Polypharmacy and potential drug-drug interactions in adult outpatients receiving cardiovascular drugs

Onkar Kiran Manjul; Shraddha Milind Pore; Nimish Ravindra Halasawadekar; Atmik Singh; Nitin Natthuji Puram; Shreyas Ramchandra Burute

doi:10.5455/njppp.2023.13.062631202210062022

2023, Vol: 13, Issue: 3

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Natl J Physiol Pharm Pharmacol. 2023; 13(2): 239-244

doi: 10.5455/njppp.2023.13.062631202210062022

Polypharmacy and potential drug-drug interactions in adult outpatients receiving cardiovascular drugs

Onkar Kiran Manjul, Shraddha Milind Pore, Nimish Ravindra Halasawadekar, Atmik Singh, Nitin Natthuji Puram, Shreyas Ramchandra Burute.

Abstract
Background: The prevalence of polypharmacy is rising and is particularly relevant to cardiovascular diseases. Assessing the extent of polypharmacy and potential drug-drug interactions (pDDIs) is an essential first step in improving safe and rational use of drugs.

Aims and Objective: This study aims to study the frequency of polypharmacy and pDDI in adult outpatients receiving cardiovascular drugs.

Materials and Methods: Prescriptions of all adult outpatients receiving at least one cardiovascular drug were considered for the study. A total of 2027 prescriptions were analyzed for estimating rate of polypharmacy. Out of these, 335 randomly selected prescriptions were analyzed with the help of an online drug interaction checker software for estimating rate of pDDIs, commonly involved drug pairs and severity of pDDI.

Results: The rate of polypharmacy in cardiac outpatients was 56.93% and that of pDDI was 78.81%. The commonly involved drugs in interactions were amlodipine, atenolol, calcium carbonate, atorvastatin, metformin, furosemide, and aspirin. One-third of pDDIs were categorized to be of minor severity while half of the pDDIs belonged to monitor closely category.

Conclusion: Polypharmacy and pDDI are common in cardiac outpatients.

Key words: Polypharmacy; Cardiovascular drugs; Drug interactions

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How to Cite this Article

Pubmed Style

Manjul OK, Pore SM, Halasawadekar NR, Singh A, Puram NN, Burute SR. Polypharmacy and potential drug-drug interactions in adult outpatients receiving cardiovascular drugs. Natl J Physiol Pharm Pharmacol. 2023; 13(2): 239-244. doi:10.5455/njppp.2023.13.062631202210062022

Web Style

Manjul OK, Pore SM, Halasawadekar NR, Singh A, Puram NN, Burute SR. Polypharmacy and potential drug-drug interactions in adult outpatients receiving cardiovascular drugs. https://www.njppp.com/?mno=54238 [Access: March 02, 2023]. doi:10.5455/njppp.2023.13.062631202210062022

AMA (American Medical Association) Style

Manjul OK, Pore SM, Halasawadekar NR, Singh A, Puram NN, Burute SR. Polypharmacy and potential drug-drug interactions in adult outpatients receiving cardiovascular drugs. Natl J Physiol Pharm Pharmacol. 2023; 13(2): 239-244. doi:10.5455/njppp.2023.13.062631202210062022

Vancouver/ICMJE Style

Manjul OK, Pore SM, Halasawadekar NR, Singh A, Puram NN, Burute SR. Polypharmacy and potential drug-drug interactions in adult outpatients receiving cardiovascular drugs. Natl J Physiol Pharm Pharmacol. (2023), [cited March 02, 2023]; 13(2): 239-244. doi:10.5455/njppp.2023.13.062631202210062022

Harvard Style

Manjul, O. K., Pore, . S. M., Halasawadekar, . N. R., Singh, . A., Puram, . N. N. & Burute, . S. R. (2023) Polypharmacy and potential drug-drug interactions in adult outpatients receiving cardiovascular drugs. Natl J Physiol Pharm Pharmacol, 13 (2), 239-244. doi:10.5455/njppp.2023.13.062631202210062022

Turabian Style

Manjul, Onkar Kiran, Shraddha Milind Pore, Nimish Ravindra Halasawadekar, Atmik Singh, Nitin Natthuji Puram, and Shreyas Ramchandra Burute. 2023. Polypharmacy and potential drug-drug interactions in adult outpatients receiving cardiovascular drugs. National Journal of Physiology, Pharmacy and Pharmacology, 13 (2), 239-244. doi:10.5455/njppp.2023.13.062631202210062022

Chicago Style

Manjul, Onkar Kiran, Shraddha Milind Pore, Nimish Ravindra Halasawadekar, Atmik Singh, Nitin Natthuji Puram, and Shreyas Ramchandra Burute. "Polypharmacy and potential drug-drug interactions in adult outpatients receiving cardiovascular drugs." National Journal of Physiology, Pharmacy and Pharmacology 13 (2023), 239-244. doi:10.5455/njppp.2023.13.062631202210062022

MLA (The Modern Language Association) Style

Manjul, Onkar Kiran, Shraddha Milind Pore, Nimish Ravindra Halasawadekar, Atmik Singh, Nitin Natthuji Puram, and Shreyas Ramchandra Burute. "Polypharmacy and potential drug-drug interactions in adult outpatients receiving cardiovascular drugs." National Journal of Physiology, Pharmacy and Pharmacology 13.2 (2023), 239-244. Print. doi:10.5455/njppp.2023.13.062631202210062022

APA (American Psychological Association) Style

Manjul, O. K., Pore, . S. M., Halasawadekar, . N. R., Singh, . A., Puram, . N. N. & Burute, . S. R. (2023) Polypharmacy and potential drug-drug interactions in adult outpatients receiving cardiovascular drugs. National Journal of Physiology, Pharmacy and Pharmacology, 13 (2), 239-244. doi:10.5455/njppp.2023.13.062631202210062022

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