E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Study of heart rate variability to assess autonomic dysfunction in patients with chronic obstructive pulmonary disease of a tertiary care hospital of West Bengal: A cross-sectional comparative study

Maumita Das, Krishnachura Mitra, Tanmoy Banerjee.

Abstract
Background: Chronic obstructive pulmonary disease (COPD) is one of the major causes of morbidity and mortality throughout the world. COPD and its complications also lead to a large number of deaths every year in our country. Cardiac arrhythmias and sudden cardiac death are the major complications of COPD leading to death and disability. Such cardiac complications are often a result of autonomic dysfunction.

Aims and Objectives: This study aims to find out the autonomic dysfunction in moderate COPD patients by comparing their heart rate variability (HRV) parameters with age and sex matched healthy controls.

Materials and Methods: After obtaining approval from the Institutional Ethics Committee, 48 patients of moderate COPD and 54 healthy subjects were assessed and compared with respect to their HRV parameters which included Mean RR, Mean HR, SDNN, NN50, pNN50, root mean square of successive differences (RMSSD), high frequency (HF), low frequency (LF), LF/HF ratio, and SD2/SD1 ratio.

Results: It was found that in comparison to healthy controls, patients of moderate COPD had significant alteration in the following HRV parameters – Mean HR (P: 0.001), RMSSD (P: 0.002), SDNN (P: 0.015), NN50 (P: 0.001), pNN50 (P: 0.000), HF (NU/normalized unit) [P: 0.033], HF (%) [P: 0.002], LF (NU/normalized unit) [P: 0.033], LF (%) [P: 0.012], and LF/HF (P: 0.033).

Conclusion: As there is a significant alteration of several HRV parameters in moderate COPD patients, we conclude that HRV measurement may subserve as a simple and non-invasive tool to assess autonomic dysfunction in patients of COPD at the earliest.

Key words: Moderate Chronic Obstructive Pulmonary Disease; Autonomic Dysfunction; Heart Rate Variability; Time Domain; Frequency Domain


 
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How to Cite this Article
Pubmed Style

Das M, Mitra K, Banerjee T. Study of heart rate variability to assess autonomic dysfunction in patients with chronic obstructive pulmonary disease of a tertiary care hospital of West Bengal: A cross-sectional comparative study. Natl J Physiol Pharm Pharmacol. 2023; 13(3): 485-489. doi:10.5455/njppp.10.5455/njppp.2023.13.07342202218072022


Web Style

Das M, Mitra K, Banerjee T. Study of heart rate variability to assess autonomic dysfunction in patients with chronic obstructive pulmonary disease of a tertiary care hospital of West Bengal: A cross-sectional comparative study. https://www.njppp.com/?mno=60817 [Access: March 01, 2023]. doi:10.5455/njppp.10.5455/njppp.2023.13.07342202218072022


AMA (American Medical Association) Style

Das M, Mitra K, Banerjee T. Study of heart rate variability to assess autonomic dysfunction in patients with chronic obstructive pulmonary disease of a tertiary care hospital of West Bengal: A cross-sectional comparative study. Natl J Physiol Pharm Pharmacol. 2023; 13(3): 485-489. doi:10.5455/njppp.10.5455/njppp.2023.13.07342202218072022



Vancouver/ICMJE Style

Das M, Mitra K, Banerjee T. Study of heart rate variability to assess autonomic dysfunction in patients with chronic obstructive pulmonary disease of a tertiary care hospital of West Bengal: A cross-sectional comparative study. Natl J Physiol Pharm Pharmacol. (2023), [cited March 01, 2023]; 13(3): 485-489. doi:10.5455/njppp.10.5455/njppp.2023.13.07342202218072022



Harvard Style

Das, M., Mitra, . K. & Banerjee, . T. (2023) Study of heart rate variability to assess autonomic dysfunction in patients with chronic obstructive pulmonary disease of a tertiary care hospital of West Bengal: A cross-sectional comparative study. Natl J Physiol Pharm Pharmacol, 13 (3), 485-489. doi:10.5455/njppp.10.5455/njppp.2023.13.07342202218072022



Turabian Style

Das, Maumita, Krishnachura Mitra, and Tanmoy Banerjee. 2023. Study of heart rate variability to assess autonomic dysfunction in patients with chronic obstructive pulmonary disease of a tertiary care hospital of West Bengal: A cross-sectional comparative study. National Journal of Physiology, Pharmacy and Pharmacology, 13 (3), 485-489. doi:10.5455/njppp.10.5455/njppp.2023.13.07342202218072022



Chicago Style

Das, Maumita, Krishnachura Mitra, and Tanmoy Banerjee. "Study of heart rate variability to assess autonomic dysfunction in patients with chronic obstructive pulmonary disease of a tertiary care hospital of West Bengal: A cross-sectional comparative study." National Journal of Physiology, Pharmacy and Pharmacology 13 (2023), 485-489. doi:10.5455/njppp.10.5455/njppp.2023.13.07342202218072022



MLA (The Modern Language Association) Style

Das, Maumita, Krishnachura Mitra, and Tanmoy Banerjee. "Study of heart rate variability to assess autonomic dysfunction in patients with chronic obstructive pulmonary disease of a tertiary care hospital of West Bengal: A cross-sectional comparative study." National Journal of Physiology, Pharmacy and Pharmacology 13.3 (2023), 485-489. Print. doi:10.5455/njppp.10.5455/njppp.2023.13.07342202218072022



APA (American Psychological Association) Style

Das, M., Mitra, . K. & Banerjee, . T. (2023) Study of heart rate variability to assess autonomic dysfunction in patients with chronic obstructive pulmonary disease of a tertiary care hospital of West Bengal: A cross-sectional comparative study. National Journal of Physiology, Pharmacy and Pharmacology, 13 (3), 485-489. doi:10.5455/njppp.10.5455/njppp.2023.13.07342202218072022