Effect of Ocimum sanctum leaf extract in animal models of anxiety

Ashok Kumar Panigrahi; Saswat Satapathy; Sailen Kumar Mishra; Sunil Kumar Jena

doi:10.5455/njppp.2022.12.062671202209062022

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Online Publishing Date:
20 / 06 / 2022

Natl J Physiol Pharm Pharmacol. 2022; 12(7): 1084-1088

doi: 10.5455/njppp.2022.12.062671202209062022

Effect of Ocimum sanctum leaf extract in animal models of anxiety

Ashok Kumar Panigrahi, Saswat Satapathy, Sailen Kumar Mishra, Sunil Kumar Jena.

Abstract
Background: Anxiety is one of the most prominent psychiatry disorders related to common stress. Approximately two-thirds of anxious patients respond to currently available treatments but the magnitude of problem is still disappointing. Ocimum sanctum (OS), a perennial shrub grown in India, has anti-stress activity. Yet, there is a paucity of data regarding this.

Aims and Objectives: This study aims to evaluate the anti-anxiolytic effect of OS leaf extract (OSLE) in Swiss albino mice.

Materials and Methods: Elevated plus maze (EPM) and open field test are standardized tests done for screening anxiolytic effects of drugs. The animals were grouped and the tests were conducted and the results were compared with the standard drug diazepam.

Results: There was significant increase in the time spent in open arm and number of open arm entries in the diazepam group and group receiving OSLE at dose of 100 mg/kg and 200 mg/kg in EPM test. Furthermore, in the open field test, there was significant increase in the number of square crossed and rearing in the diazepam group and OSLE at dose of 100 mg/kg and 200 mg/kg.

Conclusion: OSLE shows significant anxiolytic effect in EPM and open field test models in Swiss albino mice. This can be further studied to open up new possibilities for new drug development for anxiety.

Key words: Diazepam; Open Field Test; Elevated Plus Maze

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How to Cite this Article

Pubmed Style

Panigrahi AK, Satapathy S, Mishra SK, Jena SK. Effect of Ocimum sanctum leaf extract in animal models of anxiety. Natl J Physiol Pharm Pharmacol. 2022; 12(7): 1084-1088. doi:10.5455/njppp.2022.12.062671202209062022

Web Style

Panigrahi AK, Satapathy S, Mishra SK, Jena SK. Effect of Ocimum sanctum leaf extract in animal models of anxiety. https://www.njppp.com/?mno=55294 [Access: March 15, 2024]. doi:10.5455/njppp.2022.12.062671202209062022

AMA (American Medical Association) Style

Panigrahi AK, Satapathy S, Mishra SK, Jena SK. Effect of Ocimum sanctum leaf extract in animal models of anxiety. Natl J Physiol Pharm Pharmacol. 2022; 12(7): 1084-1088. doi:10.5455/njppp.2022.12.062671202209062022

Vancouver/ICMJE Style

Panigrahi AK, Satapathy S, Mishra SK, Jena SK. Effect of Ocimum sanctum leaf extract in animal models of anxiety. Natl J Physiol Pharm Pharmacol. (2022), [cited March 15, 2024]; 12(7): 1084-1088. doi:10.5455/njppp.2022.12.062671202209062022

Harvard Style

Panigrahi, A. K., Satapathy, . S., Mishra, . S. K. & Jena, . S. K. (2022) Effect of Ocimum sanctum leaf extract in animal models of anxiety. Natl J Physiol Pharm Pharmacol, 12 (7), 1084-1088. doi:10.5455/njppp.2022.12.062671202209062022

Turabian Style

Panigrahi, Ashok Kumar, Saswat Satapathy, Sailen Kumar Mishra, and Sunil Kumar Jena. 2022. Effect of Ocimum sanctum leaf extract in animal models of anxiety. National Journal of Physiology, Pharmacy and Pharmacology, 12 (7), 1084-1088. doi:10.5455/njppp.2022.12.062671202209062022

Chicago Style

Panigrahi, Ashok Kumar, Saswat Satapathy, Sailen Kumar Mishra, and Sunil Kumar Jena. "Effect of Ocimum sanctum leaf extract in animal models of anxiety." National Journal of Physiology, Pharmacy and Pharmacology 12 (2022), 1084-1088. doi:10.5455/njppp.2022.12.062671202209062022

MLA (The Modern Language Association) Style

Panigrahi, Ashok Kumar, Saswat Satapathy, Sailen Kumar Mishra, and Sunil Kumar Jena. "Effect of Ocimum sanctum leaf extract in animal models of anxiety." National Journal of Physiology, Pharmacy and Pharmacology 12.7 (2022), 1084-1088. Print. doi:10.5455/njppp.2022.12.062671202209062022

APA (American Psychological Association) Style

Panigrahi, A. K., Satapathy, . S., Mishra, . S. K. & Jena, . S. K. (2022) Effect of Ocimum sanctum leaf extract in animal models of anxiety. National Journal of Physiology, Pharmacy and Pharmacology, 12 (7), 1084-1088. doi:10.5455/njppp.2022.12.062671202209062022

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