. doi:10.5455/njppp.2023.13.12578202206122022



Chicago Style

Begum, Syed Mubishera, K P Poojitha, Gondi Surendra Kumar, and P Ushakiran. "A comparative study on efficacy and safety of tablet duloxetine 60 mg and tablet gabapentin 300 mg among patients with diabetic polyneuropathy – A randomized double-blind study." National Journal of Physiology, Pharmacy and Pharmacology 13 (2023), 177-184. doi:10.5455/njppp.2023.13.12578202206122022



MLA (The Modern Language Association) Style

Begum, Syed Mubishera, K P Poojitha, Gondi Surendra Kumar, and P Ushakiran. "A comparative study on efficacy and safety of tablet duloxetine 60 mg and tablet gabapentin 300 mg among patients with diabetic polyneuropathy – A randomized double-blind study." National Journal of Physiology, Pharmacy and Pharmacology 13.1 (2023), 177-184. Print. doi:10.5455/njppp.2023.13.12578202206122022



APA (American Psychological Association) Style

Begum, S. M., Poojitha, . K. P., Kumar, . G. S. & Ushakiran, . P. (2023) A comparative study on efficacy and safety of tablet duloxetine 60 mg and tablet gabapentin 300 mg among patients with diabetic polyneuropathy – A randomized double-blind study. National Journal of Physiology, Pharmacy and Pharmacology, 13 (1), 177-184. doi:10.5455/njppp.2023.13.12578202206122022