Effect of coadministration of glibenclamide and methanolic stem extract of Anisopus mannii N.E.Br. (Apocynaceae) on glucose homeostasis and lipid profile in streptozotocin/nicotinamide-induced diabetic rats

Aminu Chika; Amina Yahaya

doi:10.5455/njppp.2019.9.0829205092019

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Original Research
Online Published: 09 Sep 2019

Natl J Physiol Pharm Pharmacol. 2019; 9(10): 1045-1051

doi: 10.5455/njppp.2019.9.0829205092019

Effect of coadministration of glibenclamide and methanolic stem extract of Anisopus mannii N.E.Br. (Apocynaceae) on glucose homeostasis and lipid profile in streptozotocin/nicotinamide-induced diabetic rats

Aminu Chika, Amina Yahaya.

Cited By:5

Abstract
Background: Although the antihyperglycemic activity of stem extracts of Anisopus mannii (AM; an antidiabetic ethnomedicinal plant utilized in Northwestern Nigeria) has been reported, the effects of coadministration of the extracts with glibenclamide, a commonly used antihyperglycemic agent, are not known.

Aims and Objectives: The objectives were to determine the effect of simultaneous administration of AM methanolic stem extract with glibenclamide using streptozotocin/nicotinamide-induced diabetic rats.

Materials and Methods: After permission from the departmental ethics committee, male Wistar rats were assigned to five groups: Vehicle-treated normal control; vehicle-treated diabetic control; diabetic rats treated with either glibenclamide (0.6 mg/kg) or methanolic stem extract of AM (200 mg/kg), and singly or in combination. Fasting blood glucose (FBG) and oral glucose tolerance test (OGTT) were performed at days 14 and 28 of treatment, while lipid profile and the contents of hepatic and skeletal muscle glycogen were determined at the end of the study (day 29).

Results: When combined, the AM extract significantly reduced (P < 0.05) the effect of glibenclamide in lowering the total area under the OGTT curve as well as the FBG level and in increasing the contents of hepatic and skeletal muscle glycogen as well as the blood level of high-density lipoprotein cholesterol. The two treatments also significantly reduced each others effect in lowering triglycerides, low-density lipoprotein, and total cholesterol.

Conclusion: The methanolic stem extract of AM (200 mg/kg) combined with glibenclamide (0.6 mg/kg) reduced each others beneficial effects on glucose homeostasis and lipid profile in streptozotocin/nicotinamide-induced diabetic rats.

Key words: Anisopus mannii; Glibenclamide; Streptozotocin; Rats; Combination

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Pubmed Style

Chika A, Yahaya A. Effect of coadministration of glibenclamide and methanolic stem extract of Anisopus mannii N.E.Br. (Apocynaceae) on glucose homeostasis and lipid profile in streptozotocin/nicotinamide-induced diabetic rats. Natl J Physiol Pharm Pharmacol. 2019; 9(10): 1045-1051. doi:10.5455/njppp.2019.9.0829205092019

Web Style

Chika A, Yahaya A. Effect of coadministration of glibenclamide and methanolic stem extract of Anisopus mannii N.E.Br. (Apocynaceae) on glucose homeostasis and lipid profile in streptozotocin/nicotinamide-induced diabetic rats. https://www.njppp.com/?mno=61357 [Access: November 01, 2024]. doi:10.5455/njppp.2019.9.0829205092019

AMA (American Medical Association) Style

Chika A, Yahaya A. Effect of coadministration of glibenclamide and methanolic stem extract of Anisopus mannii N.E.Br. (Apocynaceae) on glucose homeostasis and lipid profile in streptozotocin/nicotinamide-induced diabetic rats. Natl J Physiol Pharm Pharmacol. 2019; 9(10): 1045-1051. doi:10.5455/njppp.2019.9.0829205092019

Vancouver/ICMJE Style

Chika A, Yahaya A. Effect of coadministration of glibenclamide and methanolic stem extract of Anisopus mannii N.E.Br. (Apocynaceae) on glucose homeostasis and lipid profile in streptozotocin/nicotinamide-induced diabetic rats. Natl J Physiol Pharm Pharmacol. (2019), [cited November 01, 2024]; 9(10): 1045-1051. doi:10.5455/njppp.2019.9.0829205092019

Harvard Style

Chika, A. & Yahaya, . A. (2019) Effect of coadministration of glibenclamide and methanolic stem extract of Anisopus mannii N.E.Br. (Apocynaceae) on glucose homeostasis and lipid profile in streptozotocin/nicotinamide-induced diabetic rats. Natl J Physiol Pharm Pharmacol, 9 (10), 1045-1051. doi:10.5455/njppp.2019.9.0829205092019

Turabian Style

Chika, Aminu, and Amina Yahaya. 2019. Effect of coadministration of glibenclamide and methanolic stem extract of Anisopus mannii N.E.Br. (Apocynaceae) on glucose homeostasis and lipid profile in streptozotocin/nicotinamide-induced diabetic rats. National Journal of Physiology, Pharmacy and Pharmacology, 9 (10), 1045-1051. doi:10.5455/njppp.2019.9.0829205092019

Chicago Style

Chika, Aminu, and Amina Yahaya. "Effect of coadministration of glibenclamide and methanolic stem extract of Anisopus mannii N.E.Br. (Apocynaceae) on glucose homeostasis and lipid profile in streptozotocin/nicotinamide-induced diabetic rats." National Journal of Physiology, Pharmacy and Pharmacology 9 (2019), 1045-1051. doi:10.5455/njppp.2019.9.0829205092019

MLA (The Modern Language Association) Style

Chika, Aminu, and Amina Yahaya. "Effect of coadministration of glibenclamide and methanolic stem extract of Anisopus mannii N.E.Br. (Apocynaceae) on glucose homeostasis and lipid profile in streptozotocin/nicotinamide-induced diabetic rats." National Journal of Physiology, Pharmacy and Pharmacology 9.10 (2019), 1045-1051. Print. doi:10.5455/njppp.2019.9.0829205092019

APA (American Psychological Association) Style

Chika, A. & Yahaya, . A. (2019) Effect of coadministration of glibenclamide and methanolic stem extract of Anisopus mannii N.E.Br. (Apocynaceae) on glucose homeostasis and lipid profile in streptozotocin/nicotinamide-induced diabetic rats. National Journal of Physiology, Pharmacy and Pharmacology, 9 (10), 1045-1051. doi:10.5455/njppp.2019.9.0829205092019

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