E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Megaloblastic anemia in children from Eastern Odisha, India: A clinical and hematological profile analysis

Reshmi Mishra, Mahendra Varma Madduri, Sarbeswar Pradhan.

Abstract
Background: Anemia can have severe implications on the health of children including motor development, behavioral and cognitive development. Furthermore, morbidity from infectious disease is higher in anemic children. Nutritional anemia is a major concern in rural India.

Aim and Objective: We aimed to observe the percentage of megaloblastic anemia among the anemic children and their clinical and hematological parameters.

Materials and Methods: After obtaining permission from the Institutional Ethics Committee, this cross-sectional study was conducted from September 2018 to August 2021. The setting was a tertiary care hospital in the eastern part of Odisha, India. Children of 1–14 years of age presenting with anemia were included in the study. Details clinical examination and blood tests namely mean corpuscular volume, red blood cell count, total leucocyte count, and platelet count were carried out from venous blood. Descriptive statistical analyses were conducted in STATA software version 15.1.

Results: Among the total 150 anemic patients, the majority (126 [84%]) were in the 11–14 years of age group followed by 24 (16%) in 6–10 years of age (P < 0.0001). Girls were more (94 [62.7%]) than boys (56 [37.3%]), P < 0.0001. Anorexia was the most frequently encountered clinical symptom (99.3%) followed by pallor (94%), weakness (86%), fatigue (62%), and hyperpigmentation (37.4%). According to hemoglobin level, 40% were suffering from severe anemia, 38.7% was having moderate, and 21.3% was having mild anemia. The majority (74%) were having both Vitamin B12 and folic acid deficiency followed by 16.7% Vitamin B12, and 9.3% folic acid deficiency.

Conclusion: Girls were presenting with megaloblastic anemia more than boys. Majority of them were suffering from both Vitamin B12 and folic acid deficiency. Children suffering from megaloblastic anemia present with anorexia, pallor, weakness, and fatigue. A proper health promotion program may be designed to aware the parents about the prevention of nutritional anemia.

Key words: Folic Acid Deficiency; Anorexia; Pallor; Anemia; Vitamin B12; Hemoglobins


 
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How to Cite this Article
Pubmed Style

Mishra R, Madduri MV, Pradhan S. Megaloblastic anemia in children from Eastern Odisha, India: A clinical and hematological profile analysis. Natl J Physiol Pharm Pharmacol. 2022; 12(9): 1493-1496. doi:10.5455/njppp.2022.12.01034202220012022


Web Style

Mishra R, Madduri MV, Pradhan S. Megaloblastic anemia in children from Eastern Odisha, India: A clinical and hematological profile analysis. https://www.njppp.com/?mno=5931 [Access: November 24, 2022]. doi:10.5455/njppp.2022.12.01034202220012022


AMA (American Medical Association) Style

Mishra R, Madduri MV, Pradhan S. Megaloblastic anemia in children from Eastern Odisha, India: A clinical and hematological profile analysis. Natl J Physiol Pharm Pharmacol. 2022; 12(9): 1493-1496. doi:10.5455/njppp.2022.12.01034202220012022



Vancouver/ICMJE Style

Mishra R, Madduri MV, Pradhan S. Megaloblastic anemia in children from Eastern Odisha, India: A clinical and hematological profile analysis. Natl J Physiol Pharm Pharmacol. (2022), [cited November 24, 2022]; 12(9): 1493-1496. doi:10.5455/njppp.2022.12.01034202220012022



Harvard Style

Mishra, R., Madduri, . M. V. & Pradhan, . S. (2022) Megaloblastic anemia in children from Eastern Odisha, India: A clinical and hematological profile analysis. Natl J Physiol Pharm Pharmacol, 12 (9), 1493-1496. doi:10.5455/njppp.2022.12.01034202220012022



Turabian Style

Mishra, Reshmi, Mahendra Varma Madduri, and Sarbeswar Pradhan. 2022. Megaloblastic anemia in children from Eastern Odisha, India: A clinical and hematological profile analysis. National Journal of Physiology, Pharmacy and Pharmacology, 12 (9), 1493-1496. doi:10.5455/njppp.2022.12.01034202220012022



Chicago Style

Mishra, Reshmi, Mahendra Varma Madduri, and Sarbeswar Pradhan. "Megaloblastic anemia in children from Eastern Odisha, India: A clinical and hematological profile analysis." National Journal of Physiology, Pharmacy and Pharmacology 12 (2022), 1493-1496. doi:10.5455/njppp.2022.12.01034202220012022



MLA (The Modern Language Association) Style

Mishra, Reshmi, Mahendra Varma Madduri, and Sarbeswar Pradhan. "Megaloblastic anemia in children from Eastern Odisha, India: A clinical and hematological profile analysis." National Journal of Physiology, Pharmacy and Pharmacology 12.9 (2022), 1493-1496. Print. doi:10.5455/njppp.2022.12.01034202220012022



APA (American Psychological Association) Style

Mishra, R., Madduri, . M. V. & Pradhan, . S. (2022) Megaloblastic anemia in children from Eastern Odisha, India: A clinical and hematological profile analysis. National Journal of Physiology, Pharmacy and Pharmacology, 12 (9), 1493-1496. doi:10.5455/njppp.2022.12.01034202220012022